On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI
Primary glioblastoma (GBM), IDH-wildtype, especially with multifocal appearance/growth (mGBM), is associated with very poor prognosis. Several clinical parameters have been identified to provide prognostic value in both unifocal GBM (uGBM) and mGBM, but information about the influence of radiologica...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/28/2/136 |
| _version_ | 1797520755742736384 |
|---|---|
| author | Johannes Kasper Nicole Hilbert Tim Wende Michael Karl Fehrenbach Florian Wilhelmy Katja Jähne Clara Frydrychowicz Gordian Hamerla Jürgen Meixensberger Felix Arlt |
| author_facet | Johannes Kasper Nicole Hilbert Tim Wende Michael Karl Fehrenbach Florian Wilhelmy Katja Jähne Clara Frydrychowicz Gordian Hamerla Jürgen Meixensberger Felix Arlt |
| author_sort | Johannes Kasper |
| collection | DOAJ |
| description | Primary glioblastoma (GBM), IDH-wildtype, especially with multifocal appearance/growth (mGBM), is associated with very poor prognosis. Several clinical parameters have been identified to provide prognostic value in both unifocal GBM (uGBM) and mGBM, but information about the influence of radiological parameters on survival for mGBM cohorts is scarce. This study evaluated the prognostic value of several volumetric parameters derived from magnetic resonance imaging (MRI). Data from the Department of Neurosurgery, Leipzig University Hospital, were retrospectively analyzed. Patients treated between 2014 and 2019, aged older than 18 years and with adequate peri-operative MRI were included. Volumetric assessment was performed manually. One hundred and eighty-three patients were included. Survival of patients with mGBM was significantly shorter (<i>p</i> < 0.0001). Univariate analysis revealed extent of resection, adjuvant therapy regimen, residual tumor volume, tumor necrosis volume and ratio of tumor necrosis to initial volume as statistically significant for overall survival. In multivariate Cox regression, however, only EOR (for uGBM and the entire cohort) and adjuvant therapy were independently significant for survival. Decreased ratio of tumor necrosis to initial tumor volume and extent of resection were associated with prolonged survival in mGBM but failed to achieve statistical significance in multivariate analysis. |
| first_indexed | 2024-03-10T08:01:07Z |
| format | Article |
| id | doaj.art-86473a066bf2454bbd7340128f5333aa |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T08:01:07Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-86473a066bf2454bbd7340128f5333aa2023-11-22T11:29:07ZengMDPI AGCurrent Oncology1198-00521718-77292021-04-012821437144610.3390/curroncol28020136On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRIJohannes Kasper0Nicole Hilbert1Tim Wende2Michael Karl Fehrenbach3Florian Wilhelmy4Katja Jähne5Clara Frydrychowicz6Gordian Hamerla7Jürgen Meixensberger8Felix Arlt9Department of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyDivision of Neuropathology, University Hospital Leipzig, Liebigstraße 26, 04103 Leipzig, GermanyInstitute of Neuroradiology, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyPrimary glioblastoma (GBM), IDH-wildtype, especially with multifocal appearance/growth (mGBM), is associated with very poor prognosis. Several clinical parameters have been identified to provide prognostic value in both unifocal GBM (uGBM) and mGBM, but information about the influence of radiological parameters on survival for mGBM cohorts is scarce. This study evaluated the prognostic value of several volumetric parameters derived from magnetic resonance imaging (MRI). Data from the Department of Neurosurgery, Leipzig University Hospital, were retrospectively analyzed. Patients treated between 2014 and 2019, aged older than 18 years and with adequate peri-operative MRI were included. Volumetric assessment was performed manually. One hundred and eighty-three patients were included. Survival of patients with mGBM was significantly shorter (<i>p</i> < 0.0001). Univariate analysis revealed extent of resection, adjuvant therapy regimen, residual tumor volume, tumor necrosis volume and ratio of tumor necrosis to initial volume as statistically significant for overall survival. In multivariate Cox regression, however, only EOR (for uGBM and the entire cohort) and adjuvant therapy were independently significant for survival. Decreased ratio of tumor necrosis to initial tumor volume and extent of resection were associated with prolonged survival in mGBM but failed to achieve statistical significance in multivariate analysis.https://www.mdpi.com/1718-7729/28/2/136glioblastomavolumetric assessmentmultifocal glioblastoma |
| spellingShingle | Johannes Kasper Nicole Hilbert Tim Wende Michael Karl Fehrenbach Florian Wilhelmy Katja Jähne Clara Frydrychowicz Gordian Hamerla Jürgen Meixensberger Felix Arlt On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI Current Oncology glioblastoma volumetric assessment multifocal glioblastoma |
| title | On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI |
| title_full | On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI |
| title_fullStr | On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI |
| title_full_unstemmed | On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI |
| title_short | On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI |
| title_sort | on the prognosis of multifocal glioblastoma an evaluation incorporating volumetric mri |
| topic | glioblastoma volumetric assessment multifocal glioblastoma |
| url | https://www.mdpi.com/1718-7729/28/2/136 |
| work_keys_str_mv | AT johanneskasper ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri AT nicolehilbert ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri AT timwende ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri AT michaelkarlfehrenbach ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri AT florianwilhelmy ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri AT katjajahne ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri AT clarafrydrychowicz ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri AT gordianhamerla ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri AT jurgenmeixensberger ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri AT felixarlt ontheprognosisofmultifocalglioblastomaanevaluationincorporatingvolumetricmri |