Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration

Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration

Low back pain (LBP) is a prevalent health problem worldwide that affects over 80% of adults during their lifetime. Intervertebral disc degeneration (IDD) is a well-recognized leading cause of LBP. IDD is classified into five grades according to the Pfirrmann classification system. The purpose of thi...

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Bibliographic Details
Main Authors: Xiao Yang, Yang Lu, Hang Zhou, Hai-Tao Jiang, Lei Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
bioinformatics
machine learning
bulk RNA sequencing
intervertebral disc degeneration
single-cell RNA sequencing
proteome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1136777/full

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