Discovery of CNS-Like D3R-Selective Antagonists Using 3D Pharmacophore Guided Virtual Screening

Discovery of CNS-Like D3R-Selective Antagonists Using 3D Pharmacophore Guided Virtual Screening

The dopamine D3 receptor is an important CNS target for the treatment of a variety of neurological diseases. Selective dopamine D3 receptor antagonists modulate the improvement of psychostimulant addiction and relapse. In this study, five and six featured pharmacophore models of D3R antagonists were...

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Bibliographic Details
Main Authors:	June Hyeong Lee, Sung Jin Cho, Mi-hyun Kim
Format:	Article
Language:	English
Published:	MDPI AG 2018-09-01
Series:	Molecules
Subjects:	pharmacophore 3D-QSAR virtual screening D3R selective antagonist molecular docking CNS-like
Online Access:	http://www.mdpi.com/1420-3049/23/10/2452

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