A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, Indonesia
Background Neuroblastoma is the third most common tumor in children, after leukemia and retinoblastoma. The disease presents with a wide range of symptoms. Objective To assess the clinical profiles of children with neuroblastoma at Dr. Sardjito General Hospital from 2012-2016. Methods A retros...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2019-06-01
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| Series: | Paediatrica Indonesiana |
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| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2145 |
| _version_ | 1819102864343040000 |
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| author | Sutaryo Sutaryo Scolastika Dita Kristian |
| author_facet | Sutaryo Sutaryo Scolastika Dita Kristian |
| author_sort | Sutaryo Sutaryo |
| collection | DOAJ |
| description | Background Neuroblastoma is the third most common tumor in children, after leukemia and retinoblastoma. The disease presents with a wide range of symptoms.
Objective To assess the clinical profiles of children with neuroblastoma at Dr. Sardjito General Hospital from 2012-2016.
Methods A retrospective review of all children with neuroblastoma under 18 years of age in the Children’s Ward of Dr. Sardjito General Hospital, Yogyakarta from 2012-2016. Patients diagnosed and treated in other hospitals were excluded. Data were taken from the Yogyakarta Pediatric Cancer Registry (YPCR) and medical records. Outcomes were assessed by patient status: alive, died, or lost to follow-up.
Results A total of 40 subjects were included in this study. Six (15.0%) patients were diagnosed at <1 year of age, 26 (65.0%) patients at 1 to <5 years of age, 6 (15.0%) patients at 5 to <10 years of age, and 2 (5.0%) patients at ≥10 years of age. The male to female ratio was 1.5:1. Four (10.0%) patients had stage IV-S, 34 (85.0 %) patients had stage IV, and 2 (5.0 %) patients had stage II/III of the disease. Proptosis (40.0%) and abdominal mass (35.0%) were the most common chief complaints. Eight (20.0%) patients were alive at the end of observation, 15 (37.5%) died, and 17 (42.5%) were lost to follow-up. The deaths were mostly caused by sepsis.
Conclusion Most patients are diagnosed at the age of 1 to <5 years, with a median age of 3 years. Proptosis is the most common chief complaint. Most patients present in stage IV. Overall survival rate is very low. The high numbers of lost to follow-up should be noted. |
| first_indexed | 2024-12-22T01:41:20Z |
| format | Article |
| id | doaj.art-866141ac25514200b4ba06e1f3b33857 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-22T01:41:20Z |
| publishDate | 2019-06-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-866141ac25514200b4ba06e1f3b338572022-12-21T18:43:13ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2019-06-015931576310.14238/pi59.3.2019.157-632145A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, IndonesiaSutaryo SutaryoScolastika Dita KristianBackground Neuroblastoma is the third most common tumor in children, after leukemia and retinoblastoma. The disease presents with a wide range of symptoms. Objective To assess the clinical profiles of children with neuroblastoma at Dr. Sardjito General Hospital from 2012-2016. Methods A retrospective review of all children with neuroblastoma under 18 years of age in the Children’s Ward of Dr. Sardjito General Hospital, Yogyakarta from 2012-2016. Patients diagnosed and treated in other hospitals were excluded. Data were taken from the Yogyakarta Pediatric Cancer Registry (YPCR) and medical records. Outcomes were assessed by patient status: alive, died, or lost to follow-up. Results A total of 40 subjects were included in this study. Six (15.0%) patients were diagnosed at <1 year of age, 26 (65.0%) patients at 1 to <5 years of age, 6 (15.0%) patients at 5 to <10 years of age, and 2 (5.0%) patients at ≥10 years of age. The male to female ratio was 1.5:1. Four (10.0%) patients had stage IV-S, 34 (85.0 %) patients had stage IV, and 2 (5.0 %) patients had stage II/III of the disease. Proptosis (40.0%) and abdominal mass (35.0%) were the most common chief complaints. Eight (20.0%) patients were alive at the end of observation, 15 (37.5%) died, and 17 (42.5%) were lost to follow-up. The deaths were mostly caused by sepsis. Conclusion Most patients are diagnosed at the age of 1 to <5 years, with a median age of 3 years. Proptosis is the most common chief complaint. Most patients present in stage IV. Overall survival rate is very low. The high numbers of lost to follow-up should be noted.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2145neuroblastoma; pediatric; characteristic; overall survival; lmic |
| spellingShingle | Sutaryo Sutaryo Scolastika Dita Kristian A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, Indonesia Paediatrica Indonesiana neuroblastoma; pediatric; characteristic; overall survival; lmic |
| title | A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, Indonesia |
| title_full | A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, Indonesia |
| title_fullStr | A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, Indonesia |
| title_full_unstemmed | A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, Indonesia |
| title_short | A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, Indonesia |
| title_sort | five year review of children with neuroblastoma at dr sardjito general hospital yogyakarta indonesia |
| topic | neuroblastoma; pediatric; characteristic; overall survival; lmic |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2145 |
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