Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran
Abstract Polycyclic aromatic hydrocarbons (PAHs) are persistent toxic substances that have ubiquitous presence in water, air, soil, and sediment environments, posing serious environmental risks. The present study aimed to investigate the concentrations of urinary PAHs and their health effects in ind...
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-12040-8 |
| _version_ | 1811250976654360576 |
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| author | Narges Shamsedini Mansooreh Dehghani Mohammadreza Samaei Aboolfazl Azhdarpoor Mohammad Hoseini Mohammad Fararouei Shayan Bahrany Sareh Roosta |
| author_facet | Narges Shamsedini Mansooreh Dehghani Mohammadreza Samaei Aboolfazl Azhdarpoor Mohammad Hoseini Mohammad Fararouei Shayan Bahrany Sareh Roosta |
| author_sort | Narges Shamsedini |
| collection | DOAJ |
| description | Abstract Polycyclic aromatic hydrocarbons (PAHs) are persistent toxic substances that have ubiquitous presence in water, air, soil, and sediment environments, posing serious environmental risks. The present study aimed to investigate the concentrations of urinary PAHs and their health effects in individuals living near restaurants via a health risk assessment analysis. This cross-sectional study was performed on 57 people living near restaurants and 30 individuals as the control group. Five urinary metabolites of PAHs were monitored. In order to evaluate the effects of the urinary metabolites of PAHs on Malondialdehyde (MDA) concentration, Total Anti-oxidation Capacity (TAC) in urine samples, and C-Reactive Protein (CRP) in serum samples, regression model was used by considering the effects of the possible confounding factors. Non-carcinogenic health risk was calculated, as well. The median concentration of urinary PAHs was 1196.70 and 627.54 ng/g creatinine in the people living near restaurants and the control group, respectively. Among the metabolites, the lowest and highest mean concentrations were related to 9-OHPhe and 1-OHP, respectively in the two study groups. Moreover, PAHs were significantly associated with MDA level and TAC (p < 0.05). Hazard Quotient (HQ) and Hazard Index (HI) were less than 1. Long-term studies are required to determine the actual health effects by identifying the sources of PAHs emission and to find ways to decrease the production of these compounds. |
| first_indexed | 2024-04-12T16:12:46Z |
| format | Article |
| id | doaj.art-86492b4c7d2d411eb8c76b8385dbd304 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T16:12:46Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-86492b4c7d2d411eb8c76b8385dbd3042022-12-22T03:25:51ZengNature PortfolioScientific Reports2045-23222022-05-011211810.1038/s41598-022-12040-8Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, IranNarges Shamsedini0Mansooreh Dehghani1Mohammadreza Samaei2Aboolfazl Azhdarpoor3Mohammad Hoseini4Mohammad Fararouei5Shayan Bahrany6Sareh Roosta7Department of Environmental Health Engineering, School of Health, Student Research Committee, Shiraz University of Medical SciencesResearch Center for Health Sciences, Department of Environmental Health Engineering, School of Health, Shiraz University of Medical SciencesResearch Center for Health Sciences, Department of Environmental Health Engineering, School of Health, Shiraz University of Medical SciencesResearch Center for Health Sciences, Department of Environmental Health Engineering, School of Health, Shiraz University of Medical SciencesResearch Center for Health Sciences, Department of Environmental Health Engineering, School of Health, Shiraz University of Medical SciencesResearch Center for Health Sciences, Department of Environmental Health Engineering, School of Health, Shiraz University of Medical SciencesDepartment of Environmental Health Engineering, School of Health, Student Research Committee, Shiraz University of Medical SciencesShiraz University of Medical SciencesAbstract Polycyclic aromatic hydrocarbons (PAHs) are persistent toxic substances that have ubiquitous presence in water, air, soil, and sediment environments, posing serious environmental risks. The present study aimed to investigate the concentrations of urinary PAHs and their health effects in individuals living near restaurants via a health risk assessment analysis. This cross-sectional study was performed on 57 people living near restaurants and 30 individuals as the control group. Five urinary metabolites of PAHs were monitored. In order to evaluate the effects of the urinary metabolites of PAHs on Malondialdehyde (MDA) concentration, Total Anti-oxidation Capacity (TAC) in urine samples, and C-Reactive Protein (CRP) in serum samples, regression model was used by considering the effects of the possible confounding factors. Non-carcinogenic health risk was calculated, as well. The median concentration of urinary PAHs was 1196.70 and 627.54 ng/g creatinine in the people living near restaurants and the control group, respectively. Among the metabolites, the lowest and highest mean concentrations were related to 9-OHPhe and 1-OHP, respectively in the two study groups. Moreover, PAHs were significantly associated with MDA level and TAC (p < 0.05). Hazard Quotient (HQ) and Hazard Index (HI) were less than 1. Long-term studies are required to determine the actual health effects by identifying the sources of PAHs emission and to find ways to decrease the production of these compounds.https://doi.org/10.1038/s41598-022-12040-8 |
| spellingShingle | Narges Shamsedini Mansooreh Dehghani Mohammadreza Samaei Aboolfazl Azhdarpoor Mohammad Hoseini Mohammad Fararouei Shayan Bahrany Sareh Roosta Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran Scientific Reports |
| title | Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran |
| title_full | Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran |
| title_fullStr | Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran |
| title_full_unstemmed | Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran |
| title_short | Health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants: a cross-sectional study in Shiraz, Iran |
| title_sort | health risk assessment of polycyclic aromatic hydrocarbons in individuals living near restaurants a cross sectional study in shiraz iran |
| url | https://doi.org/10.1038/s41598-022-12040-8 |
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