Research advance on ubiquitin-specific protease 14 as novel carcinogenesis biomarker
Hazardous environmental factors as well as occupational factors can lead to elevated incidence of diseases including tumors, and specific molecular biomarkers are needed to guide the diagnosis and treatment of diseases. In recent years, ubiquitin-specific protease 14 (USP14) has gradually attracted...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Committee of Journal of Environmental and Occupational Medicine
2023-06-01
|
| Series: | 环境与职业医学 |
| Subjects: | |
| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM23001 |
| _version_ | 1797789294726742016 |
|---|---|
| author | Changlong ZHOU Gege LI Lu WANG Hongmei CUI |
| author_facet | Changlong ZHOU Gege LI Lu WANG Hongmei CUI |
| author_sort | Changlong ZHOU |
| collection | DOAJ |
| description | Hazardous environmental factors as well as occupational factors can lead to elevated incidence of diseases including tumors, and specific molecular biomarkers are needed to guide the diagnosis and treatment of diseases. In recent years, ubiquitin-specific protease 14 (USP14) has gradually attracted the attention of researchers. USP14 is widely expressed in various organs of human body and regulates the stability and degradation of important proteins in various signaling pathways. Studies have shown that its abnormal expression is highly correlated with tumors, neurodegenerative diseases, autophagy, immune response, and viral infections, and is involved in the regulation of various classic signaling pathways. It has been shown to play a key role in the development of various human diseases and can be used as a diagnostic and prognostic molecular biomarker and therapeutic target in the development of tumors. This paper reviewed the current status of research on the structure and regulation of USP14 and its function in physiological and pathological processes, with the aim of providing a reference for research on diseases or injuries caused by environmental and occupational factors. |
| first_indexed | 2024-03-13T01:48:34Z |
| format | Article |
| id | doaj.art-865de97321344491bd1ddbf6719785d7 |
| institution | Directory Open Access Journal |
| issn | 2095-9982 |
| language | English |
| last_indexed | 2024-03-13T01:48:34Z |
| publishDate | 2023-06-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj.art-865de97321344491bd1ddbf6719785d72023-07-03T02:07:29ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822023-06-0140672272710.11836/JEOM2300123001Research advance on ubiquitin-specific protease 14 as novel carcinogenesis biomarkerChanglong ZHOU0Gege LI1Lu WANG2Hongmei CUI3Institute of Toxicology, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, ChinaInstitute of Toxicology, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, ChinaDepartment of Nuclear Medicine, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, ChinaInstitute of Toxicology, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, ChinaHazardous environmental factors as well as occupational factors can lead to elevated incidence of diseases including tumors, and specific molecular biomarkers are needed to guide the diagnosis and treatment of diseases. In recent years, ubiquitin-specific protease 14 (USP14) has gradually attracted the attention of researchers. USP14 is widely expressed in various organs of human body and regulates the stability and degradation of important proteins in various signaling pathways. Studies have shown that its abnormal expression is highly correlated with tumors, neurodegenerative diseases, autophagy, immune response, and viral infections, and is involved in the regulation of various classic signaling pathways. It has been shown to play a key role in the development of various human diseases and can be used as a diagnostic and prognostic molecular biomarker and therapeutic target in the development of tumors. This paper reviewed the current status of research on the structure and regulation of USP14 and its function in physiological and pathological processes, with the aim of providing a reference for research on diseases or injuries caused by environmental and occupational factors.http://www.jeom.org/article/cn/10.11836/JEOM23001ubiquitin-specific protease 14carcinogenesis molecular biomarkertumor therapysignaling pathwaytargeted drug |
| spellingShingle | Changlong ZHOU Gege LI Lu WANG Hongmei CUI Research advance on ubiquitin-specific protease 14 as novel carcinogenesis biomarker 环境与职业医学 ubiquitin-specific protease 14 carcinogenesis molecular biomarker tumor therapy signaling pathway targeted drug |
| title | Research advance on ubiquitin-specific protease 14 as novel carcinogenesis biomarker |
| title_full | Research advance on ubiquitin-specific protease 14 as novel carcinogenesis biomarker |
| title_fullStr | Research advance on ubiquitin-specific protease 14 as novel carcinogenesis biomarker |
| title_full_unstemmed | Research advance on ubiquitin-specific protease 14 as novel carcinogenesis biomarker |
| title_short | Research advance on ubiquitin-specific protease 14 as novel carcinogenesis biomarker |
| title_sort | research advance on ubiquitin specific protease 14 as novel carcinogenesis biomarker |
| topic | ubiquitin-specific protease 14 carcinogenesis molecular biomarker tumor therapy signaling pathway targeted drug |
| url | http://www.jeom.org/article/cn/10.11836/JEOM23001 |
| work_keys_str_mv | AT changlongzhou researchadvanceonubiquitinspecificprotease14asnovelcarcinogenesisbiomarker AT gegeli researchadvanceonubiquitinspecificprotease14asnovelcarcinogenesisbiomarker AT luwang researchadvanceonubiquitinspecificprotease14asnovelcarcinogenesisbiomarker AT hongmeicui researchadvanceonubiquitinspecificprotease14asnovelcarcinogenesisbiomarker |