Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review
Periodontal disease (PD) and obesity are characterized by a dysregulated inflammatory state. Both conditions trigger inflammatory and immune responses with an increase in proinflammatory cytokines such as Interleukin 6 (IL-6) and the release of inflammatory mediators such as C-reactive protein (CRP)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/10/12/225 |
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| author | Julieta Cruz-Ávila Elizabeth Hernández-Pérez Rogelio González-González Ronell Bologna-Molina Nelly Molina-Frechero |
| author_facet | Julieta Cruz-Ávila Elizabeth Hernández-Pérez Rogelio González-González Ronell Bologna-Molina Nelly Molina-Frechero |
| author_sort | Julieta Cruz-Ávila |
| collection | DOAJ |
| description | Periodontal disease (PD) and obesity are characterized by a dysregulated inflammatory state. Both conditions trigger inflammatory and immune responses with an increase in proinflammatory cytokines such as Interleukin 6 (IL-6) and the release of inflammatory mediators such as C-reactive protein (CRP). Individuals with a high body mass index (BMI) present a chronic inflammatory state. The aim of the present study was to perform a systematic review of inflammatory markers (IL-6 and CRP) in obese patients with PD and their possible relationship by analyzing the levels of these markers. A digital literature search was performed in three databases—PubMed, SciElo and Medigraphic—through an advanced search for original articles, employing IL-6 and CRP in obese patients with PD, within a publication period from 2010 to 2021. PRISMA guidelines, the JADAD scale and a qualitative analysis of scientific evidence were performed using the Cochrane collaboration method and the RoB 2 assessment tool. Ten articles were included in this analysis with the variables recorded and associated with subjects with obesity and PD. Of the ten articles included, three analyzed IL-6 and CRP, four analyzed IL-6 and three analyzed CRP. In conclusion, and based on the available evidence, the aforementioned markers of inflammation demonstrate that there is a relationship between PD and obesity. |
| first_indexed | 2024-03-09T17:09:28Z |
| format | Article |
| id | doaj.art-864ad3041184459ca6b01ad1d037ba2d |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-09T17:09:28Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-864ad3041184459ca6b01ad1d037ba2d2023-11-24T14:14:09ZengMDPI AGDentistry Journal2304-67672022-11-01101222510.3390/dj10120225Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic ReviewJulieta Cruz-Ávila0Elizabeth Hernández-Pérez1Rogelio González-González2Ronell Bologna-Molina3Nelly Molina-Frechero4Dental Sciences, Department of Health Care, Universidad Autónoma Metropolitana Xochimilco (UAM-X), Mexico City 04960, MexicoDepartment of Health Sciences, Universidad Autónoma Metropolitana Iztapalapa (UAM-I), Mexico City 09340, MexicoDepartment of Research, School of Dentistry, Juarez University of the Durango State (UJED), Durango 34000, MexicoMolecular Pathology Area, School of Dentistry, University of the Republic (UDELAR), Montevideo 11200, UruguayDepartment of Health Care, Universidad Autónoma Metropolitana Xochimilco (UAM-X), Mexico City 04960, MexicoPeriodontal disease (PD) and obesity are characterized by a dysregulated inflammatory state. Both conditions trigger inflammatory and immune responses with an increase in proinflammatory cytokines such as Interleukin 6 (IL-6) and the release of inflammatory mediators such as C-reactive protein (CRP). Individuals with a high body mass index (BMI) present a chronic inflammatory state. The aim of the present study was to perform a systematic review of inflammatory markers (IL-6 and CRP) in obese patients with PD and their possible relationship by analyzing the levels of these markers. A digital literature search was performed in three databases—PubMed, SciElo and Medigraphic—through an advanced search for original articles, employing IL-6 and CRP in obese patients with PD, within a publication period from 2010 to 2021. PRISMA guidelines, the JADAD scale and a qualitative analysis of scientific evidence were performed using the Cochrane collaboration method and the RoB 2 assessment tool. Ten articles were included in this analysis with the variables recorded and associated with subjects with obesity and PD. Of the ten articles included, three analyzed IL-6 and CRP, four analyzed IL-6 and three analyzed CRP. In conclusion, and based on the available evidence, the aforementioned markers of inflammation demonstrate that there is a relationship between PD and obesity.https://www.mdpi.com/2304-6767/10/12/225IL-6periodontal diseaseobesityC-reactive protein |
| spellingShingle | Julieta Cruz-Ávila Elizabeth Hernández-Pérez Rogelio González-González Ronell Bologna-Molina Nelly Molina-Frechero Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review Dentistry Journal IL-6 periodontal disease obesity C-reactive protein |
| title | Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review |
| title_full | Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review |
| title_fullStr | Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review |
| title_full_unstemmed | Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review |
| title_short | Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review |
| title_sort | periodontal disease in obese patients interleukin 6 and c reactive protein study a systematic review |
| topic | IL-6 periodontal disease obesity C-reactive protein |
| url | https://www.mdpi.com/2304-6767/10/12/225 |
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