Clinical outcomes of atrial fibrillation with hyperthyroidism
Abstract Background Atrial fibrillation (Afib) is a common cardiac manifestation of hyperthyroidism. The data regarding outcomes of Afib with and without hyperthyroidism are lacking. Hypothesis We hypothesized that patients with Afib and hyperthyroidism have better clinical outcomes, compared with A...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Journal of Arrhythmia |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/joa3.12550 |
| _version_ | 1818599555249209344 |
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| author | Muhammad Zubair Khan Ashwani Gupta Jordesha Hodge Kirtenkumar Patel Krunalkumar Patel Muhammad Samsoor Zarak Sona Franklin Harsh Patel Shruti Jesani Sejal Savani Vraj Shah Vincent M. Figueredo Arvind R. Cavale Steven Kutalek |
| author_facet | Muhammad Zubair Khan Ashwani Gupta Jordesha Hodge Kirtenkumar Patel Krunalkumar Patel Muhammad Samsoor Zarak Sona Franklin Harsh Patel Shruti Jesani Sejal Savani Vraj Shah Vincent M. Figueredo Arvind R. Cavale Steven Kutalek |
| author_sort | Muhammad Zubair Khan |
| collection | DOAJ |
| description | Abstract Background Atrial fibrillation (Afib) is a common cardiac manifestation of hyperthyroidism. The data regarding outcomes of Afib with and without hyperthyroidism are lacking. Hypothesis We hypothesized that patients with Afib and hyperthyroidism have better clinical outcomes, compared with Afib patients without hyperthyroidism. Methods We queried the National Inpatient Sample database for years 2015‐2017 using Validated ICD‐10‐CM codes for Afib and hyperthyroidism. Patients were separated into two groups, Afib with hyperthyroidism and without hyperthyroidism. Results The study was conducted with 68 095 278 patients. A total of 9 727 295 Afib patients were identified, 90 635 (0.9%) had hyperthyroidism. The prevalence of hyperthyroidism was higher in patients with Afib (0.9% vs 0.4%, P < .001), compared with patients without Afib. Using multivariate regression analysis adjusting for various confounding factors, the odds ratio of Afib with hyperthyroidism was 2.08 (CI 2.07‐2.10; P < .0001). Afib patients with hyperthyroidism were younger (71 vs 75 years, P < .0001) and more likely to be female (64% vs 47%; P < .0001) as compared with Afib patients without hyperthyroidism. Afib patients with hyperthyroidism had lower prevalence of CAD (36% vs 44%, P < .0001), cardiomyopathy (24.1% vs 25.9%, P < .0001), valvular disease (6.9% vs 7.4%, P < .0001), hypertension (60.7% vs 64.4%, P < .0001), diabetes mellitus (29% vs 32%, P < .0001) and obstructive sleep apnea (10.5% vs 12.2%, P < .0001). Afib with hyperthyroidism had lower hospitalization cost ($14 968 ± 21 871 vs $15 955 ± 22 233, P < .0001), shorter mean length of stay (5.7 ± 6.6 vs 5.9 ± 6.6 days, P < .0001) and lower in‐hospital mortality (3.3% vs 4.8%, P < .0001. The disposition to home was higher in Afib with hyperthyroidism patients (51% vs 42; P < .0001). Conclusion Hyperthyroidism is associated with Afib in both univariate and multivariate analysis. Afib patients with hyperthyroidism have better clinical outcomes, compared with Afib patients without hyperthyroidism. |
| first_indexed | 2024-12-16T12:21:27Z |
| format | Article |
| id | doaj.art-866cf5b33f8b470a8bca9ad44ec3d691 |
| institution | Directory Open Access Journal |
| issn | 1880-4276 1883-2148 |
| language | English |
| last_indexed | 2024-12-16T12:21:27Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-866cf5b33f8b470a8bca9ad44ec3d6912022-12-21T22:31:57ZengWileyJournal of Arrhythmia1880-42761883-21482021-08-0137494294810.1002/joa3.12550Clinical outcomes of atrial fibrillation with hyperthyroidismMuhammad Zubair Khan0Ashwani Gupta1Jordesha Hodge2Kirtenkumar Patel3Krunalkumar Patel4Muhammad Samsoor Zarak5Sona Franklin6Harsh Patel7Shruti Jesani8Sejal Savani9Vraj Shah10Vincent M. Figueredo11Arvind R. Cavale12Steven Kutalek13Department of Internal Medicine St. Mary Medical Center Langhorne PA USADivision of Cardiology