The Paracaspase MALT1 in Cancer
Almost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified as relying on MALT1 to induce NF-κB activation. In...
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MDPI AG
2022-02-01
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Online Access: | https://www.mdpi.com/2227-9059/10/2/344 |
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author | Beatriz Gomez Solsona Anja Schmitt Klaus Schulze-Osthoff Stephan Hailfinger |
author_facet | Beatriz Gomez Solsona Anja Schmitt Klaus Schulze-Osthoff Stephan Hailfinger |
author_sort | Beatriz Gomez Solsona |
collection | DOAJ |
description | Almost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified as relying on MALT1 to induce NF-κB activation. In various hematological malignancies and solid tumors, MALT1 is constitutively activated and drives chronic NF-κB target gene expression. Deregulated MALT1 activity in cancer thus promotes tumor cell survival, proliferation, and metastasis. Since the molecular function of MALT1 partially requires its protease activity, pharmacological targeting of MALT1 may represent a promising anti-cancer strategy. Here, we review the molecular features of MALT1 activation and function as well as the therapeutic potential of MALT1 inhibition in hematological malignancies and solid tumors. |
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id | doaj.art-866060f0158b4346aedcc7135c945fc3 |
institution | Directory Open Access Journal |
issn | 2227-9059 |
language | English |
last_indexed | 2024-03-09T22:33:00Z |
publishDate | 2022-02-01 |
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series | Biomedicines |
spelling | doaj.art-866060f0158b4346aedcc7135c945fc32023-11-23T18:54:08ZengMDPI AGBiomedicines2227-90592022-02-0110234410.3390/biomedicines10020344The Paracaspase MALT1 in CancerBeatriz Gomez Solsona0Anja Schmitt1Klaus Schulze-Osthoff2Stephan Hailfinger3Interfaculty Institute of Biochemistry, University of Tuebingen, 72076 Tuebingen, GermanyDepartment of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, 48149 Muenster, GermanyInterfaculty Institute of Biochemistry, University of Tuebingen, 72076 Tuebingen, GermanyDepartment of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, 48149 Muenster, GermanyAlmost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified as relying on MALT1 to induce NF-κB activation. In various hematological malignancies and solid tumors, MALT1 is constitutively activated and drives chronic NF-κB target gene expression. Deregulated MALT1 activity in cancer thus promotes tumor cell survival, proliferation, and metastasis. Since the molecular function of MALT1 partially requires its protease activity, pharmacological targeting of MALT1 may represent a promising anti-cancer strategy. Here, we review the molecular features of MALT1 activation and function as well as the therapeutic potential of MALT1 inhibition in hematological malignancies and solid tumors.https://www.mdpi.com/2227-9059/10/2/344MALT1BCL10CARD11CARD10CBM complexNF-κB |
spellingShingle | Beatriz Gomez Solsona Anja Schmitt Klaus Schulze-Osthoff Stephan Hailfinger The Paracaspase MALT1 in Cancer Biomedicines MALT1 BCL10 CARD11 CARD10 CBM complex NF-κB |
title | The Paracaspase MALT1 in Cancer |
title_full | The Paracaspase MALT1 in Cancer |
title_fullStr | The Paracaspase MALT1 in Cancer |
title_full_unstemmed | The Paracaspase MALT1 in Cancer |
title_short | The Paracaspase MALT1 in Cancer |
title_sort | paracaspase malt1 in cancer |
topic | MALT1 BCL10 CARD11 CARD10 CBM complex NF-κB |
url | https://www.mdpi.com/2227-9059/10/2/344 |
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