Structural Changes of RNA in Complex with Proteins in the SRP
The structural flexibility of RNA allows it to exist in several shapes and sizes. Thus, RNA is functionally diverse and is known to be involved in processes such as catalysis, ligand binding, and most importantly, protein recognition. RNA can adopt different structures, which can often dictate its f...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-02-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fmolb.2018.00007/full |
| _version_ | 1819266927441215488 |
|---|---|
| author | Janine K. Flores Sandro F. Ataide |
| author_facet | Janine K. Flores Sandro F. Ataide |
| author_sort | Janine K. Flores |
| collection | DOAJ |
| description | The structural flexibility of RNA allows it to exist in several shapes and sizes. Thus, RNA is functionally diverse and is known to be involved in processes such as catalysis, ligand binding, and most importantly, protein recognition. RNA can adopt different structures, which can often dictate its functionality. When RNA binds onto protein to form a ribonucleoprotein complex (RNP), multiple interactions and conformational changes occur with the RNA and protein. However, there is the question of whether there is a specific pattern for these changes to occur upon recognition. In particular when RNP complexity increases with the addition of multiple proteins/RNA, it becomes difficult to structurally characterize the overall changes using the current structural determination techniques. Hence, there is a need to use a combination of biochemical, structural and computational modeling to achieve a better understanding of the processes that RNPs are involved. Nevertheless, there are well-characterized systems that are evolutionarily conserved [such as the signal recognition particle (SRP)] that give us important information on the structural changes of RNA and protein upon complex formation. |
| first_indexed | 2024-12-23T21:09:03Z |
| format | Article |
| id | doaj.art-863306de6d5b445fb21b607b8db9d3a7 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-23T21:09:03Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-863306de6d5b445fb21b607b8db9d3a72022-12-21T17:31:07ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2018-02-01510.3389/fmolb.2018.00007330379Structural Changes of RNA in Complex with Proteins in the SRPJanine K. FloresSandro F. AtaideThe structural flexibility of RNA allows it to exist in several shapes and sizes. Thus, RNA is functionally diverse and is known to be involved in processes such as catalysis, ligand binding, and most importantly, protein recognition. RNA can adopt different structures, which can often dictate its functionality. When RNA binds onto protein to form a ribonucleoprotein complex (RNP), multiple interactions and conformational changes occur with the RNA and protein. However, there is the question of whether there is a specific pattern for these changes to occur upon recognition. In particular when RNP complexity increases with the addition of multiple proteins/RNA, it becomes difficult to structurally characterize the overall changes using the current structural determination techniques. Hence, there is a need to use a combination of biochemical, structural and computational modeling to achieve a better understanding of the processes that RNPs are involved. Nevertheless, there are well-characterized systems that are evolutionarily conserved [such as the signal recognition particle (SRP)] that give us important information on the structural changes of RNA and protein upon complex formation.http://journal.frontiersin.org/article/10.3389/fmolb.2018.00007/fullRNA structureprotein conformationRNP complexesRNA interactionRNA structure and function |
| spellingShingle | Janine K. Flores Sandro F. Ataide Structural Changes of RNA in Complex with Proteins in the SRP Frontiers in Molecular Biosciences RNA structure protein conformation RNP complexes RNA interaction RNA structure and function |
| title | Structural Changes of RNA in Complex with Proteins in the SRP |
| title_full | Structural Changes of RNA in Complex with Proteins in the SRP |
| title_fullStr | Structural Changes of RNA in Complex with Proteins in the SRP |
| title_full_unstemmed | Structural Changes of RNA in Complex with Proteins in the SRP |
| title_short | Structural Changes of RNA in Complex with Proteins in the SRP |
| title_sort | structural changes of rna in complex with proteins in the srp |
| topic | RNA structure protein conformation RNP complexes RNA interaction RNA structure and function |
| url | http://journal.frontiersin.org/article/10.3389/fmolb.2018.00007/full |
| work_keys_str_mv | AT janinekflores structuralchangesofrnaincomplexwithproteinsinthesrp AT sandrofataide structuralchangesofrnaincomplexwithproteinsinthesrp |