Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing
<p>Abstract</p> <p>Background</p> <p>Regenerative wound repair is a goal of modern medicine. This is important not only for the local repair but also for its beneficial effect to systemic physiological processes. When wounds become chronic, individuals are susceptible t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-01-01
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| Series: | BMC Cell Biology |
| Online Access: | http://www.biomedcentral.com/1471-2121/10/1 |
| _version_ | 1818665616325738496 |
|---|---|
| author | Yao Min Petreaca Melissa Liu Yan Martins-Green Manuela |
| author_facet | Yao Min Petreaca Melissa Liu Yan Martins-Green Manuela |
| author_sort | Yao Min |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Regenerative wound repair is a goal of modern medicine. This is important not only for the local repair but also for its beneficial effect to systemic physiological processes. When wounds become chronic, individuals are susceptible to generalized inflammatory cascades that can affect many organs and even lead to death. Skin is the most commonly injured tissue, and its proper repair is important for reestablishment of its barrier function.</p> <p>Results</p> <p>We show here that insulin, when topically applied to skin excision wounds, accelerates re-epithelialization and stimulates "maturation" of the healing tissue. These effects are dependent on the insulin receptor but independent of EGF/EGF-R; PI3K-Akt-Rac1 signaling pathways are critically involved, and healing is α3 and LN332-dependent.</p> <p>Conclusion</p> <p>Insulin has great potential for the treatments of chronic wounds in which re-epthelialization is impaired. Understanding of the pathways induced by insulin is important for the development of analog molecules that function strictly in healing. Because of its long history of safe use in humans for decades, this protein may prove to be a powerful therapy without major adverse effects.</p> |
| first_indexed | 2024-12-17T05:51:28Z |
| format | Article |
| id | doaj.art-865779e6745f47a08ca3c6f460846d57 |
| institution | Directory Open Access Journal |
| issn | 1471-2121 |
| language | English |
| last_indexed | 2024-12-17T05:51:28Z |
| publishDate | 2009-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cell Biology |
| spelling | doaj.art-865779e6745f47a08ca3c6f460846d572022-12-21T22:01:08ZengBMCBMC Cell Biology1471-21212009-01-01101110.1186/1471-2121-10-1Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healingYao MinPetreaca MelissaLiu YanMartins-Green Manuela<p>Abstract</p> <p>Background</p> <p>Regenerative wound repair is a goal of modern medicine. This is important not only for the local repair but also for its beneficial effect to systemic physiological processes. When wounds become chronic, individuals are susceptible to generalized inflammatory cascades that can affect many organs and even lead to death. Skin is the most commonly injured tissue, and its proper repair is important for reestablishment of its barrier function.</p> <p>Results</p> <p>We show here that insulin, when topically applied to skin excision wounds, accelerates re-epithelialization and stimulates "maturation" of the healing tissue. These effects are dependent on the insulin receptor but independent of EGF/EGF-R; PI3K-Akt-Rac1 signaling pathways are critically involved, and healing is α3 and LN332-dependent.</p> <p>Conclusion</p> <p>Insulin has great potential for the treatments of chronic wounds in which re-epthelialization is impaired. Understanding of the pathways induced by insulin is important for the development of analog molecules that function strictly in healing. Because of its long history of safe use in humans for decades, this protein may prove to be a powerful therapy without major adverse effects.</p>http://www.biomedcentral.com/1471-2121/10/1 |
| spellingShingle | Yao Min Petreaca Melissa Liu Yan Martins-Green Manuela Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing BMC Cell Biology |
| title | Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing |
| title_full | Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing |
| title_fullStr | Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing |
| title_full_unstemmed | Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing |
| title_short | Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing |
| title_sort | cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing |
| url | http://www.biomedcentral.com/1471-2121/10/1 |
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