Lytic granule exocytosis at immune synapses: lessons from neuronal synapses
Regulated exocytosis is a central mechanism of cellular communication. It is not only the basis for neurotransmission and hormone release, but also plays an important role in the immune system for the release of cytokines and cytotoxic molecules. In cytotoxic T lymphocytes (CTLs), the formation of t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1177670/full |
| _version_ | 1797824043717492736 |
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| author | Hsin-Fang Chang Claudia Schirra Varsha Pattu Elmar Krause Ute Becherer |
| author_facet | Hsin-Fang Chang Claudia Schirra Varsha Pattu Elmar Krause Ute Becherer |
| author_sort | Hsin-Fang Chang |
| collection | DOAJ |
| description | Regulated exocytosis is a central mechanism of cellular communication. It is not only the basis for neurotransmission and hormone release, but also plays an important role in the immune system for the release of cytokines and cytotoxic molecules. In cytotoxic T lymphocytes (CTLs), the formation of the immunological synapse is required for the delivery of the cytotoxic substances such as granzymes and perforin, which are stored in lytic granules and released via exocytosis. The molecular mechanisms of their fusion with the plasma membrane are only partially understood. In this review, we discuss the molecular players involved in the regulated exocytosis of CTL, highlighting the parallels and differences to neuronal synaptic transmission. Additionally, we examine the strengths and weaknesses of both systems to study exocytosis. |
| first_indexed | 2024-03-13T10:33:07Z |
| format | Article |
| id | doaj.art-86486fede6ac43a3891e5c025c5acbab |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T10:33:07Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-86486fede6ac43a3891e5c025c5acbab2023-05-18T08:16:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11776701177670Lytic granule exocytosis at immune synapses: lessons from neuronal synapsesHsin-Fang ChangClaudia SchirraVarsha PattuElmar KrauseUte BechererRegulated exocytosis is a central mechanism of cellular communication. It is not only the basis for neurotransmission and hormone release, but also plays an important role in the immune system for the release of cytokines and cytotoxic molecules. In cytotoxic T lymphocytes (CTLs), the formation of the immunological synapse is required for the delivery of the cytotoxic substances such as granzymes and perforin, which are stored in lytic granules and released via exocytosis. The molecular mechanisms of their fusion with the plasma membrane are only partially understood. In this review, we discuss the molecular players involved in the regulated exocytosis of CTL, highlighting the parallels and differences to neuronal synaptic transmission. Additionally, we examine the strengths and weaknesses of both systems to study exocytosis.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1177670/fullsynapseCD8+ cellscytotoxic T lymphocytesneuronexocytosisendocytosis |
| spellingShingle | Hsin-Fang Chang Claudia Schirra Varsha Pattu Elmar Krause Ute Becherer Lytic granule exocytosis at immune synapses: lessons from neuronal synapses Frontiers in Immunology synapse CD8+ cells cytotoxic T lymphocytes neuron exocytosis endocytosis |
| title | Lytic granule exocytosis at immune synapses: lessons from neuronal synapses |
| title_full | Lytic granule exocytosis at immune synapses: lessons from neuronal synapses |
| title_fullStr | Lytic granule exocytosis at immune synapses: lessons from neuronal synapses |
| title_full_unstemmed | Lytic granule exocytosis at immune synapses: lessons from neuronal synapses |
| title_short | Lytic granule exocytosis at immune synapses: lessons from neuronal synapses |
| title_sort | lytic granule exocytosis at immune synapses lessons from neuronal synapses |
| topic | synapse CD8+ cells cytotoxic T lymphocytes neuron exocytosis endocytosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1177670/full |
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