Nebulizer particle size distribution measured by various methods
Pari LC Sprint Star nebulizer is an inhaler device dedicated to delivering the liquid drug formulation into peripheral lung regions. The particle size is one of the critical parameters which determine the location of aerosol deposition within the human lungs. In this study, the particle size distrib...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2022-01-01
|
| Series: | EPJ Web of Conferences |
| Online Access: | https://www.epj-conferences.org/articles/epjconf/pdf/2022/08/epjconf_efm2022_01023.pdf |
| _version_ | 1811225507239297024 |
|---|---|
| author | Misik Ondrej Peštálová Andrea Belka Miloslav Lízal Frantisek |
| author_facet | Misik Ondrej Peštálová Andrea Belka Miloslav Lízal Frantisek |
| author_sort | Misik Ondrej |
| collection | DOAJ |
| description | Pari LC Sprint Star nebulizer is an inhaler device dedicated to delivering the liquid drug formulation into peripheral lung regions. The particle size is one of the critical parameters which determine the location of aerosol deposition within the human lungs. In this study, the particle size distribution of aerosol was measured by two different methods: Andersen Cascade Impactor (ACI) and Aerodynamic Particle Sizer (APS). Mass Median of Aerodynamic Distribution (MMAD), and Geometric Standard Deviation (GSD) were evaluated. MMAD gained by APS was approx. 7 µm, MMAD acquired by ACI was approx. 2.5 µm. According to the results, these two measuring methods are not very consistent, and the comparison of the particle size acquired by the different methods is not appropriate. |
| first_indexed | 2024-04-12T09:07:17Z |
| format | Article |
| id | doaj.art-86654882b4c44c279255a7f62d98bf68 |
| institution | Directory Open Access Journal |
| issn | 2100-014X |
| language | English |
| last_indexed | 2024-04-12T09:07:17Z |
| publishDate | 2022-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | EPJ Web of Conferences |
| spelling | doaj.art-86654882b4c44c279255a7f62d98bf682022-12-22T03:39:03ZengEDP SciencesEPJ Web of Conferences2100-014X2022-01-012640102310.1051/epjconf/202226401023epjconf_efm2022_01023Nebulizer particle size distribution measured by various methodsMisik Ondrej0Peštálová Andrea1Belka Miloslav2Lízal Frantisek3Faculty of Mechanical Engineering, Brno University of TechnologyFaculty of Pharmacy, Masaryk UniversityFaculty of Mechanical Engineering, Brno University of TechnologyFaculty of Mechanical Engineering, Brno University of TechnologyPari LC Sprint Star nebulizer is an inhaler device dedicated to delivering the liquid drug formulation into peripheral lung regions. The particle size is one of the critical parameters which determine the location of aerosol deposition within the human lungs. In this study, the particle size distribution of aerosol was measured by two different methods: Andersen Cascade Impactor (ACI) and Aerodynamic Particle Sizer (APS). Mass Median of Aerodynamic Distribution (MMAD), and Geometric Standard Deviation (GSD) were evaluated. MMAD gained by APS was approx. 7 µm, MMAD acquired by ACI was approx. 2.5 µm. According to the results, these two measuring methods are not very consistent, and the comparison of the particle size acquired by the different methods is not appropriate.https://www.epj-conferences.org/articles/epjconf/pdf/2022/08/epjconf_efm2022_01023.pdf |
| spellingShingle | Misik Ondrej Peštálová Andrea Belka Miloslav Lízal Frantisek Nebulizer particle size distribution measured by various methods EPJ Web of Conferences |
| title | Nebulizer particle size distribution measured by various methods |
| title_full | Nebulizer particle size distribution measured by various methods |
| title_fullStr | Nebulizer particle size distribution measured by various methods |
| title_full_unstemmed | Nebulizer particle size distribution measured by various methods |
| title_short | Nebulizer particle size distribution measured by various methods |
| title_sort | nebulizer particle size distribution measured by various methods |
| url | https://www.epj-conferences.org/articles/epjconf/pdf/2022/08/epjconf_efm2022_01023.pdf |
| work_keys_str_mv | AT misikondrej nebulizerparticlesizedistributionmeasuredbyvariousmethods AT pestalovaandrea nebulizerparticlesizedistributionmeasuredbyvariousmethods AT belkamiloslav nebulizerparticlesizedistributionmeasuredbyvariousmethods AT lizalfrantisek nebulizerparticlesizedistributionmeasuredbyvariousmethods |