St. Mary Medical Center Langhorne PA USADepartment of Internal Medicine St. Mary Medical Center Langhorne PA USADepartment of Cardiology North Shore University Hospital Manhasset NY USADepartment of Internal Medicine St. Mary Medical Center Langhorne PA USAPost Doc Research Fellow West Virginia University of Medicine Morgantown WV USADepartment of Internal Medicine St. Mary Medical Center Langhorne PA USADepartment of Internal Medicine Louis A Weiss Memorial Hospital Chicago IL USADepartment of Internal Medicine Trinitas Regional Medical Center Elizabeth NJ USANYU College of Dentistry New York NY USADivision of Cardiology Medical College of Baroda Vadodara IndiaDivision of Cardiology St. Mary Medical Center Langhorne PA USADepartment of Medicine St. Mary Medical Center Langhorne PA USADepartment of Cardiology Drexel University College of Medicine Philadelphia PA USAAbstract Background Atrial fibrillation (Afib) is a common cardiac manifestation of hyperthyroidism. The data regarding outcomes of Afib with and without hyperthyroidism are lacking. Hypothesis We hypothesized that patients with Afib and hyperthyroidism have better clinical outcomes, compared with Afib patients without hyperthyroidism. Methods We queried the National Inpatient Sample database for years 2015‐2017 using Validated ICD‐10‐CM codes for Afib and hyperthyroidism. Patients were separated into two groups, Afib with hyperthyroidism and without hyperthyroidism. Results The study was conducted with 68 095 278 patients. A total of 9 727 295 Afib patients were identified, 90 635 (0.9%) had hyperthyroidism. The prevalence of hyperthyroidism was higher in patients with Afib (0.9% vs 0.4%, P < .001), compared with patients without Afib. Using multivariate regression analysis adjusting for various confounding factors, the odds ratio of Afib with hyperthyroidism was 2.08 (CI 2.07‐2.10; P < .0001). Afib patients with hyperthyroidism were younger (71 vs 75 years, P < .0001) and more likely to be female (64% vs 47%; P < .0001) as compared with Afib patients without hyperthyroidism. Afib patients with hyperthyroidism had lower prevalence of CAD (36% vs 44%, P < .0001), cardiomyopathy (24.1% vs 25.9%, P < .0001), valvular disease (6.9% vs 7.4%, P < .0001), hypertension (60.7% vs 64.4%, P < .0001), diabetes mellitus (29% vs 32%, P < .0001) and obstructive sleep apnea (10.5% vs 12.2%, P < .0001). Afib with hyperthyroidism had lower hospitalization cost ($14 968 ± 21 871 vs $15 955 ± 22 233, P < .0001), shorter mean length of stay (5.7 ± 6.6 vs 5.9 ± 6.6 days, P < .0001) and lower in‐hospital mortality (3.3% vs 4.8%, P < .0001. The disposition to home was higher in Afib with hyperthyroidism patients (51% vs 42; P < .0001). Conclusion Hyperthyroidism is associated with Afib in both univariate and multivariate analysis. Afib patients with hyperthyroidism have better clinical outcomes, compared with Afib patients without hyperthyroidism.https://doi.org/10.1002/joa3.12550arrhythmiaatrial fibrillationhyperthyroidism |
| spellingShingle | Muhammad Zubair Khan Ashwani Gupta Jordesha Hodge Kirtenkumar Patel Krunalkumar Patel Muhammad Samsoor Zarak Sona Franklin Harsh Patel Shruti Jesani Sejal Savani Vraj Shah Vincent M. Figueredo Arvind R. Cavale Steven Kutalek Clinical outcomes of atrial fibrillation with hyperthyroidism Journal of Arrhythmia arrhythmia atrial fibrillation hyperthyroidism |
| title | Clinical outcomes of atrial fibrillation with hyperthyroidism |
| title_full | Clinical outcomes of atrial fibrillation with hyperthyroidism |
| title_fullStr | Clinical outcomes of atrial fibrillation with hyperthyroidism |
| title_full_unstemmed | Clinical outcomes of atrial fibrillation with hyperthyroidism |
| title_short | Clinical outcomes of atrial fibrillation with hyperthyroidism |
| title_sort | clinical outcomes of atrial fibrillation with hyperthyroidism |
| topic | arrhythmia atrial fibrillation hyperthyroidism |
| url | https://doi.org/10.1002/joa3.12550 |
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