Genetics Underlying the Interactions between Neural Crest Cells and Eye Development
The neural crest is a unique, transient stem cell population that is critical for craniofacial and ocular development. Understanding the genetics underlying the steps of neural crest development is essential for gaining insight into the pathogenesis of congenital eye diseases. The neural crest cells...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Developmental Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2221-3759/8/4/26 |
| _version_ | 1797548339664781312 |
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| author | Jochen Weigele Brenda L. Bohnsack |
| author_facet | Jochen Weigele Brenda L. Bohnsack |
| author_sort | Jochen Weigele |
| collection | DOAJ |
| description | The neural crest is a unique, transient stem cell population that is critical for craniofacial and ocular development. Understanding the genetics underlying the steps of neural crest development is essential for gaining insight into the pathogenesis of congenital eye diseases. The neural crest cells play an under-appreciated key role in patterning the neural epithelial-derived optic cup. These interactions between neural crest cells within the periocular mesenchyme and the optic cup, while not well-studied, are critical for optic cup morphogenesis and ocular fissure closure. As a result, microphthalmia and coloboma are common phenotypes in human disease and animal models in which neural crest cell specification and early migration are disrupted. In addition, neural crest cells directly contribute to numerous ocular structures including the cornea, iris, sclera, ciliary body, trabecular meshwork, and aqueous outflow tracts. Defects in later neural crest cell migration and differentiation cause a constellation of well-recognized ocular anterior segment anomalies such as Axenfeld–Rieger Syndrome and Peters Anomaly. This review will focus on the genetics of the neural crest cells within the context of how these complex processes specifically affect overall ocular development and can lead to congenital eye diseases. |
| first_indexed | 2024-03-10T14:57:59Z |
| format | Article |
| id | doaj.art-86434ccfabbc4de295f8ad455d395568 |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-03-10T14:57:59Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-86434ccfabbc4de295f8ad455d3955682023-11-20T20:27:21ZengMDPI AGJournal of Developmental Biology2221-37592020-11-01842610.3390/jdb8040026Genetics Underlying the Interactions between Neural Crest Cells and Eye DevelopmentJochen Weigele0Brenda L. Bohnsack1Division of Ophthalmology, Ann & Robert H. Lurie Children’s Hospital of Chicago, 225 E. Chicago Ave, Chicago, IL 60611, USADivision of Ophthalmology, Ann & Robert H. Lurie Children’s Hospital of Chicago, 225 E. Chicago Ave, Chicago, IL 60611, USAThe neural crest is a unique, transient stem cell population that is critical for craniofacial and ocular development. Understanding the genetics underlying the steps of neural crest development is essential for gaining insight into the pathogenesis of congenital eye diseases. The neural crest cells play an under-appreciated key role in patterning the neural epithelial-derived optic cup. These interactions between neural crest cells within the periocular mesenchyme and the optic cup, while not well-studied, are critical for optic cup morphogenesis and ocular fissure closure. As a result, microphthalmia and coloboma are common phenotypes in human disease and animal models in which neural crest cell specification and early migration are disrupted. In addition, neural crest cells directly contribute to numerous ocular structures including the cornea, iris, sclera, ciliary body, trabecular meshwork, and aqueous outflow tracts. Defects in later neural crest cell migration and differentiation cause a constellation of well-recognized ocular anterior segment anomalies such as Axenfeld–Rieger Syndrome and Peters Anomaly. This review will focus on the genetics of the neural crest cells within the context of how these complex processes specifically affect overall ocular development and can lead to congenital eye diseases.https://www.mdpi.com/2221-3759/8/4/26neural crestoptic cupcolobomamicrophthalmiaAxenfeld-Rieger SyndromePeters Anomaly |
| spellingShingle | Jochen Weigele Brenda L. Bohnsack Genetics Underlying the Interactions between Neural Crest Cells and Eye Development Journal of Developmental Biology neural crest optic cup coloboma microphthalmia Axenfeld-Rieger Syndrome Peters Anomaly |
| title | Genetics Underlying the Interactions between Neural Crest Cells and Eye Development |
| title_full | Genetics Underlying the Interactions between Neural Crest Cells and Eye Development |
| title_fullStr | Genetics Underlying the Interactions between Neural Crest Cells and Eye Development |
| title_full_unstemmed | Genetics Underlying the Interactions between Neural Crest Cells and Eye Development |
| title_short | Genetics Underlying the Interactions between Neural Crest Cells and Eye Development |
| title_sort | genetics underlying the interactions between neural crest cells and eye development |
| topic | neural crest optic cup coloboma microphthalmia Axenfeld-Rieger Syndrome Peters Anomaly |
| url | https://www.mdpi.com/2221-3759/8/4/26 |
| work_keys_str_mv | AT jochenweigele geneticsunderlyingtheinteractionsbetweenneuralcrestcellsandeyedevelopment AT brendalbohnsack geneticsunderlyingtheinteractionsbetweenneuralcrestcellsandeyedevelopment |