Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases
Palmoplantar pustulosis (PPP) is a disease that causes recurrent blisters and aseptic pustules on the palms and soles. It has been suggested that both innate and acquired immunity are involved. In particular, based on the tonsils and basic experiments, it has been assumed that T and B cells are invo...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8261 |
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| author | Takemichi Fukasawa Asako Yoshizaki-Ogawa Atsushi Enomoto Kiyoshi Miyagawa Shinichi Sato Ayumi Yoshizaki |
| author_facet | Takemichi Fukasawa Asako Yoshizaki-Ogawa Atsushi Enomoto Kiyoshi Miyagawa Shinichi Sato Ayumi Yoshizaki |
| author_sort | Takemichi Fukasawa |
| collection | DOAJ |
| description | Palmoplantar pustulosis (PPP) is a disease that causes recurrent blisters and aseptic pustules on the palms and soles. It has been suggested that both innate and acquired immunity are involved. In particular, based on the tonsils and basic experiments, it has been assumed that T and B cells are involved in its pathogenesis. In addition, the results of clinical trials have suggested that IL-23 is closely related to the pathogenesis. This review describes PPP and the genetic background, the factors involved in the onset and exacerbation of disease and its relation to the molecular mechanism. In addition, we describe the usefulness of biological therapy and its implications in relation to the importance in pathology, the pathogenesis of PPP, the importance of the role of the IL-23–Th17 axis and IL-36 in PPP. Furthermore, we describe an animal experimental model of PPP, the efficacy and mechanism of action of guselkumab, an anti-IL-23 antibody, the latest research, and finally the possibility for it to be effective for other autoimmune diseases. |
| first_indexed | 2024-03-09T12:36:05Z |
| format | Article |
| id | doaj.art-8673845748184f6cbef030745636c6eb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:36:05Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8673845748184f6cbef030745636c6eb2023-11-30T22:24:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315826110.3390/ijms23158261Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune DiseasesTakemichi Fukasawa0Asako Yoshizaki-Ogawa1Atsushi Enomoto2Kiyoshi Miyagawa3Shinichi Sato4Ayumi Yoshizaki5Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, JapanDepartment of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, JapanLaboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, JapanLaboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, JapanDepartment of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, JapanDepartment of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, JapanPalmoplantar pustulosis (PPP) is a disease that causes recurrent blisters and aseptic pustules on the palms and soles. It has been suggested that both innate and acquired immunity are involved. In particular, based on the tonsils and basic experiments, it has been assumed that T and B cells are involved in its pathogenesis. In addition, the results of clinical trials have suggested that IL-23 is closely related to the pathogenesis. This review describes PPP and the genetic background, the factors involved in the onset and exacerbation of disease and its relation to the molecular mechanism. In addition, we describe the usefulness of biological therapy and its implications in relation to the importance in pathology, the pathogenesis of PPP, the importance of the role of the IL-23–Th17 axis and IL-36 in PPP. Furthermore, we describe an animal experimental model of PPP, the efficacy and mechanism of action of guselkumab, an anti-IL-23 antibody, the latest research, and finally the possibility for it to be effective for other autoimmune diseases.https://www.mdpi.com/1422-0067/23/15/8261palmoplantar pustulosisB cellsT cellsIL-23anti-IL-23 antibody |
| spellingShingle | Takemichi Fukasawa Asako Yoshizaki-Ogawa Atsushi Enomoto Kiyoshi Miyagawa Shinichi Sato Ayumi Yoshizaki Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases International Journal of Molecular Sciences palmoplantar pustulosis B cells T cells IL-23 anti-IL-23 antibody |
| title | Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases |
| title_full | Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases |
| title_fullStr | Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases |
| title_full_unstemmed | Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases |
| title_short | Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases |
| title_sort | involvement of molecular mechanisms between t b cells and il 23 from palmoplantar pustulosis to autoimmune diseases |
| topic | palmoplantar pustulosis B cells T cells IL-23 anti-IL-23 antibody |
| url | https://www.mdpi.com/1422-0067/23/15/8261 |
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