Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster Assembly
The Fe protein of nitrogenase plays multiple roles in substrate reduction and metallocluster assembly. Best known for its function to transfer electrons to its catalytic partner during nitrogenase catalysis, the Fe protein is also a key player in the biosynthesis of the complex metalloclusters of ni...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/19/6743 |
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| author | Markus W. Ribbe Kamil Górecki Mario Grosch Joseph B. Solomon Robert Quechol Yiling A. Liu Chi Chung Lee Yilin Hu |
| author_facet | Markus W. Ribbe Kamil Górecki Mario Grosch Joseph B. Solomon Robert Quechol Yiling A. Liu Chi Chung Lee Yilin Hu |
| author_sort | Markus W. Ribbe |
| collection | DOAJ |
| description | The Fe protein of nitrogenase plays multiple roles in substrate reduction and metallocluster assembly. Best known for its function to transfer electrons to its catalytic partner during nitrogenase catalysis, the Fe protein is also a key player in the biosynthesis of the complex metalloclusters of nitrogenase. In addition, it can function as a reductase on its own and affect the ambient reduction of CO<sub>2</sub> or CO to hydrocarbons. This review will provide an overview of the properties and functions of the Fe protein, highlighting the relevance of this unique FeS enzyme to areas related to the catalysis, biosynthesis, and applications of the fascinating nitrogenase system. |
| first_indexed | 2024-03-09T21:22:51Z |
| format | Article |
| id | doaj.art-863ea54278a548f1beba779c0d1dbffe |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:22:51Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-863ea54278a548f1beba779c0d1dbffe2023-11-23T21:16:33ZengMDPI AGMolecules1420-30492022-10-012719674310.3390/molecules27196743Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster AssemblyMarkus W. Ribbe0Kamil Górecki1Mario Grosch2Joseph B. Solomon3Robert Quechol4Yiling A. Liu5Chi Chung Lee6Yilin Hu7Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USADepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USADepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USADepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USADepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USADepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USADepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USADepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USAThe Fe protein of nitrogenase plays multiple roles in substrate reduction and metallocluster assembly. Best known for its function to transfer electrons to its catalytic partner during nitrogenase catalysis, the Fe protein is also a key player in the biosynthesis of the complex metalloclusters of nitrogenase. In addition, it can function as a reductase on its own and affect the ambient reduction of CO<sub>2</sub> or CO to hydrocarbons. This review will provide an overview of the properties and functions of the Fe protein, highlighting the relevance of this unique FeS enzyme to areas related to the catalysis, biosynthesis, and applications of the fascinating nitrogenase system.https://www.mdpi.com/1420-3049/27/19/6743nitrogenaseFe proteinreductasecatalysisbiosynthesisFeS enzyme |
| spellingShingle | Markus W. Ribbe Kamil Górecki Mario Grosch Joseph B. Solomon Robert Quechol Yiling A. Liu Chi Chung Lee Yilin Hu Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster Assembly Molecules nitrogenase Fe protein reductase catalysis biosynthesis FeS enzyme |
| title | Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster Assembly |
| title_full | Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster Assembly |
| title_fullStr | Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster Assembly |
| title_full_unstemmed | Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster Assembly |
| title_short | Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster Assembly |
| title_sort | nitrogenase fe protein a multi tasking player in substrate reduction and metallocluster assembly |
| topic | nitrogenase Fe protein reductase catalysis biosynthesis FeS enzyme |
| url | https://www.mdpi.com/1420-3049/27/19/6743 |
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