An overview of the mechanisms and potential roles of extracellular vesicles in septic shock
Septic shock, a subset of sepsis, is a fatal condition associated with high morbidity and mortality. However, the pathophysiology of septic shock is not fully understood. Moreover, the diagnostic markers employed for identifying septic shock lack optimal sensitivity and specificity. Current treatmen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1324253/full |
| _version_ | 1797346239166021632 |
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| author | Meiling Cao Mingyue Shi Boru Zhou Hongkun Jiang |
| author_facet | Meiling Cao Mingyue Shi Boru Zhou Hongkun Jiang |
| author_sort | Meiling Cao |
| collection | DOAJ |
| description | Septic shock, a subset of sepsis, is a fatal condition associated with high morbidity and mortality. However, the pathophysiology of septic shock is not fully understood. Moreover, the diagnostic markers employed for identifying septic shock lack optimal sensitivity and specificity. Current treatment protocols for septic shock have not been effective in lowering the mortality rate of patients. Most cells exhibit the capability to release extracellular vesicles (EVs), nanoscale vesicles that play a vital role in intercellular communication. In recent years, researchers have investigated the potential role of EVs in the pathogenesis, diagnosis, and treatment of different diseases, such as oncological, neurological, and cardiovascular diseases, as well as diabetes and septic shock. In this article, we present an overview of the inhibitory and facilitative roles that EVs play in the process of septic shock, the potential role of EVs in the diagnosis of septic shock, and the potential therapeutic applications of both native and engineered EVs in the management of septic shock. |
| first_indexed | 2024-03-08T11:29:07Z |
| format | Article |
| id | doaj.art-864c1a5288ed4c4d84fe10078e53d7fc |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T11:29:07Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-864c1a5288ed4c4d84fe10078e53d7fc2024-01-26T04:19:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011410.3389/fimmu.2023.13242531324253An overview of the mechanisms and potential roles of extracellular vesicles in septic shockMeiling Cao0Mingyue Shi1Boru Zhou2Hongkun Jiang3Department of Neonatology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaSeptic shock, a subset of sepsis, is a fatal condition associated with high morbidity and mortality. However, the pathophysiology of septic shock is not fully understood. Moreover, the diagnostic markers employed for identifying septic shock lack optimal sensitivity and specificity. Current treatment protocols for septic shock have not been effective in lowering the mortality rate of patients. Most cells exhibit the capability to release extracellular vesicles (EVs), nanoscale vesicles that play a vital role in intercellular communication. In recent years, researchers have investigated the potential role of EVs in the pathogenesis, diagnosis, and treatment of different diseases, such as oncological, neurological, and cardiovascular diseases, as well as diabetes and septic shock. In this article, we present an overview of the inhibitory and facilitative roles that EVs play in the process of septic shock, the potential role of EVs in the diagnosis of septic shock, and the potential therapeutic applications of both native and engineered EVs in the management of septic shock.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1324253/fulldiagnosisextracellular vesicles (EVs)nanoscale vesiclespathogenesisseptic shocktreatment |
| spellingShingle | Meiling Cao Mingyue Shi Boru Zhou Hongkun Jiang An overview of the mechanisms and potential roles of extracellular vesicles in septic shock Frontiers in Immunology diagnosis extracellular vesicles (EVs) nanoscale vesicles pathogenesis septic shock treatment |
| title | An overview of the mechanisms and potential roles of extracellular vesicles in septic shock |
| title_full | An overview of the mechanisms and potential roles of extracellular vesicles in septic shock |
| title_fullStr | An overview of the mechanisms and potential roles of extracellular vesicles in septic shock |
| title_full_unstemmed | An overview of the mechanisms and potential roles of extracellular vesicles in septic shock |
| title_short | An overview of the mechanisms and potential roles of extracellular vesicles in septic shock |
| title_sort | overview of the mechanisms and potential roles of extracellular vesicles in septic shock |
| topic | diagnosis extracellular vesicles (EVs) nanoscale vesicles pathogenesis septic shock treatment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1324253/full |
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