Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential
Exosomes are nanovesicles secreted into biofluids by various cell types and have been implicated in different physiological and pathological processes. Interestingly, a plethora of studies emphasized the mediating role of exosomes in the bidirectional communication between donor and recipient cells....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/1/286 |
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| author | Wenqin Zhang Yuanliang Yan Jinwu Peng Abhimanyu Thakur Ning Bai Keda Yang Zhijie Xu |
| author_facet | Wenqin Zhang Yuanliang Yan Jinwu Peng Abhimanyu Thakur Ning Bai Keda Yang Zhijie Xu |
| author_sort | Wenqin Zhang |
| collection | DOAJ |
| description | Exosomes are nanovesicles secreted into biofluids by various cell types and have been implicated in different physiological and pathological processes. Interestingly, a plethora of studies emphasized the mediating role of exosomes in the bidirectional communication between donor and recipient cells. Among the various cargoes of exosomes, long non-coding RNAs (lncRNAs) have been identified as crucial regulators between cancer cells and immune cells in the tumor microenvironment (TME) that can interfere with innate and adaptive immune responses to affect the therapeutic efficiency. Recently, a few major studies have focused on the exosomal lncRNA-mediated interaction between cancer cells and immune cells infiltrated into TME. Nevertheless, a dearth of studies pertains to the immune regulating role of exosomal lncRNAs in cancer and is still in the early stages. Comprehensive mechanisms of exosomal lncRNAs in tumor immunity are not well understood. Herein, we provide an overview of the immunomodulatory function of exosomal lncRNAs in cancer and treatment resistance. In addition, we also summarize the potential therapeutic strategies toward exosomal lncRNAs in TME. |
| first_indexed | 2024-03-11T10:05:58Z |
| format | Article |
| id | doaj.art-8640bdb104574479824e1f1e69cd1425 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T10:05:58Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8640bdb104574479824e1f1e69cd14252023-11-16T15:04:10ZengMDPI AGCancers2072-66942022-12-0115128610.3390/cancers15010286Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic PotentialWenqin Zhang0Yuanliang Yan1Jinwu Peng2Abhimanyu Thakur3Ning Bai4Keda Yang5Zhijie Xu6Department of Pathology, Xiangya Changde Hospital, Changde 415000, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaBen May Department for Cancer Research, Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USADepartment of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaExosomes are nanovesicles secreted into biofluids by various cell types and have been implicated in different physiological and pathological processes. Interestingly, a plethora of studies emphasized the mediating role of exosomes in the bidirectional communication between donor and recipient cells. Among the various cargoes of exosomes, long non-coding RNAs (lncRNAs) have been identified as crucial regulators between cancer cells and immune cells in the tumor microenvironment (TME) that can interfere with innate and adaptive immune responses to affect the therapeutic efficiency. Recently, a few major studies have focused on the exosomal lncRNA-mediated interaction between cancer cells and immune cells infiltrated into TME. Nevertheless, a dearth of studies pertains to the immune regulating role of exosomal lncRNAs in cancer and is still in the early stages. Comprehensive mechanisms of exosomal lncRNAs in tumor immunity are not well understood. Herein, we provide an overview of the immunomodulatory function of exosomal lncRNAs in cancer and treatment resistance. In addition, we also summarize the potential therapeutic strategies toward exosomal lncRNAs in TME.https://www.mdpi.com/2072-6694/15/1/286cancerexosomeslncRNAimmunoregulationimmunotherapy |
| spellingShingle | Wenqin Zhang Yuanliang Yan Jinwu Peng Abhimanyu Thakur Ning Bai Keda Yang Zhijie Xu Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential Cancers cancer exosomes lncRNA immunoregulation immunotherapy |
| title | Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential |
| title_full | Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential |
| title_fullStr | Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential |
| title_full_unstemmed | Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential |
| title_short | Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential |
| title_sort | decoding roles of exosomal lncrnas in tumor immune regulation and therapeutic potential |
| topic | cancer exosomes lncRNA immunoregulation immunotherapy |
| url | https://www.mdpi.com/2072-6694/15/1/286 |
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