Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality

Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality

During systemic inflammation, reactive oxygen species (ROS) are generated in the bloodstream, producing large amounts of oxidized HDL (oxHDL). OxHDL loses the vascular protective features of native HDL, acquiring detrimental actions. Systemic inflammation promotes endothelial fibrosis, characterized...

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Bibliographic Details
Main Authors: Macarena Rojas, Yolanda Prado, Pablo Tapia, Leandro J. Carreño, Claudio Cabello-Verrugio, Felipe Simon
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antioxidants
Subjects:
oxHDL
oxidative stress
endothelium
fibrosis
blood pressure
mortality
Online Access:https://www.mdpi.com/2076-3921/11/12/2469

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