<i>Clostridium butyricum</i> Ameliorates the Effect of Coprophagy Prevention on Hepatic Lipid Synthesis in Rabbits via the Gut–Liver Axis
Coprophagy prevention (CP) affects the growth performance, hepatic lipid synthesis, and gut microbiota in rabbits. Supplementation with <i>Clostridium butyricum</i> (<i>C. butyricum,</i> Strain number: CCTCC M 2019962) has been found to improve growth performance in rabbits....
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/24/17554 |
| Summary: | Coprophagy prevention (CP) affects the growth performance, hepatic lipid synthesis, and gut microbiota in rabbits. Supplementation with <i>Clostridium butyricum</i> (<i>C. butyricum,</i> Strain number: CCTCC M 2019962) has been found to improve growth performance in rabbits. However, it remains unknown whether <i>C. butyricum</i> can ameliorate the effects of CP on hepatic lipid synthesis and the underlying mechanisms are yet to be elucidated. Therefore, this study aimed to investigate the impact of CP on hepatic lipid synthesis and the underlying mechanism based on the gut–liver axis. The findings revealed that supplementation with <i>C. butyricum</i> could reverse CP-related growth performance, lipid accumulation, bile acid synthesis, and inflammation. Furthermore, <i>C. butyricum</i> exerted protective effects on the gut by preserving intestinal barrier integrity and modulating gut microbiota composition; these factors may represent potential mechanisms through which <i>C. butyricum</i> improves CP-related outcomes. Specifically, <i>C. butyricum</i> reshaped the microbiota by increasing butyric acid levels, thereby maintaining secondary bile acid (deoxycholic acid, chenodeoxycholic acid) balance and attenuating the inhibitory effects of the FXR/SHP pathway on lipid synthesis (SREBP1c/ApoA1). Moreover, the activation of butyrate/GPR43pathway by <i>C. butyricum</i> reduced damage to the intestinal barrier (ZO-1/Occludin/Claudin1) and restored the gut immune microenvironment in CP rabbits. In summary, supplementation with <i>C. butyricum</i> can alleviate the adverse effects of CP on growth performance and hepatic lipid synthesis by modulating the gut–liver axis. |
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| ISSN: | 1661-6596 1422-0067 |