Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammation
Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs that links innate and adaptive immunity. They sense viral and bacterial pathogens and release high levels of Type I interferons (IFN-I) in response to infection. pDCs were shown to contribute to inflammatory responses in the steady...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00279/full |
| _version_ | 1818128822941253632 |
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| author | Dimitry A Chistiakov Alexander N Orekhov Igor A Sobenin Yuri V Bobryshev |
| author_facet | Dimitry A Chistiakov Alexander N Orekhov Igor A Sobenin Yuri V Bobryshev |
| author_sort | Dimitry A Chistiakov |
| collection | DOAJ |
| description | Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs that links innate and adaptive immunity. They sense viral and bacterial pathogens and release high levels of Type I interferons (IFN-I) in response to infection. pDCs were shown to contribute to inflammatory responses in the steady state and in pathology. In atherosclerosis, pDCs are involved in priming vascular inflammation and atherogenesis through production of IFN-I and chemokines that attract inflammatory cells to inflamed sites. pDCs also contribute to the proinflammatory activation of effector T cells, cytotoxic T cells, and conventional DCs. However, tolerogenic populations of pDCs are found that suppress atherosclerosis-associated inflammation through down-regulation of function and proliferation of proinflammatory T cell subsets and induction of regulatory T cells with potent immunomodulatory properties. Notably, atheroprotective tolerogenic DCs could be induced by certain self-antigens or bacterial antigens that suggests for great therapeutic potential of these DCs for development of DC-based anti-atherogenic vaccines. |
| first_indexed | 2024-12-11T07:39:22Z |
| format | Article |
| id | doaj.art-865e55d5a820406cace452e545953e4c |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T07:39:22Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-865e55d5a820406cace452e545953e4c2022-12-22T01:15:37ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-07-01510.3389/fphys.2014.00279103976Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammationDimitry A Chistiakov0Alexander N Orekhov1Igor A Sobenin2Yuri V Bobryshev3Pirogov Russian State Medical UniversityInstitute of General Pathology and PathophysiologyInstitute of General Pathology and PathophysiologyUniversity of New South Wales and University of Western SydneyPlasmacytoid dendritic cells (pDCs) are a specialized subset of DCs that links innate and adaptive immunity. They sense viral and bacterial pathogens and release high levels of Type I interferons (IFN-I) in response to infection. pDCs were shown to contribute to inflammatory responses in the steady state and in pathology. In atherosclerosis, pDCs are involved in priming vascular inflammation and atherogenesis through production of IFN-I and chemokines that attract inflammatory cells to inflamed sites. pDCs also contribute to the proinflammatory activation of effector T cells, cytotoxic T cells, and conventional DCs. However, tolerogenic populations of pDCs are found that suppress atherosclerosis-associated inflammation through down-regulation of function and proliferation of proinflammatory T cell subsets and induction of regulatory T cells with potent immunomodulatory properties. Notably, atheroprotective tolerogenic DCs could be induced by certain self-antigens or bacterial antigens that suggests for great therapeutic potential of these DCs for development of DC-based anti-atherogenic vaccines.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00279/fullAtherosclerosisInflammationdendritic celltoleranceplasmacytoid dendritic cells |
| spellingShingle | Dimitry A Chistiakov Alexander N Orekhov Igor A Sobenin Yuri V Bobryshev Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammation Frontiers in Physiology Atherosclerosis Inflammation dendritic cell tolerance plasmacytoid dendritic cells |
| title | Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammation |
| title_full | Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammation |
| title_fullStr | Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammation |
| title_full_unstemmed | Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammation |
| title_short | Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammation |
| title_sort | plasmacytoid dendritic cells development functions and role in atherosclerotic inflammation |
| topic | Atherosclerosis Inflammation dendritic cell tolerance plasmacytoid dendritic cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00279/full |
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