Role of Opioid System in Empathy-like Behaviours in Rats
Background: Empathy is defined as the ability to simulate the mental states of others. Recent studies havedemonstrated empathy-like behaviors in other animals including rats and mice. The objective of the currentstudy was to evaluate the effect of acute administration of morphine and naloxone on cog...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2019-12-01
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| Series: | Addiction and Health |
| Subjects: | |
| Online Access: | https://ahj.kmu.ac.ir/article_89553_91d5c9317e4b93368822ffa10d21761b.pdf |
| _version_ | 1797681937453678592 |
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| author | Masoud Nazeri Akram Nezhadi Mohammad Shabani |
| author_facet | Masoud Nazeri Akram Nezhadi Mohammad Shabani |
| author_sort | Masoud Nazeri |
| collection | DOAJ |
| description | Background: Empathy is defined as the ability to simulate the mental states of others. Recent studies havedemonstrated empathy-like behaviors in other animals including rats and mice. The objective of the currentstudy was to evaluate the effect of acute administration of morphine and naloxone on cognition andnociception changes following observing conspecifics undergoing nociceptive stimulus.Methods: Adult male Wistar rats were used (n = 8 for each group). One cagemate received formalin injectioninto the hindpaw five times within a nine-day period and the other cagemate observed the pain while beingpretreated with saline, morphine, or naloxone [10 mg/kg, intraperitoneal (i.p.)]. Pain behaviors, anxiety-likebehaviour, locomotion, balance and muscle strength were evaluated in the observer animals.Findings: Observing a cagemate in pain increased anxiety-like behavior and reduced thermal pain threshold in theobserver animals. Administration of morphine reversed these effects and naloxone did not affect the responses.Conclusion: Results of the current study reveal an important role for opioid receptors (ORs) in empathy forpain, so that activation of this system dampens the empathy-like responses. |
| first_indexed | 2024-03-11T23:52:14Z |
| format | Article |
| id | doaj.art-86779ef1b90641c5a2e392486a5bfbf0 |
| institution | Directory Open Access Journal |
| issn | 2008-4633 2008-8469 |
| language | English |
| last_indexed | 2024-03-11T23:52:14Z |
| publishDate | 2019-12-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Addiction and Health |
| spelling | doaj.art-86779ef1b90641c5a2e392486a5bfbf02023-09-19T06:46:12ZengKerman University of Medical SciencesAddiction and Health2008-46332008-84692019-12-0111421622210.22122/ahj.v11i4.24389553Role of Opioid System in Empathy-like Behaviours in RatsMasoud Nazeri0Akram Nezhadi1Mohammad Shabani2Department of Neuroscience and Basic Sciences, School of Medicine, AJA University of Medical Sciences, Tehran, IranDepartment of Neuroscience and Basic Sciences, School of Medicine, AJA University of Medical Sciences, Tehran, IranDepartment of Neuroscience AND Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, IranBackground: Empathy is defined as the ability to simulate the mental states of others. Recent studies havedemonstrated empathy-like behaviors in other animals including rats and mice. The objective of the currentstudy was to evaluate the effect of acute administration of morphine and naloxone on cognition andnociception changes following observing conspecifics undergoing nociceptive stimulus.Methods: Adult male Wistar rats were used (n = 8 for each group). One cagemate received formalin injectioninto the hindpaw five times within a nine-day period and the other cagemate observed the pain while beingpretreated with saline, morphine, or naloxone [10 mg/kg, intraperitoneal (i.p.)]. Pain behaviors, anxiety-likebehaviour, locomotion, balance and muscle strength were evaluated in the observer animals.Findings: Observing a cagemate in pain increased anxiety-like behavior and reduced thermal pain threshold in theobserver animals. Administration of morphine reversed these effects and naloxone did not affect the responses.Conclusion: Results of the current study reveal an important role for opioid receptors (ORs) in empathy forpain, so that activation of this system dampens the empathy-like responses.https://ahj.kmu.ac.ir/article_89553_91d5c9317e4b93368822ffa10d21761b.pdfmorphineempathyratsanxiety |
| spellingShingle | Masoud Nazeri Akram Nezhadi Mohammad Shabani Role of Opioid System in Empathy-like Behaviours in Rats Addiction and Health morphine empathy rats anxiety |
| title | Role of Opioid System in Empathy-like Behaviours in Rats |
| title_full | Role of Opioid System in Empathy-like Behaviours in Rats |
| title_fullStr | Role of Opioid System in Empathy-like Behaviours in Rats |
| title_full_unstemmed | Role of Opioid System in Empathy-like Behaviours in Rats |
| title_short | Role of Opioid System in Empathy-like Behaviours in Rats |
| title_sort | role of opioid system in empathy like behaviours in rats |
| topic | morphine empathy rats anxiety |
| url | https://ahj.kmu.ac.ir/article_89553_91d5c9317e4b93368822ffa10d21761b.pdf |
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