Biomarkers of Coagulation and Inflammation in Dogs after Randomized Administration of 6% Hydroxyethyl Starch 130/0.4 or Hartmann’s Solution
Synthetic colloid fluids containing hydroxyethyl starch (HES) have been associated with impairment of coagulation in dogs. It is unknown if HES causes coagulation impairment in dogs with naturally occurring critical illness. This study used banked plasma samples from a blinded, randomized clinical t...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/19/2691 |
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| author | Corrin J. Boyd Anthea L. Raisis Claire R. Sharp Melissa A. Claus Giselle Hosgood Lisa Smart |
| author_facet | Corrin J. Boyd Anthea L. Raisis Claire R. Sharp Melissa A. Claus Giselle Hosgood Lisa Smart |
| author_sort | Corrin J. Boyd |
| collection | DOAJ |
| description | Synthetic colloid fluids containing hydroxyethyl starch (HES) have been associated with impairment of coagulation in dogs. It is unknown if HES causes coagulation impairment in dogs with naturally occurring critical illness. This study used banked plasma samples from a blinded, randomized clinical trial comparing HES and balanced isotonic crystalloid for bolus fluid therapy in 39 critically ill dogs. Blood was collected prior to fluid administration and 6, 12, and 24 h thereafter. Coagulation biomarkers measured at each time point included prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen concentration, and the activities of coagulation factors V, VII, VIII, IX, and X, von Willebrand factor antigen, antithrombin, and protein C. Given the links between coagulation and inflammation, cytokine concentrations were also measured, including interleukins 6, 8, 10, and 18, keratinocyte-derived chemokine, and monocyte chemoattractant protein-1. Data were analyzed with linear mixed effects models. No significant treatment-by-time interactions were found for any biomarker, indicating that the pattern of change over time was not modified by treatment. Examining the main effect of time showed significant changes in several coagulation biomarkers and keratinocyte-derived chemokines. This study could not detect evidence of coagulation impairment with HES. |
| first_indexed | 2024-03-09T22:07:33Z |
| format | Article |
| id | doaj.art-863fdd982a234fd993b105ca30aaa52f |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T22:07:33Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-863fdd982a234fd993b105ca30aaa52f2023-11-23T19:38:10ZengMDPI AGAnimals2076-26152022-10-011219269110.3390/ani12192691Biomarkers of Coagulation and Inflammation in Dogs after Randomized Administration of 6% Hydroxyethyl Starch 130/0.4 or Hartmann’s SolutionCorrin J. Boyd0Anthea L. Raisis1Claire R. Sharp2Melissa A. Claus3Giselle Hosgood4Lisa Smart5School of Veterinary Medicine, Murdoch University, Perth, WA 6150, AustraliaSchool of Veterinary Medicine, Murdoch University, Perth, WA 6150, AustraliaSchool of Veterinary Medicine, Murdoch University, Perth, WA 6150, AustraliaSchool of Veterinary Medicine, Murdoch University, Perth, WA 6150, AustraliaSchool of Veterinary Medicine, Murdoch University, Perth, WA 6150, AustraliaSchool of Veterinary Medicine, Murdoch University, Perth, WA 6150, AustraliaSynthetic colloid fluids containing hydroxyethyl starch (HES) have been associated with impairment of coagulation in dogs. It is unknown if HES causes coagulation impairment in dogs with naturally occurring critical illness. This study used banked plasma samples from a blinded, randomized clinical trial comparing HES and balanced isotonic crystalloid for bolus fluid therapy in 39 critically ill dogs. Blood was collected prior to fluid administration and 6, 12, and 24 h thereafter. Coagulation biomarkers measured at each time point included prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen concentration, and the activities of coagulation factors V, VII, VIII, IX, and X, von Willebrand factor antigen, antithrombin, and protein C. Given the links between coagulation and inflammation, cytokine concentrations were also measured, including interleukins 6, 8, 10, and 18, keratinocyte-derived chemokine, and monocyte chemoattractant protein-1. Data were analyzed with linear mixed effects models. No significant treatment-by-time interactions were found for any biomarker, indicating that the pattern of change over time was not modified by treatment. Examining the main effect of time showed significant changes in several coagulation biomarkers and keratinocyte-derived chemokines. This study could not detect evidence of coagulation impairment with HES.https://www.mdpi.com/2076-2615/12/19/2691activated partial thromboplastin timecoagulation factorcolloidcrystalloidcytokinefibrinogen |
| spellingShingle | Corrin J. Boyd Anthea L. Raisis Claire R. Sharp Melissa A. Claus Giselle Hosgood Lisa Smart Biomarkers of Coagulation and Inflammation in Dogs after Randomized Administration of 6% Hydroxyethyl Starch 130/0.4 or Hartmann’s Solution Animals activated partial thromboplastin time coagulation factor colloid crystalloid cytokine fibrinogen |
| title | Biomarkers of Coagulation and Inflammation in Dogs after Randomized Administration of 6% Hydroxyethyl Starch 130/0.4 or Hartmann’s Solution |
| title_full | Biomarkers of Coagulation and Inflammation in Dogs after Randomized Administration of 6% Hydroxyethyl Starch 130/0.4 or Hartmann’s Solution |
| title_fullStr | Biomarkers of Coagulation and Inflammation in Dogs after Randomized Administration of 6% Hydroxyethyl Starch 130/0.4 or Hartmann’s Solution |
| title_full_unstemmed | Biomarkers of Coagulation and Inflammation in Dogs after Randomized Administration of 6% Hydroxyethyl Starch 130/0.4 or Hartmann’s Solution |
| title_short | Biomarkers of Coagulation and Inflammation in Dogs after Randomized Administration of 6% Hydroxyethyl Starch 130/0.4 or Hartmann’s Solution |
| title_sort | biomarkers of coagulation and inflammation in dogs after randomized administration of 6 hydroxyethyl starch 130 0 4 or hartmann s solution |
| topic | activated partial thromboplastin time coagulation factor colloid crystalloid cytokine fibrinogen |
| url | https://www.mdpi.com/2076-2615/12/19/2691 |
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