Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar
Neuropsychological and neuroimaging studies have suggested the presence of a fast, subcortical route for the processing of emotionally-salient visual information in the primate brain. This putative pathway consists of the superior colliculus (SC), pulvinar and amygdala. While the presence of such a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-10-01
|
| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncir.2018.00091/full |
| _version_ | 1818913687881121792 |
|---|---|
| author | Catherine Elorette Catherine Elorette Patrick A. Forcelli Patrick A. Forcelli Patrick A. Forcelli Richard C. Saunders Ludise Malkova Ludise Malkova |
| author_facet | Catherine Elorette Catherine Elorette Patrick A. Forcelli Patrick A. Forcelli Patrick A. Forcelli Richard C. Saunders Ludise Malkova Ludise Malkova |
| author_sort | Catherine Elorette |
| collection | DOAJ |
| description | Neuropsychological and neuroimaging studies have suggested the presence of a fast, subcortical route for the processing of emotionally-salient visual information in the primate brain. This putative pathway consists of the superior colliculus (SC), pulvinar and amygdala. While the presence of such a pathway has been confirmed in sub-primate species, it has yet to be documented in the primate brain using conventional anatomical methods. We injected retrograde tracers into the amygdala and anterograde tracers into the colliculus, and examined regions of colocalization of these signals within the pulvinar of the macaque. Anterograde tracers injected into the SC labeled axonal projections within the pulvinar, primarily within the oral, lateral and medial subdivisions. These axonal projections from the colliculus colocalized with cell bodies within the pulvinar that were labeled by retrograde tracer injected into the lateral amygdala. This zone of overlap was most notable in the medial portions of the medial (PM), oral (PO) and inferior pulvinar (PI), and was often densely concentrated in the vicinity of the brachium of the SC. These data provide an anatomical basis for the previously suggested pathway mediating fast processing of emotionally salient information. |
| first_indexed | 2024-12-19T23:34:27Z |
| format | Article |
| id | doaj.art-86395e0d3b624603bd7f37578c137b99 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-19T23:34:27Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-86395e0d3b624603bd7f37578c137b992022-12-21T20:01:39ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102018-10-011210.3389/fncir.2018.00091409498Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque PulvinarCatherine Elorette0Catherine Elorette1Patrick A. Forcelli2Patrick A. Forcelli3Patrick A. Forcelli4Richard C. Saunders5Ludise Malkova6Ludise Malkova7Interdisciplinary Program in Neuroscience, Georgetown University School of Medicine, Washington, DC, United StatesDepartment of Pharmacology and Physiology, Georgetown University School of Medicine, Washington, DC, United StatesInterdisciplinary Program in Neuroscience, Georgetown University School of Medicine, Washington, DC, United StatesDepartment of Pharmacology and Physiology, Georgetown University School of Medicine, Washington, DC, United StatesDepartment of Neuroscience, Georgetown University School of Medicine, Washington, DC, United StatesLaboratory of Neuropsychology, National Institute of Mental Health (NIMH), Bethesda, ML, United StatesInterdisciplinary Program in Neuroscience, Georgetown University School of Medicine, Washington, DC, United StatesDepartment of Pharmacology and Physiology, Georgetown University School of Medicine, Washington, DC, United StatesNeuropsychological and neuroimaging studies have suggested the presence of a fast, subcortical route for the processing of emotionally-salient visual information in the primate brain. This putative pathway consists of the superior colliculus (SC), pulvinar and amygdala. While the presence of such a pathway has been confirmed in sub-primate species, it has yet to be documented in the primate brain using conventional anatomical methods. We injected retrograde tracers into the amygdala and anterograde tracers into the colliculus, and examined regions of colocalization of these signals within the pulvinar of the macaque. Anterograde tracers injected into the SC labeled axonal projections within the pulvinar, primarily within the oral, lateral and medial subdivisions. These axonal projections from the colliculus colocalized with cell bodies within the pulvinar that were labeled by retrograde tracer injected into the lateral amygdala. This zone of overlap was most notable in the medial portions of the medial (PM), oral (PO) and inferior pulvinar (PI), and was often densely concentrated in the vicinity of the brachium of the SC. These data provide an anatomical basis for the previously suggested pathway mediating fast processing of emotionally salient information.https://www.frontiersin.org/article/10.3389/fncir.2018.00091/fullsubcorticalsuperior colliculusblindsightretrogradeanterogradeanatomy |
| spellingShingle | Catherine Elorette Catherine Elorette Patrick A. Forcelli Patrick A. Forcelli Patrick A. Forcelli Richard C. Saunders Ludise Malkova Ludise Malkova Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar Frontiers in Neural Circuits subcortical superior colliculus blindsight retrograde anterograde anatomy |
| title | Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar |
| title_full | Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar |
| title_fullStr | Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar |
| title_full_unstemmed | Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar |
| title_short | Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar |
| title_sort | colocalization of tectal inputs with amygdala projecting neurons in the macaque pulvinar |
| topic | subcortical superior colliculus blindsight retrograde anterograde anatomy |
| url | https://www.frontiersin.org/article/10.3389/fncir.2018.00091/full |
| work_keys_str_mv | AT catherineelorette colocalizationoftectalinputswithamygdalaprojectingneuronsinthemacaquepulvinar AT catherineelorette colocalizationoftectalinputswithamygdalaprojectingneuronsinthemacaquepulvinar AT patrickaforcelli colocalizationoftectalinputswithamygdalaprojectingneuronsinthemacaquepulvinar AT patrickaforcelli colocalizationoftectalinputswithamygdalaprojectingneuronsinthemacaquepulvinar AT patrickaforcelli colocalizationoftectalinputswithamygdalaprojectingneuronsinthemacaquepulvinar AT richardcsaunders colocalizationoftectalinputswithamygdalaprojectingneuronsinthemacaquepulvinar AT ludisemalkova colocalizationoftectalinputswithamygdalaprojectingneuronsinthemacaquepulvinar AT ludisemalkova colocalizationoftectalinputswithamygdalaprojectingneuronsinthemacaquepulvinar |