Symptomatic ovarian involvement as the initial presentation of primary mediastinal large b-cell lymphoma
Primary mediastinal large B- cell lymphoma (PMLBCL) is a mature aggressive B-cell lymphoma which affects mainly young and middle-aged women. The majority of patients present with bulky mediastinal lymphadenopathy. Extranodal involvement is a rare phenomenon at disease presentation. Herein, we descri...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578922000686 |
| _version_ | 1828344709893849088 |
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| author | Alexia Piperidou Ioannis Drandakis Maria-Aikaterini Lefaki Eleftheria Lakiotaki Helen Plyta Georgia Sypsa Maria Tsolakou-Dalekou Maria Androulaki Fotios Panitsas Eleni Plata Penelope Korkolopoulou Theodoros P. Vassilakopoulos |
| author_facet | Alexia Piperidou Ioannis Drandakis Maria-Aikaterini Lefaki Eleftheria Lakiotaki Helen Plyta Georgia Sypsa Maria Tsolakou-Dalekou Maria Androulaki Fotios Panitsas Eleni Plata Penelope Korkolopoulou Theodoros P. Vassilakopoulos |
| author_sort | Alexia Piperidou |
| collection | DOAJ |
| description | Primary mediastinal large B- cell lymphoma (PMLBCL) is a mature aggressive B-cell lymphoma which affects mainly young and middle-aged women. The majority of patients present with bulky mediastinal lymphadenopathy. Extranodal involvement is a rare phenomenon at disease presentation. Herein, we describe a case of a young female with PMLBCL presenting with symptomatic, bulky ovarian involvement. The 23-year old patient presented at the Emergency Department with abdominal pain. The chest X-ray film revealed a mediastinal mass and CT scan revealed a large pelvic mass, possibly involving the ovaries. Due to the development of signs of acute abdomen, she was urgently transferred to the operation room where surgical resection of the right ovary and the adjacent mass was performed. The histological examination of the resected material revealed proliferation of PMLBCL cells. This is the first report in the scientific literature describing symptomatic ovarian mass as the initial mode of presentation of PMLBCL. |
| first_indexed | 2024-04-14T00:01:23Z |
| format | Article |
| id | doaj.art-864e38dba35f4006ac806632496204c1 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-04-14T00:01:23Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-864e38dba35f4006ac806632496204c12022-12-22T02:23:41ZengElsevierGynecologic Oncology Reports2352-57892022-06-0141100988Symptomatic ovarian involvement as the initial presentation of primary mediastinal large b-cell lymphomaAlexia Piperidou0Ioannis Drandakis1Maria-Aikaterini Lefaki2Eleftheria Lakiotaki3Helen Plyta4Georgia Sypsa5Maria Tsolakou-Dalekou6Maria Androulaki7Fotios Panitsas8Eleni Plata9Penelope Korkolopoulou10Theodoros P. Vassilakopoulos11Department of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, GreeceDepartment of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, GreeceDepartment of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, GreeceDepartment of Gynecology and Obstetrics, Kalamata General Hospital, GreeceDepartment of Radiology, Laikon General Hospital, Athens 11527, GreeceThalassemia Unit, Kalamata General Hospital, GreeceDepartment of Gynecology and Obstetrics, Kalamata General Hospital, GreeceDepartment of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, GreeceDepartment of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, GreeceDepartment of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, Greece; Corresponding author at: Department of Haematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, Greece.Primary mediastinal large B- cell lymphoma (PMLBCL) is a mature aggressive B-cell lymphoma which affects mainly young and middle-aged women. The majority of patients present with bulky mediastinal lymphadenopathy. Extranodal involvement is a rare phenomenon at disease presentation. Herein, we describe a case of a young female with PMLBCL presenting with symptomatic, bulky ovarian involvement. The 23-year old patient presented at the Emergency Department with abdominal pain. The chest X-ray film revealed a mediastinal mass and CT scan revealed a large pelvic mass, possibly involving the ovaries. Due to the development of signs of acute abdomen, she was urgently transferred to the operation room where surgical resection of the right ovary and the adjacent mass was performed. The histological examination of the resected material revealed proliferation of PMLBCL cells. This is the first report in the scientific literature describing symptomatic ovarian mass as the initial mode of presentation of PMLBCL.http://www.sciencedirect.com/science/article/pii/S2352578922000686Acute abdomenExtranodalLymphomaOvaryPMLBCL |
| spellingShingle | Alexia Piperidou Ioannis Drandakis Maria-Aikaterini Lefaki Eleftheria Lakiotaki Helen Plyta Georgia Sypsa Maria Tsolakou-Dalekou Maria Androulaki Fotios Panitsas Eleni Plata Penelope Korkolopoulou Theodoros P. Vassilakopoulos Symptomatic ovarian involvement as the initial presentation of primary mediastinal large b-cell lymphoma Gynecologic Oncology Reports Acute abdomen Extranodal Lymphoma Ovary PMLBCL |
| title | Symptomatic ovarian involvement as the initial presentation of primary mediastinal large b-cell lymphoma |
| title_full | Symptomatic ovarian involvement as the initial presentation of primary mediastinal large b-cell lymphoma |
| title_fullStr | Symptomatic ovarian involvement as the initial presentation of primary mediastinal large b-cell lymphoma |
| title_full_unstemmed | Symptomatic ovarian involvement as the initial presentation of primary mediastinal large b-cell lymphoma |
| title_short | Symptomatic ovarian involvement as the initial presentation of primary mediastinal large b-cell lymphoma |
| title_sort | symptomatic ovarian involvement as the initial presentation of primary mediastinal large b cell lymphoma |
| topic | Acute abdomen Extranodal Lymphoma Ovary PMLBCL |
| url | http://www.sciencedirect.com/science/article/pii/S2352578922000686 |
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