Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects
Tissue engineering provides a powerful solution for current organ shortages, and researchers have cultured blood vessels, heart tissues, and bone tissues in vitro. However, traditional top-down tissue engineering has suffered two challenges: vascularization and reconfigurability of functional units....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/13/1/75 |
| _version_ | 1797491896930533376 |
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| author | Xiaowen Wang Zhen Wang Wenya Zhai Fengyun Wang Zhixing Ge Haibo Yu Wenguang Yang |
| author_facet | Xiaowen Wang Zhen Wang Wenya Zhai Fengyun Wang Zhixing Ge Haibo Yu Wenguang Yang |
| author_sort | Xiaowen Wang |
| collection | DOAJ |
| description | Tissue engineering provides a powerful solution for current organ shortages, and researchers have cultured blood vessels, heart tissues, and bone tissues in vitro. However, traditional top-down tissue engineering has suffered two challenges: vascularization and reconfigurability of functional units. With the continuous development of micro-nano technology and biomaterial technology, bottom-up tissue engineering as a promising approach for organ and tissue modular reconstruction has gradually developed. In this article, relevant advances in living blocks fabrication and assembly techniques for creation of higher-order bioarchitectures are described. After a critical overview of this technology, a discussion of practical challenges is provided, and future development prospects are proposed. |
| first_indexed | 2024-03-10T00:54:54Z |
| format | Article |
| id | doaj.art-863c2eb0345344f5a1cb96c3fec80ccf |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T00:54:54Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-863c2eb0345344f5a1cb96c3fec80ccf2023-11-23T14:44:28ZengMDPI AGMicromachines2072-666X2021-12-011317510.3390/mi13010075Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future ProspectsXiaowen Wang0Zhen Wang1Wenya Zhai2Fengyun Wang3Zhixing Ge4Haibo Yu5Wenguang Yang6School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, ChinaSchool of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, ChinaSchool of Energy and Materials Engineering, Shandong Polytechnic College, Jining 272000, ChinaSchool of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, ChinaState Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, ChinaState Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, ChinaSchool of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, ChinaTissue engineering provides a powerful solution for current organ shortages, and researchers have cultured blood vessels, heart tissues, and bone tissues in vitro. However, traditional top-down tissue engineering has suffered two challenges: vascularization and reconfigurability of functional units. With the continuous development of micro-nano technology and biomaterial technology, bottom-up tissue engineering as a promising approach for organ and tissue modular reconstruction has gradually developed. In this article, relevant advances in living blocks fabrication and assembly techniques for creation of higher-order bioarchitectures are described. After a critical overview of this technology, a discussion of practical challenges is provided, and future development prospects are proposed.https://www.mdpi.com/2072-666X/13/1/75bottom-up tissue engineeringdrug screeningmodular assemblymicro-fabrication |
| spellingShingle | Xiaowen Wang Zhen Wang Wenya Zhai Fengyun Wang Zhixing Ge Haibo Yu Wenguang Yang Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects Micromachines bottom-up tissue engineering drug screening modular assembly micro-fabrication |
| title | Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects |
| title_full | Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects |
| title_fullStr | Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects |
| title_full_unstemmed | Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects |
| title_short | Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects |
| title_sort | engineering biological tissues from the bottom up recent advances and future prospects |
| topic | bottom-up tissue engineering drug screening modular assembly micro-fabrication |
| url | https://www.mdpi.com/2072-666X/13/1/75 |
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