Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts.
Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is nec...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4598150?pdf=render |
| _version_ | 1818981667924082688 |
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| author | Chun-Lin Chen Ying-Pin Chen Ming-Wei Lin Yaw-Bin Huang Fang-Rong Chang Tsai-Hui Duh Deng-Chyang Wu Wei-Chiang Wu Yu-Chen Kao Pei-Hua Yang |
| author_facet | Chun-Lin Chen Ying-Pin Chen Ming-Wei Lin Yaw-Bin Huang Fang-Rong Chang Tsai-Hui Duh Deng-Chyang Wu Wei-Chiang Wu Yu-Chen Kao Pei-Hua Yang |
| author_sort | Chun-Lin Chen |
| collection | DOAJ |
| description | Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors. |
| first_indexed | 2024-12-20T17:34:58Z |
| format | Article |
| id | doaj.art-86588a0090844f5ea3aa33cb50d4ff74 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T17:34:58Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-86588a0090844f5ea3aa33cb50d4ff742022-12-21T19:31:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014024910.1371/journal.pone.0140249Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts.Chun-Lin ChenYing-Pin ChenMing-Wei LinYaw-Bin HuangFang-Rong ChangTsai-Hui DuhDeng-Chyang WuWei-Chiang WuYu-Chen KaoPei-Hua YangTransforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors.http://europepmc.org/articles/PMC4598150?pdf=render |
| spellingShingle | Chun-Lin Chen Ying-Pin Chen Ming-Wei Lin Yaw-Bin Huang Fang-Rong Chang Tsai-Hui Duh Deng-Chyang Wu Wei-Chiang Wu Yu-Chen Kao Pei-Hua Yang Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. PLoS ONE |
| title | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. |
| title_full | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. |
| title_fullStr | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. |
| title_full_unstemmed | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. |
| title_short | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. |
| title_sort | euphol from euphorbia tirucalli negatively modulates tgf β responsiveness via tgf β receptor segregation inside membrane rafts |
| url | http://europepmc.org/articles/PMC4598150?pdf=render |
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