Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival
Objectives: The objective of this study is to describe the imaging features of medulloblastoma (MB) and correlate the MR characteristics with the different histological subtype of MB with 2-year survival. Materials and Methods: This is a retrospective descriptive study. A total of 29 patients diagno...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-01-01
|
| Series: | Indian Journal of Radiology and Imaging |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/ijri.IJRI_209_19 |
| _version_ | 1819152476263153664 |
|---|---|
| author | Intan Zariza Hussain Faizah Mohd Zaki Shahizon Azura Mukari Suria Hayati Md Pauzi C-Khai Loh Hamidah Alias |
| author_facet | Intan Zariza Hussain Faizah Mohd Zaki Shahizon Azura Mukari Suria Hayati Md Pauzi C-Khai Loh Hamidah Alias |
| author_sort | Intan Zariza Hussain |
| collection | DOAJ |
| description | Objectives: The objective of this study is to describe the imaging features of medulloblastoma (MB) and correlate the MR characteristics with the different histological subtype of MB with 2-year survival. Materials and Methods: This is a retrospective descriptive study. A total of 29 patients diagnosed with MB from January 2005 to December 2015 were included in this study. The MRI brain and spine studies of these patients were retrieved and reviewed by a pediatric radiologist and a neuroradiologist independently, both blinded from the histological type of the MB. The HPE slides were also retrieved and reviewed by a pathologist. Results: 80% of desmoplastic MB showed the presence of intracranial leptomeningeal seeding and 57.1% of anaplastic MB showed the presence of necrosis. The presence of intracranial leptomeningeal seeding (P = 0.002) and necrosis (P = 0.019) was predictive of the histological subtypes. There is a significant correlation between the enhancement pattern and the 2-year outcome (P = 0.03) with 6 out of 8 patients whose tumors showed minimal enhancement having disease progression within 2 years. A significant correlation was also seen between the presence of necrosis with a poorer outcome (P = 0.03) and between the HPE subtype and 2-year outcome (P = 0.03) with anaplastic MB having the poorest prognosis. Conclusion: MR imaging features of intracranial leptomeningeal seeding and the presence of necrosis were correlated with a specific histologic subtype of MB. The enhancement pattern as well as necrosis correlated with 2-year poorer outcome of the disease. |
| first_indexed | 2024-12-22T14:49:54Z |
| format | Article |
| id | doaj.art-8678633a5b6d4decb433701eeff38105 |
| institution | Directory Open Access Journal |
| issn | 0971-3026 1998-3808 |
| language | English |
| last_indexed | 2024-12-22T14:49:54Z |
| publishDate | 2020-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Radiology and Imaging |
| spelling | doaj.art-8678633a5b6d4decb433701eeff381052022-12-21T18:22:21ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Radiology and Imaging0971-30261998-38082020-01-013001465110.4103/ijri.IJRI_209_19Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survivalIntan Zariza Hussain0Faizah Mohd Zaki1Shahizon Azura Mukari2Suria Hayati Md Pauzi3C-Khai Loh4Hamidah Alias5Departments of Radiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaDepartments of Radiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaDepartments of Radiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaDepartments of Pathology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaDepartments of Pediatrics, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaDepartments of Pediatrics, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, MalaysiaObjectives: The objective of this study is to describe the imaging features of medulloblastoma (MB) and correlate the MR characteristics with the different histological subtype of MB with 2-year survival. Materials and Methods: This is a retrospective descriptive study. A total of 29 patients diagnosed with MB from January 2005 to December 2015 were included in this study. The MRI brain and spine studies of these patients were retrieved and reviewed by a pediatric radiologist and a neuroradiologist independently, both blinded from the histological type of the MB. The HPE slides were also retrieved and reviewed by a pathologist. Results: 80% of desmoplastic MB showed the presence of intracranial leptomeningeal seeding and 57.1% of anaplastic MB showed the presence of necrosis. The presence of intracranial leptomeningeal seeding (P = 0.002) and necrosis (P = 0.019) was predictive of the histological subtypes. There is a significant correlation between the enhancement pattern and the 2-year outcome (P = 0.03) with 6 out of 8 patients whose tumors showed minimal enhancement having disease progression within 2 years. A significant correlation was also seen between the presence of necrosis with a poorer outcome (P = 0.03) and between the HPE subtype and 2-year outcome (P = 0.03) with anaplastic MB having the poorest prognosis. Conclusion: MR imaging features of intracranial leptomeningeal seeding and the presence of necrosis were correlated with a specific histologic subtype of MB. The enhancement pattern as well as necrosis correlated with 2-year poorer outcome of the disease.http://www.thieme-connect.de/DOI/DOI?10.4103/ijri.IJRI_209_19medulloblastomamrisurvival |
| spellingShingle | Intan Zariza Hussain Faizah Mohd Zaki Shahizon Azura Mukari Suria Hayati Md Pauzi C-Khai Loh Hamidah Alias Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival Indian Journal of Radiology and Imaging medulloblastoma mri survival |
| title | Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival |
| title_full | Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival |
| title_fullStr | Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival |
| title_full_unstemmed | Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival |
| title_short | Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival |
| title_sort | correlation between mri characteristics of medulloblastoma with histopathological subtypes and 2 year survival |
| topic | medulloblastoma mri survival |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/ijri.IJRI_209_19 |
| work_keys_str_mv | AT intanzarizahussain correlationbetweenmricharacteristicsofmedulloblastomawithhistopathologicalsubtypesand2yearsurvival AT faizahmohdzaki correlationbetweenmricharacteristicsofmedulloblastomawithhistopathologicalsubtypesand2yearsurvival AT shahizonazuramukari correlationbetweenmricharacteristicsofmedulloblastomawithhistopathologicalsubtypesand2yearsurvival AT suriahayatimdpauzi correlationbetweenmricharacteristicsofmedulloblastomawithhistopathologicalsubtypesand2yearsurvival AT ckhailoh correlationbetweenmricharacteristicsofmedulloblastomawithhistopathologicalsubtypesand2yearsurvival AT hamidahalias correlationbetweenmricharacteristicsofmedulloblastomawithhistopathologicalsubtypesand2yearsurvival |