OXA-48 Carbapenemase in <i>Klebsiella pneumoniae</i> Sequence Type 307 in Ecuador
Antibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. <i>Klebsiella pneumoniae</i> is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections....
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/3/435 |
| _version_ | 1828759673790005248 |
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| author | José E. Villacís Jorge A. Reyes Hugo G. Castelán-Sánchez Sonia Dávila-Ramos Miguel Angel Lazo Ahmad Wali Luis A. Bodero Yadira Toapanta Cristina Naranjo Lorena Montero Josefina Campos Marcelo G. Galas Mónica C. Gestal |
| author_facet | José E. Villacís Jorge A. Reyes Hugo G. Castelán-Sánchez Sonia Dávila-Ramos Miguel Angel Lazo Ahmad Wali Luis A. Bodero Yadira Toapanta Cristina Naranjo Lorena Montero Josefina Campos Marcelo G. Galas Mónica C. Gestal |
| author_sort | José E. Villacís |
| collection | DOAJ |
| description | Antibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. <i>Klebsiella pneumoniae</i> is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections. The ubiquity of this microorganism confounds with the great increase in antibiotic resistance and have bred great concern worldwide. <i>K. pneumoniae</i> sequence type (ST) 307 is a widespread emerging clone associated with hospital-acquired infections, although sporadic community infections have also been reported. The aim of our study is to describe the first case of <i>Klebsiella pneumoniae</i> (ST) 307 harboring the blaOXA-48-like gene in Ecuador. We characterized a new plasmid that carry OXA-48 and could be the source of future outbreaks. The strain was recovered from a patient with cancer previously admitted in a Ukrainian hospital, suggesting that this mechanism of resistance could be imported. These findings highlight the importance of programs based on active molecular surveillance for the intercontinental spread of multidrug-resistant microorganisms with emergent carbapenemases. |
| first_indexed | 2024-12-11T01:01:56Z |
| format | Article |
| id | doaj.art-86364ec375c143a597b72ba7a2ca808b |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-12-11T01:01:56Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-86364ec375c143a597b72ba7a2ca808b2022-12-22T01:26:18ZengMDPI AGMicroorganisms2076-26072020-03-018343510.3390/microorganisms8030435microorganisms8030435OXA-48 Carbapenemase in <i>Klebsiella pneumoniae</i> Sequence Type 307 in EcuadorJosé E. Villacís0Jorge A. Reyes1Hugo G. Castelán-Sánchez2Sonia Dávila-Ramos3Miguel Angel Lazo4Ahmad Wali5Luis A. Bodero6Yadira Toapanta7Cristina Naranjo8Lorena Montero9Josefina Campos10Marcelo G. Galas11Mónica C. Gestal12Facultad de Medicina, Pontificia Universidad Católica del Ecuador, Quito 170143, EcuadorFacultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170129, EcuadorCentro de Investigación en Dinámica Celular, Instituto de Investigaciones Básicas y Aplicadas Universidad Autónoma del Estado de Morelos, Cuernavaca Morelos 62209, MexicoCentro de Investigación en Dinámica Celular, Instituto de Investigaciones Básicas y Aplicadas Universidad Autónoma del Estado de Morelos, Cuernavaca Morelos 62209, MexicoHospital de Especialidades Eugenio Espejo, Quito 170136, EcuadorHospital de Especialidades Eugenio Espejo, Quito 170136, EcuadorMinisterio de Salud Pública, Quito 170702, EcuadorHospital de Especialidades Eugenio Espejo, Quito 170136, EcuadorHospital de Especialidades Eugenio Espejo, Quito 170136, EcuadorMinisterio de Salud Pública, Quito 170702, EcuadorAdministración Nacional de Laboratorios e Institutos de Salud ”Dr. Carlos G. Malbrán,” Buenos Aires 1281, ArgentinaPan American Health Organization/WHO, Washington, DC 20037, USALouisiana State University (LSU), Health Science Center, Shreveport, LA 71103, USAAntibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. <i>Klebsiella pneumoniae</i> is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections. The ubiquity of this microorganism confounds with the great increase in antibiotic resistance and have bred great concern worldwide. <i>K. pneumoniae</i> sequence type (ST) 307 is a widespread emerging clone associated with hospital-acquired infections, although sporadic community infections have also been reported. The aim of our study is to describe the first case of <i>Klebsiella pneumoniae</i> (ST) 307 harboring the blaOXA-48-like gene in Ecuador. We characterized a new plasmid that carry OXA-48 and could be the source of future outbreaks. The strain was recovered from a patient with cancer previously admitted in a Ukrainian hospital, suggesting that this mechanism of resistance could be imported. These findings highlight the importance of programs based on active molecular surveillance for the intercontinental spread of multidrug-resistant microorganisms with emergent carbapenemases.https://www.mdpi.com/2076-2607/8/3/435<i>klebsiella pneumoniae</i>oxa-48 carbapenemasecarbapenemase-producing enterobacterales |
| spellingShingle | José E. Villacís Jorge A. Reyes Hugo G. Castelán-Sánchez Sonia Dávila-Ramos Miguel Angel Lazo Ahmad Wali Luis A. Bodero Yadira Toapanta Cristina Naranjo Lorena Montero Josefina Campos Marcelo G. Galas Mónica C. Gestal OXA-48 Carbapenemase in <i>Klebsiella pneumoniae</i> Sequence Type 307 in Ecuador Microorganisms <i>klebsiella pneumoniae</i> oxa-48 carbapenemase carbapenemase-producing enterobacterales |
| title | OXA-48 Carbapenemase in <i>Klebsiella pneumoniae</i> Sequence Type 307 in Ecuador |
| title_full | OXA-48 Carbapenemase in <i>Klebsiella pneumoniae</i> Sequence Type 307 in Ecuador |
| title_fullStr | OXA-48 Carbapenemase in <i>Klebsiella pneumoniae</i> Sequence Type 307 in Ecuador |
| title_full_unstemmed | OXA-48 Carbapenemase in <i>Klebsiella pneumoniae</i> Sequence Type 307 in Ecuador |
| title_short | OXA-48 Carbapenemase in <i>Klebsiella pneumoniae</i> Sequence Type 307 in Ecuador |
| title_sort | oxa 48 carbapenemase in i klebsiella pneumoniae i sequence type 307 in ecuador |
| topic | <i>klebsiella pneumoniae</i> oxa-48 carbapenemase carbapenemase-producing enterobacterales |
| url | https://www.mdpi.com/2076-2607/8/3/435 |
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