First‐in‐human clinical trial of allogeneic, platelet‐derived extracellular vesicles as a potential therapeutic for delayed wound healing

First‐in‐human clinical trial of allogeneic, platelet‐derived extracellular vesicles as a potential therapeutic for delayed wound healing

Abstract The release of growth factors, cytokines and extracellular matrix modifiers by activated platelets is an important step in the process of healthy wound healing. Extracellular vesicles (EVs) released by activated platelets carry this bioactive cargo in an enriched form, and may therefore rep...

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Bibliographic Details
Main Authors: Jancy Johnson, Sam Q. K. Law, Mozhgan Shojaee, Alex S. Hall, Sadman Bhuiyan, Melissa B. L. Lim, Anabel Silva, Karmen J. W. Kong, Melanie Schoppet, Chantelle Blyth, Hansi N. Ranasinghe, Nenad Sejic, Mun Joo Chuei, Owen C. Tatford, Anna Cifuentes‐Rius, Patrick F. James, Angus Tester, Ian Dixon, Gregor Lichtfuss
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Journal of Extracellular Vesicles
Subjects:
extracellular vesicles
first‐in‐human platelet EV therapy
platelet EVs
wound healing
Online Access:https://doi.org/10.1002/jev2.12332

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