Randomized Controlled Trial of Durotomy as an Adjunct to Routine Decompressive Surgery for Dogs With Severe Acute Spinal Cord Injury
Although many interventions for acute spinal cord injury (SCI) appear promising in experimental models, translation directly from experimental animals to human patients is a large step that can be problematic. Acute SCI occurs frequently in companion dogs and may provide a model to ease translation....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2024-02-01
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| Series: | Neurotrauma Reports |
| Subjects: | |
| Online Access: | https://www.liebertpub.com/doi/full/10.1089/NEUR.2023.0129 |
| _version_ | 1797301665397735424 |
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| author | Nick D. Jeffery John H. Rossmeisl Tom R. Harcourt-Brown Nicolas Granger Daisuke Ito Kari Foss Damian Chase |
| author_facet | Nick D. Jeffery John H. Rossmeisl Tom R. Harcourt-Brown Nicolas Granger Daisuke Ito Kari Foss Damian Chase |
| author_sort | Nick D. Jeffery |
| collection | DOAJ |
| description | Although many interventions for acute spinal cord injury (SCI) appear promising in experimental models, translation directly from experimental animals to human patients is a large step that can be problematic. Acute SCI occurs frequently in companion dogs and may provide a model to ease translation. Recently, incision of the dura has been highlighted in both research animals and human patients as a means of reducing intraspinal pressure, with a view to improving perfusion of the injured tissue and enhancing functional recovery. Observational clinical data in humans and dogs support the notion that it may also improve functional outcome. Here, we report the results of a multi-center randomized controlled trial of durotomy as an adjunct to traditional decompressive surgery for treatment of severe thoracolumbar SCI caused by acute intervertebral disc herniation in dogs. Sample-size calculation was based on the proportion of dogs recovering ambulation improving from an expected 55% in the traditional surgery group to 70% in the durotomy group. Over a 3.5-year period, we enrolled 140 dogs, of which 128 had appropriate duration of follow-up. Overall, 65 (51%) dogs recovered ambulation. Recovery in the traditional decompression group was 35 of 62 (56%) dogs, and in the durotomy group 30 of 66 (45%) dogs, associated with an odds ratio of 0.643 (95% confidence interval: 0.320?1.292) and z-score of ?1.24. This z-score indicates trial futility to reach the target 15% improvement over traditional surgery, and the trial was terminated at this stage. We conclude that durotomy is ineffective in improving functional outcome for severe acute thoracolumbar SCI in dogs. In the future, these data can be compared with similar data from clinical trials on duraplasty in human patients and will aid in determining the predictive validity of the ?companion dog model? of acute SCI. |
| first_indexed | 2024-03-07T23:25:48Z |
| format | Article |
| id | doaj.art-8638cc97b5cd49858b378935d2047abf |
| institution | Directory Open Access Journal |
| issn | 2689-288X |
| language | English |
| last_indexed | 2024-03-07T23:25:48Z |
| publishDate | 2024-02-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj.art-8638cc97b5cd49858b378935d2047abf2024-02-21T04:00:34ZengMary Ann LiebertNeurotrauma Reports2689-288X2024-02-015112813810.1089/NEUR.2023.0129Randomized Controlled Trial of Durotomy as an Adjunct to Routine Decompressive Surgery for Dogs With Severe Acute Spinal Cord InjuryNick D. JefferyJohn H. RossmeislTom R. Harcourt-BrownNicolas GrangerDaisuke ItoKari FossDamian ChaseAlthough many interventions for acute spinal cord injury (SCI) appear promising in experimental models, translation directly from experimental animals to human patients is a large step that can be problematic. Acute SCI occurs frequently in companion dogs and may provide a model to ease translation. Recently, incision of the dura has been highlighted in both research animals and human patients as a means of reducing intraspinal pressure, with a view to improving perfusion of the injured tissue and enhancing functional recovery. Observational clinical data in humans and dogs support the notion that it may also improve functional outcome. Here, we report the results of a multi-center randomized controlled trial of durotomy as an adjunct to traditional decompressive surgery for treatment of severe thoracolumbar SCI caused by acute intervertebral disc herniation in dogs. Sample-size calculation was based on the proportion of dogs recovering ambulation improving from an expected 55% in the traditional surgery group to 70% in the durotomy group. Over a 3.5-year period, we enrolled 140 dogs, of which 128 had appropriate duration of follow-up. Overall, 65 (51%) dogs recovered ambulation. Recovery in the traditional decompression group was 35 of 62 (56%) dogs, and in the durotomy group 30 of 66 (45%) dogs, associated with an odds ratio of 0.643 (95% confidence interval: 0.320?1.292) and z-score of ?1.24. This z-score indicates trial futility to reach the target 15% improvement over traditional surgery, and the trial was terminated at this stage. We conclude that durotomy is ineffective in improving functional outcome for severe acute thoracolumbar SCI in dogs. In the future, these data can be compared with similar data from clinical trials on duraplasty in human patients and will aid in determining the predictive validity of the ?companion dog model? of acute SCI.https://www.liebertpub.com/doi/full/10.1089/NEUR.2023.0129caninedisc herniationdural incisionparaplegia |
| spellingShingle | Nick D. Jeffery John H. Rossmeisl Tom R. Harcourt-Brown Nicolas Granger Daisuke Ito Kari Foss Damian Chase Randomized Controlled Trial of Durotomy as an Adjunct to Routine Decompressive Surgery for Dogs With Severe Acute Spinal Cord Injury Neurotrauma Reports canine disc herniation dural incision paraplegia |
| title | Randomized Controlled Trial of Durotomy as an Adjunct to Routine Decompressive Surgery for Dogs With Severe Acute Spinal Cord Injury |
| title_full | Randomized Controlled Trial of Durotomy as an Adjunct to Routine Decompressive Surgery for Dogs With Severe Acute Spinal Cord Injury |
| title_fullStr | Randomized Controlled Trial of Durotomy as an Adjunct to Routine Decompressive Surgery for Dogs With Severe Acute Spinal Cord Injury |
| title_full_unstemmed | Randomized Controlled Trial of Durotomy as an Adjunct to Routine Decompressive Surgery for Dogs With Severe Acute Spinal Cord Injury |
| title_short | Randomized Controlled Trial of Durotomy as an Adjunct to Routine Decompressive Surgery for Dogs With Severe Acute Spinal Cord Injury |
| title_sort | randomized controlled trial of durotomy as an adjunct to routine decompressive surgery for dogs with severe acute spinal cord injury |
| topic | canine disc herniation dural incision paraplegia |
| url | https://www.liebertpub.com/doi/full/10.1089/NEUR.2023.0129 |
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