Annexin A1 as a Regulator of Immune Response in Cancer
Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has been extensively studied for its anti-inflammatory activity, it has been shown that, in the cancer context, its activi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/9/2245 |
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| author | Thaise Gonçalves Araújo Sara Teixeira Soares Mota Helen Soares Valença Ferreira Matheus Alves Ribeiro Luiz Ricardo Goulart Lara Vecchi |
| author_facet | Thaise Gonçalves Araújo Sara Teixeira Soares Mota Helen Soares Valença Ferreira Matheus Alves Ribeiro Luiz Ricardo Goulart Lara Vecchi |
| author_sort | Thaise Gonçalves Araújo |
| collection | DOAJ |
| description | Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has been extensively studied for its anti-inflammatory activity, it has been shown that, in the cancer context, its activity switches from anti-inflammatory to pro-inflammatory. Remarkably, Annexin A1 shows pro-invasive and pro-tumoral properties in several cancers either by eliciting autocrine signaling in cancer cells or by inducing a favorable tumor microenvironment. Indeed, the signaling of the <i>N</i>-terminal peptide of AnxA1 has been described to promote the switching of macrophages to the pro-tumoral M2 phenotype. Moreover, AnxA1 has been described to prevent the induction of antigen-specific cytotoxic T cell response and to play an essential role in the induction of regulatory T lymphocytes. In this way, Annexin A1 inhibits the anti-tumor immunity and supports the formation of an immunosuppressed tumor microenvironment that promotes tumor growth and metastasis. For these reasons, in this review we aim to describe the role of Annexin A1 in the establishment of the tumor microenvironment, focusing on the immunosuppressive and immunomodulatory activities of Annexin A1 and on its interaction with the epidermal growth factor receptor. |
| first_indexed | 2024-03-10T07:49:27Z |
| format | Article |
| id | doaj.art-86301f41f936439581010cbbb51f2cc4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:49:27Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-86301f41f936439581010cbbb51f2cc42023-11-22T12:23:06ZengMDPI AGCells2073-44092021-08-01109224510.3390/cells10092245Annexin A1 as a Regulator of Immune Response in CancerThaise Gonçalves Araújo0Sara Teixeira Soares Mota1Helen Soares Valença Ferreira2Matheus Alves Ribeiro3Luiz Ricardo Goulart4Lara Vecchi5Laboratory of Genetics and Biotechnology, Federal University of Uberlandia, Patos de Minas 387400-128, MG, BrazilLaboratory of Genetics and Biotechnology, Federal University of Uberlandia, Patos de Minas 387400-128, MG, BrazilLaboratory of Genetics and Biotechnology, Federal University of Uberlandia, Patos de Minas 387400-128, MG, BrazilLaboratory of Genetics and Biotechnology, Federal University of Uberlandia, Patos de Minas 387400-128, MG, BrazilLaboratory of Nanobiotechnology, Federal University of Uberlandia, Uberlandia 38400-902, MG, BrazilLaboratory of Nanobiotechnology, Federal University of Uberlandia, Uberlandia 38400-902, MG, BrazilAnnexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has been extensively studied for its anti-inflammatory activity, it has been shown that, in the cancer context, its activity switches from anti-inflammatory to pro-inflammatory. Remarkably, Annexin A1 shows pro-invasive and pro-tumoral properties in several cancers either by eliciting autocrine signaling in cancer cells or by inducing a favorable tumor microenvironment. Indeed, the signaling of the <i>N</i>-terminal peptide of AnxA1 has been described to promote the switching of macrophages to the pro-tumoral M2 phenotype. Moreover, AnxA1 has been described to prevent the induction of antigen-specific cytotoxic T cell response and to play an essential role in the induction of regulatory T lymphocytes. In this way, Annexin A1 inhibits the anti-tumor immunity and supports the formation of an immunosuppressed tumor microenvironment that promotes tumor growth and metastasis. For these reasons, in this review we aim to describe the role of Annexin A1 in the establishment of the tumor microenvironment, focusing on the immunosuppressive and immunomodulatory activities of Annexin A1 and on its interaction with the epidermal growth factor receptor.https://www.mdpi.com/2073-4409/10/9/2245Annexin A1tumor microenvironmentimmune-suppressioncancer aggressiveness |
| spellingShingle | Thaise Gonçalves Araújo Sara Teixeira Soares Mota Helen Soares Valença Ferreira Matheus Alves Ribeiro Luiz Ricardo Goulart Lara Vecchi Annexin A1 as a Regulator of Immune Response in Cancer Cells Annexin A1 tumor microenvironment immune-suppression cancer aggressiveness |
| title | Annexin A1 as a Regulator of Immune Response in Cancer |
| title_full | Annexin A1 as a Regulator of Immune Response in Cancer |
| title_fullStr | Annexin A1 as a Regulator of Immune Response in Cancer |
| title_full_unstemmed | Annexin A1 as a Regulator of Immune Response in Cancer |
| title_short | Annexin A1 as a Regulator of Immune Response in Cancer |
| title_sort | annexin a1 as a regulator of immune response in cancer |
| topic | Annexin A1 tumor microenvironment immune-suppression cancer aggressiveness |
| url | https://www.mdpi.com/2073-4409/10/9/2245 |
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