CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents

CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions, most importantly cell division and transcription, and their dysregulations have been implicated as prominent drivers of tumorigenesis. Besides the well-established role of cell cycle CDKs in cancer, the invol...

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Bibliographic Details
Main Authors: Abel Tesfaye Anshabo, Robert Milne, Shudong Wang, Hugo Albrecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
cancer
CDKs
transcription
P-TEFb
CDK9 inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.678559/full

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