Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices
Cardiac amyloidosis (CA) is a rare but potentially life-threatening disease in which misfolded proteins accumulate in the cardiac wall tissue. Heart rhythm disorders in CA, including supraventricular arrhythmias, conduction system disturbances, or ventricular arrhythmias, play a major role in CA mor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/8/337 |
| _version_ | 1797584345587777536 |
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| author | Alexandros Briasoulis Christos Kourek Adamantia Papamichail Konstantinos Loritis Dimitrios Bampatsias Evangelos Repasos Andrew Xanthopoulos Elias Tsougos Ioannis Paraskevaidis |
| author_facet | Alexandros Briasoulis Christos Kourek Adamantia Papamichail Konstantinos Loritis Dimitrios Bampatsias Evangelos Repasos Andrew Xanthopoulos Elias Tsougos Ioannis Paraskevaidis |
| author_sort | Alexandros Briasoulis |
| collection | DOAJ |
| description | Cardiac amyloidosis (CA) is a rare but potentially life-threatening disease in which misfolded proteins accumulate in the cardiac wall tissue. Heart rhythm disorders in CA, including supraventricular arrhythmias, conduction system disturbances, or ventricular arrhythmias, play a major role in CA morbidity and mortality, and thus require supplementary management. Among them, AF is the most frequent arrhythmia during CA hospitalizations and is associated with significantly higher mortality, while ventricular arrhythmias are also common and are usually associated with poor prognosis. Early diagnosis of potential arrythmias could be performed through ECG, Holter monitoring, and/or electrophysiology study. Clinical management of these patients is quite significant, and it usually includes initiation of amiodarone and/or digoxin in patients with AF, potential electrical cardioversion, or ablation in specific patients with indication, as well as initiation of anticoagulants in all patients, independent of AF and CHADS-VASc score, for potential intracardiac thrombus. Moreover, identification of patients with conduction disorders that could benefit from prophylactic pacemaker implantation and/or CRT as well as identification of patients with life-threatening ventricular arrythmias that could benefit from ICD could both increase the survival rates of these patients and improve their quality of life. |
| first_indexed | 2024-03-10T23:51:33Z |
| format | Article |
| id | doaj.art-864d65b623674d668f8d24a91e3252a0 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T23:51:33Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-864d65b623674d668f8d24a91e3252a02023-11-19T01:38:16ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-08-0110833710.3390/jcdd10080337Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and DevicesAlexandros Briasoulis0Christos Kourek1Adamantia Papamichail2Konstantinos Loritis3Dimitrios Bampatsias4Evangelos Repasos5Andrew Xanthopoulos6Elias Tsougos7Ioannis Paraskevaidis8Medical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, GreeceMedical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, GreeceMedical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, GreeceMedical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, GreeceMedical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, GreeceMedical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, GreeceDepartment of Cardiology, University Hospital of Larissa, 41110 Larissa, GreeceDepartment of Cardiology, Hygeia Hospital, 15123 Athens, GreeceMedical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, GreeceCardiac amyloidosis (CA) is a rare but potentially life-threatening disease in which misfolded proteins accumulate in the cardiac wall tissue. Heart rhythm disorders in CA, including supraventricular arrhythmias, conduction system disturbances, or ventricular arrhythmias, play a major role in CA morbidity and mortality, and thus require supplementary management. Among them, AF is the most frequent arrhythmia during CA hospitalizations and is associated with significantly higher mortality, while ventricular arrhythmias are also common and are usually associated with poor prognosis. Early diagnosis of potential arrythmias could be performed through ECG, Holter monitoring, and/or electrophysiology study. Clinical management of these patients is quite significant, and it usually includes initiation of amiodarone and/or digoxin in patients with AF, potential electrical cardioversion, or ablation in specific patients with indication, as well as initiation of anticoagulants in all patients, independent of AF and CHADS-VASc score, for potential intracardiac thrombus. Moreover, identification of patients with conduction disorders that could benefit from prophylactic pacemaker implantation and/or CRT as well as identification of patients with life-threatening ventricular arrythmias that could benefit from ICD could both increase the survival rates of these patients and improve their quality of life.https://www.mdpi.com/2308-3425/10/8/337cardiac amyloidosisarrhythmiasatrial fibrillationventricular arrhythmiasdevicesclinical management |
| spellingShingle | Alexandros Briasoulis Christos Kourek Adamantia Papamichail Konstantinos Loritis Dimitrios Bampatsias Evangelos Repasos Andrew Xanthopoulos Elias Tsougos Ioannis Paraskevaidis Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices Journal of Cardiovascular Development and Disease cardiac amyloidosis arrhythmias atrial fibrillation ventricular arrhythmias devices clinical management |
| title | Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices |
| title_full | Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices |
| title_fullStr | Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices |
| title_full_unstemmed | Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices |
| title_short | Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices |
| title_sort | arrhythmias in patients with cardiac amyloidosis a comprehensive review on clinical management and devices |
| topic | cardiac amyloidosis arrhythmias atrial fibrillation ventricular arrhythmias devices clinical management |
| url | https://www.mdpi.com/2308-3425/10/8/337 |
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