Optimizing the use of angiogenesis inhibitor in neovascular age-related macular degeneration
The purpose of the study was to estimate the effectiveness of using ranibizumab in combination with medotilin drug in the treatment of neovascular age-related macular degeneration (AMD). Material and methods. 50 patients (65 eyes) aged 41 to 88 (ave. 68.5 ± 0.98 years) with neovascular AMD were foll...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2018-10-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/69 |
| _version_ | 1797878360338071552 |
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| author | F. A. Bakhritdinova A. F. Yusupov Sh. A. Mukhanov |
| author_facet | F. A. Bakhritdinova A. F. Yusupov Sh. A. Mukhanov |
| author_sort | F. A. Bakhritdinova |
| collection | DOAJ |
| description | The purpose of the study was to estimate the effectiveness of using ranibizumab in combination with medotilin drug in the treatment of neovascular age-related macular degeneration (AMD). Material and methods. 50 patients (65 eyes) aged 41 to 88 (ave. 68.5 ± 0.98 years) with neovascular AMD were followed-up. All patients were assigned treatment consisting of three intravitreal ranibizumab injections with an interval of 1 month between injections. Of these, 25 patients (34 eyes) were additionally given 4 ml of medotilin intramuscularly once a day for 10 days. Results. Combined treatment with ranibizumab and medotilin showed a statistically significant improvement of functional parameters: visual acuity, light sensitivity and flicker ERG as compared to the control group. Conclusion. Medotilin, which has neuroprotective action, enhances the effect of angiogenesis inhibitors drugs in all forms of neovascular AMD and promotes statistically significant increase of the functional condition of the central retina area, which is confirmed by electroretinography data // Russian Ophthalmological Journal, 2017; 1: 9-14. doi: 10.21516/2072-0076-2017-10-1-9-14. |
| first_indexed | 2024-04-10T02:31:32Z |
| format | Article |
| id | doaj.art-86402188e28641ebb7903f90fd3dca03 |
| institution | Directory Open Access Journal |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| last_indexed | 2024-04-10T02:31:32Z |
| publishDate | 2018-10-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj.art-86402188e28641ebb7903f90fd3dca032023-03-13T07:54:28ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602018-10-0110191410.21516/2072-0076-2017-10-1-9-1469Optimizing the use of angiogenesis inhibitor in neovascular age-related macular degenerationF. A. Bakhritdinova0A. F. Yusupov1Sh. A. Mukhanov2Ташкентская медицинская академия, Министерство здравоохранения Республики УзбекистанСП ООО «SIHAT KO’Z», Ташкент, УзбекистанСП ООО «SIHAT KO’Z», Ташкент, УзбекистанThe purpose of the study was to estimate the effectiveness of using ranibizumab in combination with medotilin drug in the treatment of neovascular age-related macular degeneration (AMD). Material and methods. 50 patients (65 eyes) aged 41 to 88 (ave. 68.5 ± 0.98 years) with neovascular AMD were followed-up. All patients were assigned treatment consisting of three intravitreal ranibizumab injections with an interval of 1 month between injections. Of these, 25 patients (34 eyes) were additionally given 4 ml of medotilin intramuscularly once a day for 10 days. Results. Combined treatment with ranibizumab and medotilin showed a statistically significant improvement of functional parameters: visual acuity, light sensitivity and flicker ERG as compared to the control group. Conclusion. Medotilin, which has neuroprotective action, enhances the effect of angiogenesis inhibitors drugs in all forms of neovascular AMD and promotes statistically significant increase of the functional condition of the central retina area, which is confirmed by electroretinography data // Russian Ophthalmological Journal, 2017; 1: 9-14. doi: 10.21516/2072-0076-2017-10-1-9-14.https://roj.igb.ru/jour/article/view/69возрастная макулярная дегенерацияхроническая неоваскуляризацияранибизумабмедотилинэлектроретинографияage-related macular degenerationchronic neovascularizationranibizumabmedotilinelectroretinography |
| spellingShingle | F. A. Bakhritdinova A. F. Yusupov Sh. A. Mukhanov Optimizing the use of angiogenesis inhibitor in neovascular age-related macular degeneration Российский офтальмологический журнал возрастная макулярная дегенерация хроническая неоваскуляризация ранибизумаб медотилин электроретинография age-related macular degeneration chronic neovascularization ranibizumab medotilin electroretinography |
| title | Optimizing the use of angiogenesis inhibitor in neovascular age-related macular degeneration |
| title_full | Optimizing the use of angiogenesis inhibitor in neovascular age-related macular degeneration |
| title_fullStr | Optimizing the use of angiogenesis inhibitor in neovascular age-related macular degeneration |
| title_full_unstemmed | Optimizing the use of angiogenesis inhibitor in neovascular age-related macular degeneration |
| title_short | Optimizing the use of angiogenesis inhibitor in neovascular age-related macular degeneration |
| title_sort | optimizing the use of angiogenesis inhibitor in neovascular age related macular degeneration |
| topic | возрастная макулярная дегенерация хроническая неоваскуляризация ранибизумаб медотилин электроретинография age-related macular degeneration chronic neovascularization ranibizumab medotilin electroretinography |
| url | https://roj.igb.ru/jour/article/view/69 |
| work_keys_str_mv | AT fabakhritdinova optimizingtheuseofangiogenesisinhibitorinneovascularagerelatedmaculardegeneration AT afyusupov optimizingtheuseofangiogenesisinhibitorinneovascularagerelatedmaculardegeneration AT shamukhanov optimizingtheuseofangiogenesisinhibitorinneovascularagerelatedmaculardegeneration |