Pharmaceutical systematics: Description and preliminary investigation of an alternative method for structuring drug information
Objectives: To identify the 30 most common adverse drug events or reactions (ADE/ADRs) within the top 200 medications: (1) by raw incidence, (2) weighted by prescription volume, (3) and weighted by retail dollars. Methods: The Pharmacy Times Top 200 Medications (as ranked by prescription volume)...
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| Format: | Article |
| Language: | English |
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University of Minnesota Libraries Publishing
2011-01-01
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| Series: | INNOVATIONS in Pharmacy |
| Subjects: | |
| Online Access: | https://pubs.lib.umn.edu/index.php/innovations/article/view/219 |
| _version_ | 1811265988231954432 |
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| author | Mary E. Kiersma Aleda M. H. Chen Kristin R. Villa Brian M. Shepler Matthew M. Murawski |
| author_facet | Mary E. Kiersma Aleda M. H. Chen Kristin R. Villa Brian M. Shepler Matthew M. Murawski |
| author_sort | Mary E. Kiersma |
| collection | DOAJ |
| description | Objectives: To identify the 30 most common adverse drug events or reactions (ADE/ADRs) within the top 200 medications: (1) by raw incidence, (2) weighted by prescription volume, (3) and weighted by retail dollars.
Methods: The Pharmacy Times Top 200 Medications (as ranked by prescription volume) was utilized to identify the top 200 medications in 2008. The ADE/ADRs for each medication were obtained from Facts and Comparisons, Micromedex, and Lexi-Comp and entered into a database. These ADE/ADRs were compiled and summed, identifying the number of times each appeared. These then were ranked to identify the 30 most common ADE/ADRs. The actual prescription volume and total retail dollars for each medication were obtained and listed next to each medication's ADE/ADR. The incidence of each ADE/ADR then was weighted by actual prescription volume and retail dollars to determine the top 30 most common ADE/ADRs.
Results: Initial evaluation resulted in 9829 individual ADE/ADRs and summed into 1477 distinct ADE/ADRs, after adjusting for interchangeable terminology. Examples of the 30 most common ADE/ADRs (raw incidence) included: dizziness/vertigo, headache, nausea, vomiting, and diarrhea/loose stools. The list remained the same after weighting by actual prescription volume. After weighting by retail dollars, the order of ADE/ADRs changed slightly.
Conclusion: Knowledge of ADE/ADRs is important for pharmacists in all healthcare settings. Consolidating ADE/ADRs for medications may enable pharmacists to recall the most common side effects and aid in earlier identification of ADE/ADRs, which may positively impact patient safety across practice settings.
Type: Original Research |
| first_indexed | 2024-04-12T20:33:59Z |
| format | Article |
| id | doaj.art-8674173e8ba44207b27bc2ae3f0c1772 |
| institution | Directory Open Access Journal |
| issn | 2155-0417 |
| language | English |
| last_indexed | 2024-04-12T20:33:59Z |
| publishDate | 2011-01-01 |
| publisher | University of Minnesota Libraries Publishing |
| record_format | Article |
| series | INNOVATIONS in Pharmacy |
| spelling | doaj.art-8674173e8ba44207b27bc2ae3f0c17722022-12-22T03:17:39ZengUniversity of Minnesota Libraries PublishingINNOVATIONS in Pharmacy2155-04172011-01-012110.24926/iip.v2i1.219Pharmaceutical systematics: Description and preliminary investigation of an alternative method for structuring drug informationMary E. KiersmaAleda M. H. ChenKristin R. VillaBrian M. SheplerMatthew M. MurawskiObjectives: To identify the 30 most common adverse drug events or reactions (ADE/ADRs) within the top 200 medications: (1) by raw incidence, (2) weighted by prescription volume, (3) and weighted by retail dollars. Methods: The Pharmacy Times Top 200 Medications (as ranked by prescription volume) was utilized to identify the top 200 medications in 2008. The ADE/ADRs for each medication were obtained from Facts and Comparisons, Micromedex, and Lexi-Comp and entered into a database. These ADE/ADRs were compiled and summed, identifying the number of times each appeared. These then were ranked to identify the 30 most common ADE/ADRs. The actual prescription volume and total retail dollars for each medication were obtained and listed next to each medication's ADE/ADR. The incidence of each ADE/ADR then was weighted by actual prescription volume and retail dollars to determine the top 30 most common ADE/ADRs. Results: Initial evaluation resulted in 9829 individual ADE/ADRs and summed into 1477 distinct ADE/ADRs, after adjusting for interchangeable terminology. Examples of the 30 most common ADE/ADRs (raw incidence) included: dizziness/vertigo, headache, nausea, vomiting, and diarrhea/loose stools. The list remained the same after weighting by actual prescription volume. After weighting by retail dollars, the order of ADE/ADRs changed slightly. Conclusion: Knowledge of ADE/ADRs is important for pharmacists in all healthcare settings. Consolidating ADE/ADRs for medications may enable pharmacists to recall the most common side effects and aid in earlier identification of ADE/ADRs, which may positively impact patient safety across practice settings. Type: Original Researchhttps://pubs.lib.umn.edu/index.php/innovations/article/view/219adverse drug reactionadverse drug event |
| spellingShingle | Mary E. Kiersma Aleda M. H. Chen Kristin R. Villa Brian M. Shepler Matthew M. Murawski Pharmaceutical systematics: Description and preliminary investigation of an alternative method for structuring drug information INNOVATIONS in Pharmacy adverse drug reaction adverse drug event |
| title | Pharmaceutical systematics: Description and preliminary investigation of an alternative method for structuring drug information |
| title_full | Pharmaceutical systematics: Description and preliminary investigation of an alternative method for structuring drug information |
| title_fullStr | Pharmaceutical systematics: Description and preliminary investigation of an alternative method for structuring drug information |
| title_full_unstemmed | Pharmaceutical systematics: Description and preliminary investigation of an alternative method for structuring drug information |
| title_short | Pharmaceutical systematics: Description and preliminary investigation of an alternative method for structuring drug information |
| title_sort | pharmaceutical systematics description and preliminary investigation of an alternative method for structuring drug information |
| topic | adverse drug reaction adverse drug event |
| url | https://pubs.lib.umn.edu/index.php/innovations/article/view/219 |
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