Fragmentation of Nimotuzumab for Preparation of 125I-F(ab’)2-Nimotuzumab as a Precursor for Preparing 125I-F(ab’)2-Nimotuzumab-NLS Radiopharmaceutical for Cancer Therapy

Fragmentation of Nimotuzumab for Preparation of 125I-F(ab’)2-Nimotuzumab as a Precursor for Preparing 125I-F(ab’)2-Nimotuzumab-NLS Radiopharmaceutical for Cancer Therapy

Nimotuzumab is an anticancer agent which belongs to the inhibitor group of Epidermal Growth Factor Receptor (EGFR). This monoclonal antibody has a relatively high molecular weight which makes slow penetration on tumor cell, as concequence, it is less attractive in imaging kinetics, and potentially e...

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Bibliographic Details
Main Authors: R.D. Haryuni, A. Bahtiar, S. Soenarjo, Y. Harahap, A. Mutalib, M. Ramli, S. Hermanto, C.N. Ardiyatno, V.Y. Susilo, D. Haffid
Format: Article
Language:English
Published: Center for Development of Nuclear Informatics, National Nuclear Energy Agency (BATAN) 2014-04-01
Series:Atom Indonesia
Subjects:
Fragmentation
Radiolabeling
125I-F(ab’)2-nimotuzumab
125I-nimotuzumab
Online Access:http://aij.batan.go.id/index.php/aij/article/view/259

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