Hereditary Colorectal Cancer Syndromes: Molecular Genetics and Precision Medicine
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Hereditary CRC syndromes account for approximately 5–10% of all CRC, with a lifetime risk of CRC that approaches 50–80% in the absence of endoscopic or surgical treatment. Hereditary CRC syndromes can be phenotypically di...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/12/3207 |
| _version_ | 1827641690316341248 |
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| author | Liuxiang Chen Liansong Ye Bing Hu |
| author_facet | Liuxiang Chen Liansong Ye Bing Hu |
| author_sort | Liuxiang Chen |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Hereditary CRC syndromes account for approximately 5–10% of all CRC, with a lifetime risk of CRC that approaches 50–80% in the absence of endoscopic or surgical treatment. Hereditary CRC syndromes can be phenotypically divided into polyposis and non-polyposis syndrome, mainly according to the conditions of polyps. The typical representatives are familial adenomatous polyposis (FAP) and Lynch syndromes (LS), respectively. Over the past few decades, molecular genetics enhanced the discovery of cancer-predisposing genes and revolutionized the field of clinical oncology. Hereditary CRC syndromes have been a key part of this effort, with data showing that pathogenic variants are present in up to 10% of cases. Molecular phenotypes of tumors can not only help identify individuals with genetic susceptibility to CRC but also guide the precision prevention and treatment for the development of CRC. This review emphasizes the molecular basis and prevention strategies for hereditary CRC syndromes. |
| first_indexed | 2024-03-09T17:18:21Z |
| format | Article |
| id | doaj.art-8658d91518964b4cbfd8301de9637489 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:18:21Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-8658d91518964b4cbfd8301de96374892023-11-24T13:28:42ZengMDPI AGBiomedicines2227-90592022-12-011012320710.3390/biomedicines10123207Hereditary Colorectal Cancer Syndromes: Molecular Genetics and Precision MedicineLiuxiang Chen0Liansong Ye1Bing Hu2Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, ChinaColorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Hereditary CRC syndromes account for approximately 5–10% of all CRC, with a lifetime risk of CRC that approaches 50–80% in the absence of endoscopic or surgical treatment. Hereditary CRC syndromes can be phenotypically divided into polyposis and non-polyposis syndrome, mainly according to the conditions of polyps. The typical representatives are familial adenomatous polyposis (FAP) and Lynch syndromes (LS), respectively. Over the past few decades, molecular genetics enhanced the discovery of cancer-predisposing genes and revolutionized the field of clinical oncology. Hereditary CRC syndromes have been a key part of this effort, with data showing that pathogenic variants are present in up to 10% of cases. Molecular phenotypes of tumors can not only help identify individuals with genetic susceptibility to CRC but also guide the precision prevention and treatment for the development of CRC. This review emphasizes the molecular basis and prevention strategies for hereditary CRC syndromes.https://www.mdpi.com/2227-9059/10/12/3207hereditary colorectal cancer syndromespredisposing genesprevention strategies |
| spellingShingle | Liuxiang Chen Liansong Ye Bing Hu Hereditary Colorectal Cancer Syndromes: Molecular Genetics and Precision Medicine Biomedicines hereditary colorectal cancer syndromes predisposing genes prevention strategies |
| title | Hereditary Colorectal Cancer Syndromes: Molecular Genetics and Precision Medicine |
| title_full | Hereditary Colorectal Cancer Syndromes: Molecular Genetics and Precision Medicine |
| title_fullStr | Hereditary Colorectal Cancer Syndromes: Molecular Genetics and Precision Medicine |
| title_full_unstemmed | Hereditary Colorectal Cancer Syndromes: Molecular Genetics and Precision Medicine |
| title_short | Hereditary Colorectal Cancer Syndromes: Molecular Genetics and Precision Medicine |
| title_sort | hereditary colorectal cancer syndromes molecular genetics and precision medicine |
| topic | hereditary colorectal cancer syndromes predisposing genes prevention strategies |
| url | https://www.mdpi.com/2227-9059/10/12/3207 |
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