Central hemodynamics in relation to low-level environmental lead exposure
Purpose: Arterial stiffness predicts cardiovascular complications. The association between arterial stiffness and blood lead (BL) remains poorly documented. We aimed to assess the association of central hemodynamic measurements, including pulse wave velocity (aPWV), with blood lead in a Flemish popu...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-05-01
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| Series: | Blood Pressure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08037051.2019.1658518 |
| _version_ | 1797685088512638976 |
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| author | Cai-Guo Yu Fang-Fei Wei Zhen-Yu Zhang Lutgarde Thijs Wen-Yi Yang Blerim Mujaj Ying-Mei Feng José Boggia Harry A. Roels Harry A. J. Struijker-Boudier Tim S. Nawrot Peter Verhamme Jan A. Staessen |
| author_facet | Cai-Guo Yu Fang-Fei Wei Zhen-Yu Zhang Lutgarde Thijs Wen-Yi Yang Blerim Mujaj Ying-Mei Feng José Boggia Harry A. Roels Harry A. J. Struijker-Boudier Tim S. Nawrot Peter Verhamme Jan A. Staessen |
| author_sort | Cai-Guo Yu |
| collection | DOAJ |
| description | Purpose: Arterial stiffness predicts cardiovascular complications. The association between arterial stiffness and blood lead (BL) remains poorly documented. We aimed to assess the association of central hemodynamic measurements, including pulse wave velocity (aPWV), with blood lead in a Flemish population. Materials and Methods: In this Flemish population study (mean age, 37.0 years; 48.3% women), 267 participants had their whole BL and 24-h urinary cadmium (UCd) measured by electrothermal atomic absorption spectrometry in 1985–2005. After 9.4 years (median), they underwent applanation tonometry to estimate central pulse pressure (cPP), the augmentation index (AI), pressure amplification (PA), and aPWV. The amplitudes of the forward (Pf) and backward (Pb) pulse waves and reflection index (RI) were derived by a pressure-based wave separation algorithm. Results: BL averaged 2.93 μg/dL (interquartile range, 1.80–4.70) and UCd 4.79 µg (2.91–7.85). Mean values were 45.0 ± 15.2 mm Hg for cPP, 24.4 ± 12.4% for AI, 1.34 ± 0.21 for PA, 7.65 ± 1.74 m/s for aPWV, 32.7 ± 9.9 mm Hg for Pf, 21.8 ± 8.4 mm Hg for Pb, and 66.9 ± 18.4% for RI. The multivariable-adjusted association sizes for a 2-fold higher BL were: +3.03% (95% confidence interval, 1.56, 4.50) for AI; −0.06 (−0.08, −0.04) for PA; 1.02 mm Hg (0.02, 2.02) for Pb; and 3.98% (1.71, 6.24) for RI (p ≤ .045). In 206 participants never on antihypertensive drug treatment, association sizes were +2.59 mm Hg (0.39, 4.79) for cPP and +0.26 m/s (0.03, 0.50) for aPWV. Analyses adjusted for co-exposure to cadmium were consistent. Conclusion: In conclusion, low-level environmental lead exposure possibly contributes to arterial stiffening and wave reflection from peripheral sites. |
| first_indexed | 2024-03-12T00:39:15Z |
| format | Article |
| id | doaj.art-86367a3ce52b45c39711d44453c71d47 |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:39:15Z |
| publishDate | 2020-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-86367a3ce52b45c39711d44453c71d472023-09-15T08:45:23ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992020-05-0129315716710.1080/08037051.2019.16585181658518Central hemodynamics in relation to low-level environmental lead exposureCai-Guo Yu0Fang-Fei Wei1Zhen-Yu Zhang2Lutgarde Thijs3Wen-Yi Yang4Blerim Mujaj5Ying-Mei Feng6José Boggia7Harry A. Roels8Harry A. J. Struijker-Boudier9Tim S. Nawrot10Peter Verhamme11Jan A. Staessen12University of LeuvenUniversity of LeuvenUniversity of LeuvenUniversity of LeuvenUniversity of LeuvenUniversity of LeuvenCapital Medical UniversityUniversidad de la RepúblicaHasselt UniversityMaastricht UniversityHasselt UniversityUniversity of LeuvenUniversity of LeuvenPurpose: Arterial stiffness predicts cardiovascular complications. The association between arterial stiffness and blood lead (BL) remains poorly documented. We aimed to assess the association of central hemodynamic measurements, including pulse wave velocity (aPWV), with blood lead in a Flemish population. Materials and Methods: In this Flemish population study (mean age, 37.0 years; 48.3% women), 267 participants had their whole BL and 24-h urinary cadmium (UCd) measured by electrothermal atomic absorption spectrometry in 1985–2005. After 9.4 years (median), they underwent applanation tonometry to estimate central pulse pressure (cPP), the augmentation index (AI), pressure amplification (PA), and aPWV. The amplitudes of the forward (Pf) and backward (Pb) pulse waves and reflection index (RI) were derived by a pressure-based wave separation algorithm. Results: BL averaged 2.93 μg/dL (interquartile range, 1.80–4.70) and UCd 4.79 µg (2.91–7.85). Mean values were 45.0 ± 15.2 mm Hg for cPP, 24.4 ± 12.4% for AI, 1.34 ± 0.21 for PA, 7.65 ± 1.74 m/s for aPWV, 32.7 ± 9.9 mm Hg for Pf, 21.8 ± 8.4 mm Hg for Pb, and 66.9 ± 18.4% for RI. The multivariable-adjusted association sizes for a 2-fold higher BL were: +3.03% (95% confidence interval, 1.56, 4.50) for AI; −0.06 (−0.08, −0.04) for PA; 1.02 mm Hg (0.02, 2.02) for Pb; and 3.98% (1.71, 6.24) for RI (p ≤ .045). In 206 participants never on antihypertensive drug treatment, association sizes were +2.59 mm Hg (0.39, 4.79) for cPP and +0.26 m/s (0.03, 0.50) for aPWV. Analyses adjusted for co-exposure to cadmium were consistent. Conclusion: In conclusion, low-level environmental lead exposure possibly contributes to arterial stiffening and wave reflection from peripheral sites.http://dx.doi.org/10.1080/08037051.2019.1658518arterial stiffnesscentral blood pressurecentral hemodynamicsleadenvironmental medicine |
| spellingShingle | Cai-Guo Yu Fang-Fei Wei Zhen-Yu Zhang Lutgarde Thijs Wen-Yi Yang Blerim Mujaj Ying-Mei Feng José Boggia Harry A. Roels Harry A. J. Struijker-Boudier Tim S. Nawrot Peter Verhamme Jan A. Staessen Central hemodynamics in relation to low-level environmental lead exposure Blood Pressure arterial stiffness central blood pressure central hemodynamics lead environmental medicine |
| title | Central hemodynamics in relation to low-level environmental lead exposure |
| title_full | Central hemodynamics in relation to low-level environmental lead exposure |
| title_fullStr | Central hemodynamics in relation to low-level environmental lead exposure |
| title_full_unstemmed | Central hemodynamics in relation to low-level environmental lead exposure |
| title_short | Central hemodynamics in relation to low-level environmental lead exposure |
| title_sort | central hemodynamics in relation to low level environmental lead exposure |
| topic | arterial stiffness central blood pressure central hemodynamics lead environmental medicine |
| url | http://dx.doi.org/10.1080/08037051.2019.1658518 |
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