Herbal medicinal products in the treatment of depression
For dry hydroalcoholic extracts of St. John's wort herb, Hyperici herba (Hypericum perforatum, Hypericaceae), it was demonstrated in clinical trials that in the treatment of mild to moderate (but not severe) major depression, they are more effective than placebo, and as effective as some standa...
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2017-01-01
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| Series: | Arhiv za farmaciju |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2017/0004-19631705302P.pdf |
| _version_ | 1818623773239148544 |
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| author | Petrović Silvana |
| author_facet | Petrović Silvana |
| author_sort | Petrović Silvana |
| collection | DOAJ |
| description | For dry hydroalcoholic extracts of St. John's wort herb, Hyperici herba (Hypericum perforatum, Hypericaceae), it was demonstrated in clinical trials that in the treatment of mild to moderate (but not severe) major depression, they are more effective than placebo, and as effective as some standard antidepressants. These extracts represent complex mixtures of structurally diverse constituents with various mechanisms of action. The quantity of active components can vary among different extracts. The Committee on Herbal Medicinal Products of the European Medicines Agency (EMA/HMPC) published monograph on St. John's wort herb, Hyperici herba, according to which these extracts are the components of herbal medicinal products with well-established medicinal use of the active substance, intended for the treatment of mild to moderate depressive episodes and for the short term treatment of symptoms in mild depressive disorders. These herbal drugs are characterized by good tolerability. Compared to synthetic antidepressants, they cause less undesirable effects. However, they exhibit interactions with the large number of drugs, due to the induction of the isoenzymes of cytochrome P450 system (CYP, primarily CYP3A4) and P-glycoprotein, as well as the potentiation of serotonergic effects. Because of mentioned interactions, for these herbal drugs appropriate contraindications, special warnings and precautions for use were established. |
| first_indexed | 2024-12-16T18:46:23Z |
| format | Article |
| id | doaj.art-8669166f8b58479ba994261bf067ff5a |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-12-16T18:46:23Z |
| publishDate | 2017-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-8669166f8b58479ba994261bf067ff5a2022-12-21T22:20:49ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672017-01-0167530231410.5937/arhfarm1705302P0004-19631705302PHerbal medicinal products in the treatment of depressionPetrović Silvana0https://orcid.org/0000-0003-0787-3077Univerzitet u Beogradu, Farmaceutski fakultet, Katedra za farmakognoziju, Beograd, SerbiaFor dry hydroalcoholic extracts of St. John's wort herb, Hyperici herba (Hypericum perforatum, Hypericaceae), it was demonstrated in clinical trials that in the treatment of mild to moderate (but not severe) major depression, they are more effective than placebo, and as effective as some standard antidepressants. These extracts represent complex mixtures of structurally diverse constituents with various mechanisms of action. The quantity of active components can vary among different extracts. The Committee on Herbal Medicinal Products of the European Medicines Agency (EMA/HMPC) published monograph on St. John's wort herb, Hyperici herba, according to which these extracts are the components of herbal medicinal products with well-established medicinal use of the active substance, intended for the treatment of mild to moderate depressive episodes and for the short term treatment of symptoms in mild depressive disorders. These herbal drugs are characterized by good tolerability. Compared to synthetic antidepressants, they cause less undesirable effects. However, they exhibit interactions with the large number of drugs, due to the induction of the isoenzymes of cytochrome P450 system (CYP, primarily CYP3A4) and P-glycoprotein, as well as the potentiation of serotonergic effects. Because of mentioned interactions, for these herbal drugs appropriate contraindications, special warnings and precautions for use were established.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2017/0004-19631705302P.pdfst. john's wort herb - hyperici herbaherbal drugs for the treatment of depressionqualityefficacy and mechanisms of actionsafety |
| spellingShingle | Petrović Silvana Herbal medicinal products in the treatment of depression Arhiv za farmaciju st. john's wort herb - hyperici herba herbal drugs for the treatment of depression quality efficacy and mechanisms of action safety |
| title | Herbal medicinal products in the treatment of depression |
| title_full | Herbal medicinal products in the treatment of depression |
| title_fullStr | Herbal medicinal products in the treatment of depression |
| title_full_unstemmed | Herbal medicinal products in the treatment of depression |
| title_short | Herbal medicinal products in the treatment of depression |
| title_sort | herbal medicinal products in the treatment of depression |
| topic | st. john's wort herb - hyperici herba herbal drugs for the treatment of depression quality efficacy and mechanisms of action safety |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2017/0004-19631705302P.pdf |
| work_keys_str_mv | AT petrovicsilvana herbalmedicinalproductsinthetreatmentofdepression |