Acupuncture for response and complete pain relief time of acute renal colic: Secondary analysis of a randomized controlled trial
Background: The integration of acupuncture with intramuscular injection of diclofenac sodium can expedite the onset of analgesia in treating acute renal colic caused by urolithiasis. However, it remains unclear whether acupuncture can accelerate pain relief constantly until complete remission. This...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422024000015 |
| _version_ | 1827294124613566464 |
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| author | Xue-Zhou Wang Cun-Zhi Liu Li-Qiong Wang Zhi-Cheng Qu Ying Cao Shi-Yan Yan Jing-Wen Yang Jian-Feng Tu |
| author_facet | Xue-Zhou Wang Cun-Zhi Liu Li-Qiong Wang Zhi-Cheng Qu Ying Cao Shi-Yan Yan Jing-Wen Yang Jian-Feng Tu |
| author_sort | Xue-Zhou Wang |
| collection | DOAJ |
| description | Background: The integration of acupuncture with intramuscular injection of diclofenac sodium can expedite the onset of analgesia in treating acute renal colic caused by urolithiasis. However, it remains unclear whether acupuncture can accelerate pain relief constantly until complete remission. This study aimed to explore the extent to which acupuncture can expedite the onset time of response or complete pain relief in treating acute renal colic, and the predictive value of patient characteristics for treatment efficacy. Methods: This secondary analysis utilized data from a prior randomized controlled trial. Eighty patients with acute renal colic were randomly assigned 1:1 to the acupuncture group or the sham acupuncture group. After intramuscular injection of diclofenac sodium, acupuncture or sham acupuncture was delivered to patients. The outcomes included time to response (at least a 50 % reduction in pain) and complete pain relief. Between-group comparison under the 2 events was estimated by Kaplan-Meier methodology. Subgroup analysis was performed utilizing the Cox proportional hazards model. Results: The median response time and complete pain relief time in the acupuncture group were lower than those in the sham acupuncture group (5 vs 30 min, Log Rank P < 0.001; 20 min vs not observed, Log Rank P < 0.001, respectively). Hazard Ratios (HRs) for response across all subgroups favored the acupuncture group. All HRs for complete pain relief favored acupuncture, expect large stone and moderate pain at baseline. No interaction was found in either event. Conclusion: Acupuncture can accelerate the response time and complete pain relief time for patients with acute renal colic, with the efficacy universally. Trial registration: This study has been registered at Chinese Clinical Trial Registry: ChiCTR1900025202. |
| first_indexed | 2024-03-08T00:49:10Z |
| format | Article |
| id | doaj.art-86306f8aca7a4bc882b3488a608b5d57 |
| institution | Directory Open Access Journal |
| issn | 2213-4220 |
| language | English |
| last_indexed | 2024-04-24T13:50:32Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj.art-86306f8aca7a4bc882b3488a608b5d572024-04-04T05:04:09ZengElsevierIntegrative Medicine Research2213-42202024-03-01131101021Acupuncture for response and complete pain relief time of acute renal colic: Secondary analysis of a randomized controlled trialXue-Zhou Wang0Cun-Zhi Liu1Li-Qiong Wang2Zhi-Cheng Qu3Ying Cao4Shi-Yan Yan5Jing-Wen Yang6Jian-Feng Tu7International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China; Corresponding authors at: International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.Emergency Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaEmergency Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaInternational Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China; Corresponding authors at: International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.Background: The integration of acupuncture with intramuscular injection of diclofenac sodium can expedite the onset of analgesia in treating acute renal colic caused by urolithiasis. However, it remains unclear whether acupuncture can accelerate pain relief constantly until complete remission. This study aimed to explore the extent to which acupuncture can expedite the onset time of response or complete pain relief in treating acute renal colic, and the predictive value of patient characteristics for treatment efficacy. Methods: This secondary analysis utilized data from a prior randomized controlled trial. Eighty patients with acute renal colic were randomly assigned 1:1 to the acupuncture group or the sham acupuncture group. After intramuscular injection of diclofenac sodium, acupuncture or sham acupuncture was delivered to patients. The outcomes included time to response (at least a 50 % reduction in pain) and complete pain relief. Between-group comparison under the 2 events was estimated by Kaplan-Meier methodology. Subgroup analysis was performed utilizing the Cox proportional hazards model. Results: The median response time and complete pain relief time in the acupuncture group were lower than those in the sham acupuncture group (5 vs 30 min, Log Rank P < 0.001; 20 min vs not observed, Log Rank P < 0.001, respectively). Hazard Ratios (HRs) for response across all subgroups favored the acupuncture group. All HRs for complete pain relief favored acupuncture, expect large stone and moderate pain at baseline. No interaction was found in either event. Conclusion: Acupuncture can accelerate the response time and complete pain relief time for patients with acute renal colic, with the efficacy universally. Trial registration: This study has been registered at Chinese Clinical Trial Registry: ChiCTR1900025202.http://www.sciencedirect.com/science/article/pii/S2213422024000015AcupunctureRenal colicEmergency medicineSurvival analysis |
| spellingShingle | Xue-Zhou Wang Cun-Zhi Liu Li-Qiong Wang Zhi-Cheng Qu Ying Cao Shi-Yan Yan Jing-Wen Yang Jian-Feng Tu Acupuncture for response and complete pain relief time of acute renal colic: Secondary analysis of a randomized controlled trial Integrative Medicine Research Acupuncture Renal colic Emergency medicine Survival analysis |
| title | Acupuncture for response and complete pain relief time of acute renal colic: Secondary analysis of a randomized controlled trial |
| title_full | Acupuncture for response and complete pain relief time of acute renal colic: Secondary analysis of a randomized controlled trial |
| title_fullStr | Acupuncture for response and complete pain relief time of acute renal colic: Secondary analysis of a randomized controlled trial |
| title_full_unstemmed | Acupuncture for response and complete pain relief time of acute renal colic: Secondary analysis of a randomized controlled trial |
| title_short | Acupuncture for response and complete pain relief time of acute renal colic: Secondary analysis of a randomized controlled trial |
| title_sort | acupuncture for response and complete pain relief time of acute renal colic secondary analysis of a randomized controlled trial |
| topic | Acupuncture Renal colic Emergency medicine Survival analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2213422024000015 |
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