Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity

Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity

ABSTRACT Most bacteria employ a two-step indirect tRNA aminoacylation pathway for the synthesis of aminoacylated tRNAGln and tRNAAsn. The heterotrimeric enzyme GatCAB performs a critical amidotransferase reaction in the second step of this pathway. We have previously demonstrated in mycobacteria tha...

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Bibliographic Details
Main Authors: Yang-Yang Li, Rong-Jun Cai, Jia-Ying Yang, Tamara L. Hendrickson, Ye Xiang, Babak Javid
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
GatCAB
translational fidelity
mycobacterium
transamidosome
mistranslation
Mycobacterium tuberculosis
Online Access:https://journals.asm.org/doi/10.1128/mBio.01100-21

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