Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook
Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction-oxidation (redox) signaling complex and is pivotal for the pathophysiology of some diseases. TXNIP increa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/5/2754 |
| _version_ | 1797542124003000320 |
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| author | Naila Qayyum Muhammad Haseeb Moon Suk Kim Sangdun Choi |
| author_facet | Naila Qayyum Muhammad Haseeb Moon Suk Kim Sangdun Choi |
| author_sort | Naila Qayyum |
| collection | DOAJ |
| description | Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction-oxidation (redox) signaling complex and is pivotal for the pathophysiology of some diseases. TXNIP increases reactive oxygen species production and oxidative stress and thereby contributes to apoptosis. Recent studies indicate an evolving role of TXNIP in the pathogenesis of complex diseases such as metabolic disorders, neurological disorders, and inflammatory illnesses. In addition, TXNIP has gained significant attention due to its wide range of functions in energy metabolism, insulin sensitivity, improved insulin secretion, and also in the regulation of glucose and tumor suppressor activities in various cancers. This review aims to highlight the roles of TXNIP in the field of diabetology, neurodegenerative diseases, and inflammation. TXNIP is found to be a promising novel therapeutic target in the current review, not only in the aforementioned diseases but also in prolonged microvascular and macrovascular diseases. Therefore, TXNIP inhibitors hold promise for preventing the growing incidence of complications in relevant diseases. |
| first_indexed | 2024-03-10T13:25:15Z |
| format | Article |
| id | doaj.art-8673cfed2f064188ba11ed2cd969e6ff |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:25:15Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8673cfed2f064188ba11ed2cd969e6ff2023-11-21T09:41:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01225275410.3390/ijms22052754Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic OutlookNaila Qayyum0Muhammad Haseeb1Moon Suk Kim2Sangdun Choi3Department of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaThioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction-oxidation (redox) signaling complex and is pivotal for the pathophysiology of some diseases. TXNIP increases reactive oxygen species production and oxidative stress and thereby contributes to apoptosis. Recent studies indicate an evolving role of TXNIP in the pathogenesis of complex diseases such as metabolic disorders, neurological disorders, and inflammatory illnesses. In addition, TXNIP has gained significant attention due to its wide range of functions in energy metabolism, insulin sensitivity, improved insulin secretion, and also in the regulation of glucose and tumor suppressor activities in various cancers. This review aims to highlight the roles of TXNIP in the field of diabetology, neurodegenerative diseases, and inflammation. TXNIP is found to be a promising novel therapeutic target in the current review, not only in the aforementioned diseases but also in prolonged microvascular and macrovascular diseases. Therefore, TXNIP inhibitors hold promise for preventing the growing incidence of complications in relevant diseases.https://www.mdpi.com/1422-0067/22/5/2754thioredoxinTXNIPmetabolic disordersneurological disordersTXNIP modulator |
| spellingShingle | Naila Qayyum Muhammad Haseeb Moon Suk Kim Sangdun Choi Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook International Journal of Molecular Sciences thioredoxin TXNIP metabolic disorders neurological disorders TXNIP modulator |
| title | Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook |
| title_full | Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook |
| title_fullStr | Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook |
| title_full_unstemmed | Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook |
| title_short | Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook |
| title_sort | role of thioredoxin interacting protein in diseases and its therapeutic outlook |
| topic | thioredoxin TXNIP metabolic disorders neurological disorders TXNIP modulator |
| url | https://www.mdpi.com/1422-0067/22/5/2754 |
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