The Paracaspase MALT1 in Cancer

Almost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified as relying on MALT1 to induce NF-κB activation. In...

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Main Authors: Beatriz Gomez Solsona, Anja Schmitt, Klaus Schulze-Osthoff, Stephan Hailfinger
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomedicines
Subjects:
Online Access:https://www.mdpi.com/2227-9059/10/2/344
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author Beatriz Gomez Solsona
Anja Schmitt
Klaus Schulze-Osthoff
Stephan Hailfinger
author_facet Beatriz Gomez Solsona
Anja Schmitt
Klaus Schulze-Osthoff
Stephan Hailfinger
author_sort Beatriz Gomez Solsona
collection DOAJ
description Almost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified as relying on MALT1 to induce NF-κB activation. In various hematological malignancies and solid tumors, MALT1 is constitutively activated and drives chronic NF-κB target gene expression. Deregulated MALT1 activity in cancer thus promotes tumor cell survival, proliferation, and metastasis. Since the molecular function of MALT1 partially requires its protease activity, pharmacological targeting of MALT1 may represent a promising anti-cancer strategy. Here, we review the molecular features of MALT1 activation and function as well as the therapeutic potential of MALT1 inhibition in hematological malignancies and solid tumors.
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spelling doaj.art-866060f0158b4346aedcc7135c945fc32023-11-23T18:54:08ZengMDPI AGBiomedicines2227-90592022-02-0110234410.3390/biomedicines10020344The Paracaspase MALT1 in CancerBeatriz Gomez Solsona0Anja Schmitt1Klaus Schulze-Osthoff2Stephan Hailfinger3Interfaculty Institute of Biochemistry, University of Tuebingen, 72076 Tuebingen, GermanyDepartment of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, 48149 Muenster, GermanyInterfaculty Institute of Biochemistry, University of Tuebingen, 72076 Tuebingen, GermanyDepartment of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, 48149 Muenster, GermanyAlmost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified as relying on MALT1 to induce NF-κB activation. In various hematological malignancies and solid tumors, MALT1 is constitutively activated and drives chronic NF-κB target gene expression. Deregulated MALT1 activity in cancer thus promotes tumor cell survival, proliferation, and metastasis. Since the molecular function of MALT1 partially requires its protease activity, pharmacological targeting of MALT1 may represent a promising anti-cancer strategy. Here, we review the molecular features of MALT1 activation and function as well as the therapeutic potential of MALT1 inhibition in hematological malignancies and solid tumors.https://www.mdpi.com/2227-9059/10/2/344MALT1BCL10CARD11CARD10CBM complexNF-κB
spellingShingle Beatriz Gomez Solsona
Anja Schmitt
Klaus Schulze-Osthoff
Stephan Hailfinger
The Paracaspase MALT1 in Cancer
Biomedicines
MALT1
BCL10
CARD11
CARD10
CBM complex
NF-κB
title The Paracaspase MALT1 in Cancer
title_full The Paracaspase MALT1 in Cancer
title_fullStr The Paracaspase MALT1 in Cancer
title_full_unstemmed The Paracaspase MALT1 in Cancer
title_short The Paracaspase MALT1 in Cancer
title_sort paracaspase malt1 in cancer
topic MALT1
BCL10
CARD11
CARD10
CBM complex
NF-κB
url https://www.mdpi.com/2227-9059/10/2/344
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