HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk.
Misclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed as a potential risk marker. Hence,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4254940?pdf=render |
| _version_ | 1828337531591065600 |
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| author | Eliane Soler Parra Natalia Baratella Panzoldo Vanessa Helena de Souza Zago Daniel Zanetti Scherrer Fernanda Alexandre Jamal Bakkarat Valeria Sutti Nunes Edna Regina Nakandakare Eder Carlos Rocha Quintão Wilson Nadruz Eliana Cotta de Faria Andrei C Sposito |
| author_facet | Eliane Soler Parra Natalia Baratella Panzoldo Vanessa Helena de Souza Zago Daniel Zanetti Scherrer Fernanda Alexandre Jamal Bakkarat Valeria Sutti Nunes Edna Regina Nakandakare Eder Carlos Rocha Quintão Wilson Nadruz Eliana Cotta de Faria Andrei C Sposito |
| author_sort | Eliane Soler Parra |
| collection | DOAJ |
| description | Misclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed as a potential risk marker. Hence, we investigate whether HDL size improves the predictive value of HDL-cholesterol in the identification of carotid atherosclerotic burden in individuals stratified to be at LCR.284 individuals (40-75 years) classified as LCR by the current US guidelines were selected in a three-step procedure from primary care centers of the cities of Campinas and Americana, SP, Brazil. Apolipoprotein B-containing lipoproteins were precipitated by polyethylene glycol and HDL size was measured by dynamic light scattering (DLS) technique. Participants were classified in tertiles of HDL size (<7.57; 7.57-8.22; >8.22 nm). Carotid intima-media thickness (cIMT) <0.90 mm (80th percentile) was determined by high resolution ultrasonography and multivariate ordinal regression models were used to assess the association between cIMT across HDL size and levels of lipid parameters. HDL-cholesterol was not associated with cIMT. In contrast, HDL size >8.22 nm was independently associated with low cIMT in either unadjusted and adjusted models for age, gender and Homeostasis Model Assessment 2 index for insulin sensitivity, ethnicity and body mass index (Odds ratio 0.23; 95% confidence interval 0.07-0.74, p = 0.013).The mean HDL size estimated with DLS constitutes a better predictor for subclinical carotid atherosclerosis than the conventional measurements of plasma HDL-cholesterol in individuals classified as LCR. |
| first_indexed | 2024-04-13T22:15:39Z |
| format | Article |
| id | doaj.art-86668582f444441c8eaf6360ee43cfaa |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T22:15:39Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-86668582f444441c8eaf6360ee43cfaa2022-12-22T02:27:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11421210.1371/journal.pone.0114212HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk.Eliane Soler ParraNatalia Baratella PanzoldoVanessa Helena de Souza ZagoDaniel Zanetti ScherrerFernanda AlexandreJamal BakkaratValeria Sutti NunesEdna Regina NakandakareEder Carlos Rocha QuintãoWilson NadruzEliana Cotta de FariaAndrei C SpositoMisclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed as a potential risk marker. Hence, we investigate whether HDL size improves the predictive value of HDL-cholesterol in the identification of carotid atherosclerotic burden in individuals stratified to be at LCR.284 individuals (40-75 years) classified as LCR by the current US guidelines were selected in a three-step procedure from primary care centers of the cities of Campinas and Americana, SP, Brazil. Apolipoprotein B-containing lipoproteins were precipitated by polyethylene glycol and HDL size was measured by dynamic light scattering (DLS) technique. Participants were classified in tertiles of HDL size (<7.57; 7.57-8.22; >8.22 nm). Carotid intima-media thickness (cIMT) <0.90 mm (80th percentile) was determined by high resolution ultrasonography and multivariate ordinal regression models were used to assess the association between cIMT across HDL size and levels of lipid parameters. HDL-cholesterol was not associated with cIMT. In contrast, HDL size >8.22 nm was independently associated with low cIMT in either unadjusted and adjusted models for age, gender and Homeostasis Model Assessment 2 index for insulin sensitivity, ethnicity and body mass index (Odds ratio 0.23; 95% confidence interval 0.07-0.74, p = 0.013).The mean HDL size estimated with DLS constitutes a better predictor for subclinical carotid atherosclerosis than the conventional measurements of plasma HDL-cholesterol in individuals classified as LCR.http://europepmc.org/articles/PMC4254940?pdf=render |
| spellingShingle | Eliane Soler Parra Natalia Baratella Panzoldo Vanessa Helena de Souza Zago Daniel Zanetti Scherrer Fernanda Alexandre Jamal Bakkarat Valeria Sutti Nunes Edna Regina Nakandakare Eder Carlos Rocha Quintão Wilson Nadruz Eliana Cotta de Faria Andrei C Sposito HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk. PLoS ONE |
| title | HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk. |
| title_full | HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk. |
| title_fullStr | HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk. |
| title_full_unstemmed | HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk. |
| title_short | HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk. |
| title_sort | hdl size is more accurate than hdl cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk |
| url | http://europepmc.org/articles/PMC4254940?pdf=render |
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