ETIOPATHOGENESIS OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILE
Clostridium (C.) difficile is a typical representative of the genus Clostridium. After colonization of the intestinal tract, toxigenic C. difficile strains are capable to produce two exotoxins, enterotoxin (toxin A) and cytotoxin (toxin B), which cause diarrhea and colitis. Toxin A binds to specific...
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| Format: | Article |
| Language: | English |
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University in Nis, Faculty of Medicine
2015-03-01
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| Series: | Acta Medica Medianae |
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| Online Access: | http://publisher.medfak.ni.ac.rs/2015-html/1-broj/P.Stojanovic%20ETIOPATHOGENESIS%20OF.pdf |
| _version_ | 1823988088254234624 |
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| author | Predrag Stojanović |
| author_facet | Predrag Stojanović |
| author_sort | Predrag Stojanović |
| collection | DOAJ |
| description | Clostridium (C.) difficile is a typical representative of the genus Clostridium. After colonization of the intestinal tract, toxigenic C. difficile strains are capable to produce two exotoxins, enterotoxin (toxin A) and cytotoxin (toxin B), which cause diarrhea and colitis. Toxin A binds to specific carbohydrate receptors on the surface of intestinal cells and this is the beginning of damages in the intestinal tract which include destruction of the villi epithelium, limiting membrane, intercellular connections (zonula occludens) and surface of the mucosa. If only toxin B is injected into intestinal cells, it does not cause damage nor increased fluids secretion. Probably, the reason for this is the inability of the toxin to bind to the cell membrane receptor in the intestinal tract under normal physiological conditions. Toxigenic strains of C. difficile can be found in the intestines of healthy people, without any symptoms or clinical signs (asymptomatic colonization). However, in people with risk factors, they can cause diarrhea of varying severity and life-threatening pseudomembranous colitis. These diseases are known as C. difficile associated disease - CDAD. |
| first_indexed | 2024-12-18T13:38:05Z |
| format | Article |
| id | doaj.art-8654288c62994415963e881a5275b59b |
| institution | Directory Open Access Journal |
| issn | 0365-4478 1821-2794 |
| language | English |
| last_indexed | 2024-12-18T13:38:05Z |
| publishDate | 2015-03-01 |
| publisher | University in Nis, Faculty of Medicine |
| record_format | Article |
| series | Acta Medica Medianae |
| spelling | doaj.art-8654288c62994415963e881a5275b59b2022-12-21T21:05:56ZengUniversity in Nis, Faculty of MedicineActa Medica Medianae0365-44781821-27942015-03-01541606510.5633/amm.2015.0110 ETIOPATHOGENESIS OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILEPredrag Stojanović0University of Niš, Faculty of Medicine, Public Health Institute Niš, SerbiaClostridium (C.) difficile is a typical representative of the genus Clostridium. After colonization of the intestinal tract, toxigenic C. difficile strains are capable to produce two exotoxins, enterotoxin (toxin A) and cytotoxin (toxin B), which cause diarrhea and colitis. Toxin A binds to specific carbohydrate receptors on the surface of intestinal cells and this is the beginning of damages in the intestinal tract which include destruction of the villi epithelium, limiting membrane, intercellular connections (zonula occludens) and surface of the mucosa. If only toxin B is injected into intestinal cells, it does not cause damage nor increased fluids secretion. Probably, the reason for this is the inability of the toxin to bind to the cell membrane receptor in the intestinal tract under normal physiological conditions. Toxigenic strains of C. difficile can be found in the intestines of healthy people, without any symptoms or clinical signs (asymptomatic colonization). However, in people with risk factors, they can cause diarrhea of varying severity and life-threatening pseudomembranous colitis. These diseases are known as C. difficile associated disease - CDAD.http://publisher.medfak.ni.ac.rs/2015-html/1-broj/P.Stojanovic%20ETIOPATHOGENESIS%20OF.pdfClostridium difficilediarrheapathogenesis |
| spellingShingle | Predrag Stojanović ETIOPATHOGENESIS OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILE Acta Medica Medianae Clostridium difficile diarrhea pathogenesis |
| title | ETIOPATHOGENESIS OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILE |
| title_full | ETIOPATHOGENESIS OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILE |
| title_fullStr | ETIOPATHOGENESIS OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILE |
| title_full_unstemmed | ETIOPATHOGENESIS OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILE |
| title_short | ETIOPATHOGENESIS OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILE |
| title_sort | etiopathogenesis of diseases caused by clostridium difficile |
| topic | Clostridium difficile diarrhea pathogenesis |
| url | http://publisher.medfak.ni.ac.rs/2015-html/1-broj/P.Stojanovic%20ETIOPATHOGENESIS%20OF.pdf |
| work_keys_str_mv | AT predragstojanovic etiopathogenesisofdiseasescausedbyclostridiumdifficile |