The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation

The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation

Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA from viruses or self-DNA from mitochondria/nuclei. Recently, gain-of-function mutations in STING have been identified in patients with STING-associated vasculopathy with onset in infancy (...

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Bibliographic Details
Main Authors: Ruri Shindo, Yoshihiko Kuchitsu, Kojiro Mukai, Tomohiko Taguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
STING
STING-associated vasculopathy with onset in infancy (SAVI)
membrane traffic
interferonopathy
endoplasmic reticulum (ER)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1037999/full

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