Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges
Drug discovery and development has become longer and costlier process. The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards “me too” drugs and improved generics (505(b) (2)) fillings. The discontinuance of molecules at late stage clinical trials is...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-02-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383513001081 |
| _version_ | 1818897135786000384 |
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| author | Basavaraj S Guru V. Betageri |
| author_facet | Basavaraj S Guru V. Betageri |
| author_sort | Basavaraj S |
| collection | DOAJ |
| description | Drug discovery and development has become longer and costlier process. The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards “me too” drugs and improved generics (505(b) (2)) fillings. The discontinuance of molecules at late stage clinical trials is common these years. The molecules are withdrawn at various stages of discovery and development process for reasons such as poor ADME properties, lack of efficacy and safety reasons. Hence this review focuses on possible applications of formulation and drug delivery to salvage molecules and improve the drugability. The formulation and drug delivery technologies are suitable for addressing various issues contributing to attrition are discussed in detail. |
| first_indexed | 2024-12-19T19:11:22Z |
| format | Article |
| id | doaj.art-8645c06b48934fc5b108a32703d5ce9d |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-19T19:11:22Z |
| publishDate | 2014-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-8645c06b48934fc5b108a32703d5ce9d2022-12-21T20:09:16ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432014-02-014131710.1016/j.apsb.2013.12.003Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challengesBasavaraj SGuru V. BetageriDrug discovery and development has become longer and costlier process. The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards “me too” drugs and improved generics (505(b) (2)) fillings. The discontinuance of molecules at late stage clinical trials is common these years. The molecules are withdrawn at various stages of discovery and development process for reasons such as poor ADME properties, lack of efficacy and safety reasons. Hence this review focuses on possible applications of formulation and drug delivery to salvage molecules and improve the drugability. The formulation and drug delivery technologies are suitable for addressing various issues contributing to attrition are discussed in detail.http://www.sciencedirect.com/science/article/pii/S2211383513001081Drug discovery and developmentDrugabilityFormulationDrug delivery technology |
| spellingShingle | Basavaraj S Guru V. Betageri Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges Acta Pharmaceutica Sinica B Drug discovery and development Drugability Formulation Drug delivery technology |
| title | Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges |
| title_full | Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges |
| title_fullStr | Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges |
| title_full_unstemmed | Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges |
| title_short | Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges |
| title_sort | can formulation and drug delivery reduce attrition during drug discovery and development review of feasibility benefits and challenges |
| topic | Drug discovery and development Drugability Formulation Drug delivery technology |
| url | http://www.sciencedirect.com/science/article/pii/S2211383513001081 |
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