Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's disease
Parkinson's disease (PD) is a common neurodegenerative disease and the disease burden is increasing. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons which may serve as a biomarker for axonal damage. NfL is one of the most prom...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2022-04-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2479 |
| _version_ | 1828342912507707392 |
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| author | YIN Wei⁃fang REN Hui YANG Xing⁃long |
| author_facet | YIN Wei⁃fang REN Hui YANG Xing⁃long |
| author_sort | YIN Wei⁃fang |
| collection | DOAJ |
| description | Parkinson's disease (PD) is a common neurodegenerative disease and the disease burden is increasing. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons which may serve as a biomarker for axonal damage. NfL is one of the most promising biomarkers to be used in clinical diagnosis and differential diagnosis of PD and it also plays an important role in predicting the severity and progression of PD and associated cognitive disorders. Besides, NfL combined imaging biomarkers also has high predictive value. This review provides an overview of the progress achieved thus far exploring the assicaiton between NfL in cerebrospinal fluid or blood, with a view to be providing help for clinical practice and follow⁃up studies. |
| first_indexed | 2024-04-13T23:35:32Z |
| format | Article |
| id | doaj.art-8646db84c74742f2a353f62d29d51eef |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-04-13T23:35:32Z |
| publishDate | 2022-04-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-8646db84c74742f2a353f62d29d51eef2022-12-22T02:24:46ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312022-04-0122422422810.3969/j.issn.1672⁃6731.2022.04.002Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's diseaseYIN Wei⁃fang0REN Hui1YANG Xing⁃long2Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical UniversityDepartment of Geriatric Neurology, First Affiliated Hospital of Kunming Medical UniversityDepartment of Geriatric Neurology, First Affiliated Hospital of Kunming Medical UniversityParkinson's disease (PD) is a common neurodegenerative disease and the disease burden is increasing. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons which may serve as a biomarker for axonal damage. NfL is one of the most promising biomarkers to be used in clinical diagnosis and differential diagnosis of PD and it also plays an important role in predicting the severity and progression of PD and associated cognitive disorders. Besides, NfL combined imaging biomarkers also has high predictive value. This review provides an overview of the progress achieved thus far exploring the assicaiton between NfL in cerebrospinal fluid or blood, with a view to be providing help for clinical practice and follow⁃up studies.http://www.cjcnn.org/index.php/cjcnn/article/view/2479parkinson diseaseneurofilament proteinsbiomarkersreview |
| spellingShingle | YIN Wei⁃fang REN Hui YANG Xing⁃long Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's disease Chinese Journal of Contemporary Neurology and Neurosurgery parkinson disease neurofilament proteins biomarkers review |
| title | Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's disease |
| title_full | Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's disease |
| title_fullStr | Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's disease |
| title_full_unstemmed | Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's disease |
| title_short | Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's disease |
| title_sort | research progression of neurofilament light chain in the diagnosis and differential diagnosis of parkinson s disease |
| topic | parkinson disease neurofilament proteins biomarkers review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2479 |
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