Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides
ABSTRACTFermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, including Leuconostoc mesenteroides; however, the exact mechanism...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2161271 |
| _version_ | 1827303737899614208 |
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| author | Junki Miyamoto Hidenori Shimizu Keiko Hisa Chiaki Matsuzaki Shinsuke Inuki Yuna Ando Akari Nishida Ayano Izumi Mayu Yamano Chihiro Ushiroda Junichiro Irie Takane Katayama Hiroaki Ohno Hiroshi Itoh Kenji Yamamoto Ikuo Kimura |
| author_facet | Junki Miyamoto Hidenori Shimizu Keiko Hisa Chiaki Matsuzaki Shinsuke Inuki Yuna Ando Akari Nishida Ayano Izumi Mayu Yamano Chihiro Ushiroda Junichiro Irie Takane Katayama Hiroaki Ohno Hiroshi Itoh Kenji Yamamoto Ikuo Kimura |
| author_sort | Junki Miyamoto |
| collection | DOAJ |
| description | ABSTRACTFermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, including Leuconostoc mesenteroides; however, the exact mechanism of action of these foods remains unclear. Here, we observed that prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) demonstrate substantial host metabolic benefits. L. mesenteroides-produced EPS is an indigestible α-glucan, and intake of the purified form of EPS improved glucose metabolism and energy homeostasis through EPS-derived gut microbial short-chain fatty acids, and changed gut microbial composition. Our findings reveal an important mechanism that accounts for the effects of diet, prebiotics, and probiotics on energy homeostasis and suggests an approach for preventing lifestyle-related diseases by targeting bacterial EPS. |
| first_indexed | 2024-03-11T14:20:30Z |
| format | Article |
| id | doaj.art-863ae83d61be4aebbe7696fd3bdeac9a |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:25Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-863ae83d61be4aebbe7696fd3bdeac9a2024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2022.2161271Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroidesJunki Miyamoto0Hidenori Shimizu1Keiko Hisa2Chiaki Matsuzaki3Shinsuke Inuki4Yuna Ando5Akari Nishida6Ayano Izumi7Mayu Yamano8Chihiro Ushiroda9Junichiro Irie10Takane Katayama11Hiroaki Ohno12Hiroshi Itoh13Kenji Yamamoto14Ikuo Kimura15Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, JapanAMED-CREST, Japan Agency for Medical Research and Development, Chiyoda-ku, JapanAMED-CREST, Japan Agency for Medical Research and Development, Chiyoda-ku, JapanResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Ishikawa, JapanAMED-CREST, Japan Agency for Medical Research and Development, Chiyoda-ku, JapanLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Kyoto, JapanDepartment of Molecular Neurobiology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, JapanDepartment of Molecular Neurobiology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, JapanDepartment of Molecular Neurobiology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, JapanDepartment of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, JapanAMED-CREST, Japan Agency for Medical Research and Development, Chiyoda-ku, JapanLaboratory of Molecular Biology and Bioresponse, Graduate School of Biostudies, Kyoto University, Kyoto, JapanAMED-CREST, Japan Agency for Medical Research and Development, Chiyoda-ku, JapanAMED-CREST, Japan Agency for Medical Research and Development, Chiyoda-ku, JapanCenter for Innovative and Joint Research, Wakayama University, Wakayama, JapanDepartment of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, JapanABSTRACTFermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, including Leuconostoc mesenteroides; however, the exact mechanism of action of these foods remains unclear. Here, we observed that prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) demonstrate substantial host metabolic benefits. L. mesenteroides-produced EPS is an indigestible α-glucan, and intake of the purified form of EPS improved glucose metabolism and energy homeostasis through EPS-derived gut microbial short-chain fatty acids, and changed gut microbial composition. Our findings reveal an important mechanism that accounts for the effects of diet, prebiotics, and probiotics on energy homeostasis and suggests an approach for preventing lifestyle-related diseases by targeting bacterial EPS.https://www.tandfonline.com/doi/10.1080/19490976.2022.2161271Exopolysaccharidesshort-chain fatty acidsdietary fiberprebioticsobesitygut microbiota |
| spellingShingle | Junki Miyamoto Hidenori Shimizu Keiko Hisa Chiaki Matsuzaki Shinsuke Inuki Yuna Ando Akari Nishida Ayano Izumi Mayu Yamano Chihiro Ushiroda Junichiro Irie Takane Katayama Hiroaki Ohno Hiroshi Itoh Kenji Yamamoto Ikuo Kimura Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides Gut Microbes Exopolysaccharides short-chain fatty acids dietary fiber prebiotics obesity gut microbiota |
| title | Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides |
| title_full | Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides |
| title_fullStr | Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides |
| title_full_unstemmed | Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides |
| title_short | Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides |
| title_sort | host metabolic benefits of prebiotic exopolysaccharides produced by leuconostoc mesenteroides |
| topic | Exopolysaccharides short-chain fatty acids dietary fiber prebiotics obesity gut microbiota |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2161271 |
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