A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike
To fully understand the potential shortcomings of SARS-CoV-2 vaccination, it is necessary to delineate the properties of the antibodies elicited, during immunization, and also infection. Through investigation of the SARS-CoV-2 spike-reactive B cell repertoire, authors identify following infection, a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32232-0 |
| _version_ | 1817968070175490048 |
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| author | Mathieu Claireaux Tom G. Caniels Marlon de Gast Julianna Han Denise Guerra Gius Kerster Barbera D. C. van Schaik Aldo Jongejan Angela I. Schriek Marloes Grobben Philip J. M. Brouwer Karlijn van der Straten Yoann Aldon Joan Capella-Pujol Jonne L. Snitselaar Wouter Olijhoek Aafke Aartse Mitch Brinkkemper Ilja Bontjer Judith A. Burger Meliawati Poniman Tom P. L. Bijl Jonathan L. Torres Jeffrey Copps Isabel Cuella Martin Steven W. de Taeye Godelieve J. de Bree Andrew B. Ward Kwinten Sliepen Antoine H. C. van Kampen Perry D. Moerland Rogier W. Sanders Marit J. van Gils |
| author_facet | Mathieu Claireaux Tom G. Caniels Marlon de Gast Julianna Han Denise Guerra Gius Kerster Barbera D. C. van Schaik Aldo Jongejan Angela I. Schriek Marloes Grobben Philip J. M. Brouwer Karlijn van der Straten Yoann Aldon Joan Capella-Pujol Jonne L. Snitselaar Wouter Olijhoek Aafke Aartse Mitch Brinkkemper Ilja Bontjer Judith A. Burger Meliawati Poniman Tom P. L. Bijl Jonathan L. Torres Jeffrey Copps Isabel Cuella Martin Steven W. de Taeye Godelieve J. de Bree Andrew B. Ward Kwinten Sliepen Antoine H. C. van Kampen Perry D. Moerland Rogier W. Sanders Marit J. van Gils |
| author_sort | Mathieu Claireaux |
| collection | DOAJ |
| description | To fully understand the potential shortcomings of SARS-CoV-2 vaccination, it is necessary to delineate the properties of the antibodies elicited, during immunization, and also infection. Through investigation of the SARS-CoV-2 spike-reactive B cell repertoire, authors identify following infection, a subset of B cells enriched and almost exclusively target a non-neutralizing S2 epitope present in aberrant forms. |
| first_indexed | 2024-04-13T20:03:08Z |
| format | Article |
| id | doaj.art-86312e11f65b467f911c74e87e292a4a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T20:03:08Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-86312e11f65b467f911c74e87e292a4a2022-12-22T02:32:07ZengNature PortfolioNature Communications2041-17232022-08-0113111510.1038/s41467-022-32232-0A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spikeMathieu Claireaux0Tom G. Caniels1Marlon de Gast2Julianna Han3Denise Guerra4Gius Kerster5Barbera D. C. van Schaik6Aldo Jongejan7Angela I. Schriek8Marloes Grobben9Philip J. M. Brouwer10Karlijn van der Straten11Yoann Aldon12Joan Capella-Pujol13Jonne L. Snitselaar14Wouter Olijhoek15Aafke Aartse16Mitch Brinkkemper17Ilja Bontjer18Judith A. Burger19Meliawati Poniman20Tom P. L. Bijl21Jonathan L. Torres22Jeffrey Copps23Isabel Cuella Martin24Steven W. de Taeye25Godelieve J. de Bree26Andrew B. Ward27Kwinten Sliepen28Antoine H. C. van Kampen29Perry D. Moerland30Rogier W. Sanders31Marit J. van Gils32Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyBioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Public HealthBioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Public HealthAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyDepartment of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Infection and ImmunityDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyBioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Public HealthBioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Public HealthAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental VirologyTo fully understand the potential shortcomings of SARS-CoV-2 vaccination, it is necessary to delineate the properties of the antibodies elicited, during immunization, and also infection. Through investigation of the SARS-CoV-2 spike-reactive B cell repertoire, authors identify following infection, a subset of B cells enriched and almost exclusively target a non-neutralizing S2 epitope present in aberrant forms.https://doi.org/10.1038/s41467-022-32232-0 |
| spellingShingle | Mathieu Claireaux Tom G. Caniels Marlon de Gast Julianna Han Denise Guerra Gius Kerster Barbera D. C. van Schaik Aldo Jongejan Angela I. Schriek Marloes Grobben Philip J. M. Brouwer Karlijn van der Straten Yoann Aldon Joan Capella-Pujol Jonne L. Snitselaar Wouter Olijhoek Aafke Aartse Mitch Brinkkemper Ilja Bontjer Judith A. Burger Meliawati Poniman Tom P. L. Bijl Jonathan L. Torres Jeffrey Copps Isabel Cuella Martin Steven W. de Taeye Godelieve J. de Bree Andrew B. Ward Kwinten Sliepen Antoine H. C. van Kampen Perry D. Moerland Rogier W. Sanders Marit J. van Gils A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike Nature Communications |
| title | A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike |
| title_full | A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike |
| title_fullStr | A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike |
| title_full_unstemmed | A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike |
| title_short | A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike |
| title_sort | public antibody class recognizes an s2 epitope exposed on open conformations of sars cov 2 spike |
| url | https://doi.org/10.1038/s41467-022-32232-0 |
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